Interaction of Rickettsiae with Eukaryotic Cells

Adhesion, Entry, Intracellular Growth, and Host Cell Responses
  • Marina E. Eremeeva
  • Gregory A. Dasch
  • David J. Silverman
Part of the Subcellular Biochemistry book series (SCBI, volume 33)


The genus Rickettsia includes obligate intracellular gram-negative bacteria which are associated with a variety of arthropod vectors. Based on antigenic, genetic, growth, and epidemiological characteristics, the genus is divided into the typhus group, which includes two human pathogens, Rickettsia prowazekii and R. typhi, and R. canada, which is known only from ticks, and the spotted fever group (SFG), which encompasses more than twenty distinct isolates (Raoult and Roux, 1997; Weiss and Moulder, 1984). The former scrub typhus group of rickettsiae was recently separated into a new genus, Orientia, which contains only a single species, O. tsutsugamushi (Tamura et al., 1995). Rickettsial species may cause diseases of different severity in humans which share the common symptoms of fever, rash, intoxication and vasculitis.


L929 Cell Human Endothelial Cell Hemolytic Activity Scrub Typhus PLA2 Activity 
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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Marina E. Eremeeva
    • 1
  • Gregory A. Dasch
    • 2
  • David J. Silverman
    • 1
  1. 1.School of MedicineUniversity of MarylandBaltimoreUSA
  2. 2.Naval Medical Research InstituteBethesdaUSA

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