Vaccines against Intracellular Pathogens

  • Raúl G. Barletta
  • Ruben O. Donis
  • Ofelia Chacón
  • Homayoun Shams
  • Jeffrey D. Cirillo
Part of the Subcellular Biochemistry book series (SCBI, volume 33)


Vaccination against intracellular pathogens presents unique problems that are specific to the growth environment used by these organisms. For all vaccines it is important to determine the best antigen(s) and inoculation method that will induce the proper strength and type of immune response as well as protect against subsequent challenge. With intracellular pathogens, however, the need for a cell-mediated immune response, limited direct access of the immune system to the infectious agent and potential for control of antigen processing and presentation in the host cell by the pathogen make vaccine design even more complex. The majority of the vaccines in use today, including those used for intracellular pathogens, were developed using traditional methods and the efficacies and inoculation methods determined empirically. The advent of molecular biology and the development of a better understanding of the mechanisms of immune protection should allow a more directed approach to vaccine design. Using Salmonella and mycobacteria as model intracellular pathogens, we review recent advances in our understanding of potential mechanisms of immune protection and methods of vaccine design and delivery. We propose directions for further study and strategies for the design and delivery of vaccines against intracellular pathogens based on current technology.


Human Immunodeficiency Virus Mycobacterium Tuberculosis Listeria Monocytogenes Vaccine Strain Typhoid Fever 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Raúl G. Barletta
    • 1
    • 2
  • Ruben O. Donis
    • 1
  • Ofelia Chacón
    • 1
    • 3
  • Homayoun Shams
    • 1
  • Jeffrey D. Cirillo
    • 1
  1. 1.Department of Veterinary and Biomedical SciencesUniversity of NebraskaLincolnUSA
  2. 2.Center of BiotechnologyUniversity of NebraskaLincolnUSA
  3. 3.Department of Veterinary PathobiologyTexas A&M UniversityCollege StationUSA

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