Interaction of Enteropathogenic Escherichia coli with Host Cells

  • Ilan Rosenshine
  • Stuart Knutton
  • Gad Frankel
Part of the Subcellular Biochemistry book series (SCBI, volume 33)


Most E. coli strains are non-pathogenic and constitute part of the normal gut flora. However, other E. coli strains may be pathogenic and can cause either bladder infection, meningitis, or diarrhea. At least five different classes of diarrheagenic E. coli have thus far been identified, including, enterotoxigenic E. coli (ETEC), enterohemorragic E. coli (EHEC), enteroaggregative E. coli (EAEC), enteroinvasive E. coli (EIEC), and enteropathogenic E. coli (EPEC). These E. coli strains, causing symptoms ranging from cholera-like to extreme colitis, possess distinct sets of virulence factors, including specific adhesins, invasins and/or toxins, which are responsible for the characteristic symptoms and diarrhea associated with each class.


Host Cell Secretion System Protein Translocation Host Cell Membrane Infected Epithelial Cell 
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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Ilan Rosenshine
    • 1
  • Stuart Knutton
    • 2
  • Gad Frankel
    • 3
  1. 1.Department of Molecular Genetics and BiotechnologyThe Hebrew University, Faculty of Medicine, The Hebrew UniversityJerusalemIsrael
  2. 2.Institute of Child HealthUniversity of BirminghamBirminghamUK
  3. 3.Department of Biochemistry, Imperial College of Science, Technology and MedicineUniversity of LondonLondonUK

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