Abstract
In recent years the use of the oral contraceptive preparations has provoked a considerable amount of discussion in the medical literature along with a vigorous reaction in the lay Press. Various side effects have been described and these have been in the main attributed to the oestrogen content of these preparations and, in particular, an increase in the incidence of venous and arterial thromboembolism in women taking oral contraceptives. (Inman, Vessey, Westerholm and Engelund, 1970; A Statement by the Committee on Safety of Drugs, 1970.) As a result of these findings the low oestrogen dosage is now being used as theincidence of serious thromboembolic phenomena is thereby significantly reduced. In addition to occlusive vascular lesions, there are numerous other complications, which in many instances require withdrawal of the drug, (Grant, 1968) and mood changes (Grant and Pryse-Davies, 1968) being two of the commoner troublesome features.
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References
Appenzeller, O., Davidson, K. and Marshall, J. (1963). Reflex vasomotor abnormalities in the hands of migrainous subjects. J. Neurol. Neurosurg. Psychiat. 26, 447.
Combined Oral Contraceptives. A Statement by the Committee on Safety of Drugs (1970). Brit. med. J. 2, 231.
Goldzieher, J. W., Becerra, C., Gual, C. et al. (1964). New oral contraceptive sequential estrogen and progestin. Amer. J. Obstet. Gynec. 90, 404.
Grant, E. C. G. (1965). Relation of arterioles in the endometrium to headache from oral contraceptives. Lancet i, 1143.
Grant, E. C. G. (1968). Relation between headaches from oral contraceptives and development of endometrial arterioles. Brit. med. J. 3, 402.
Grant, E. C. G. and Pryse-Davies, J. (1968). Effect of oral contraceptives on depressive mood changes and on endometrial monoamine oxidase and phosphatases. Brit. med. J. 3, 777.
Inman, W. H. W., Vessey, M. P., Westerholm, Barbro and Engelund, A. (1970). Thromboembolic disease and the steroidal content of oral contraceptives. A Report to the Committee on Safety of Drugs. Brit. med. J. 2, 203.
Lewis, A. and Hoghughi, M. (1969). An evaluation of depression as a side effect of oral contraceptives. Brit. J. Psychiat. 115, 697.
Mears, E. and Grant, E. C. G. (1962). “Anovlar” as an oral contraceptive. Brit. med. J. 2, 75.
Ostfeld, A. M., Reis, D. J., Goodell, H. and Wolff, H. G. (1955). Headache and hydration significance of two varieties of fluid accumulation in patients with vascular headache of migraine type. Arch. intern. Med. 96, 142.
Phillips, B. M. (1968). Oral contraceptive drugs and migraine. Brit. med. J. 2, 99.
Whitty, C. W. M., Hockaday, J. M. and Whitty, M. M. (1966). The effect of oral contraceptives on migraine. Lancet i, 856.
Winston, F. (1969). Oral contraceptives and depression. Lancet ii, 377.
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Phillips, B.M. (1971). Migraine and the Pill. In: Cumings, J.N. (eds) Background to Migraine. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4577-1_7
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DOI: https://doi.org/10.1007/978-1-4757-4577-1_7
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