Bartonella Interactions with Host Cells

  • Michael F. Minnick
  • Burt E. Anderson
Part of the Subcellular Biochemistry book series (SCBI, volume 33)


Bartonella species are versatile bacterial pathogens that can parasitize a variety of cells within the circulatory system of mammals. Following transmission by the bite of an arthropod, or through wounds inflicted by an infected mammal, bartonellae colonize the blood vasculature and produce an acute episode characterized by bacteremia and hemotrophy, low-grade fever and malaise, vascular lesions (hemangiomas, papules or peliosis) and lymphadenopathy. The course of disease can be life-threatening and frequently culminates in a carrier state within the host. Chronic Bartonella infections have been reported in humans, dogs, cats, rodents, and insect vectors such as lice and fleas. The wide variety of mammalian reservoirs and arthropod vectors (Table 1) suggests that infected animals and their ectoparasites will continue to be a perennial public health risk for humans.


Host Cell Human Umbilical Vein Endothelial Cell Inorganic Pyrophosphatase Bartonella Henselae Body Louse 
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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Michael F. Minnick
    • 1
  • Burt E. Anderson
    • 2
  1. 1.Division of Biological SciencesUniversity of MontanaMissoulaUSA
  2. 2.Department of Medical Microbiology and ImmunologyCollege of Medicine, University of South FloridaTampaUSA

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