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Kawasaki Disease

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Atlas of Vascular Disease

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Abstract

Kawasaki disease (KD), a leading cause of acquired heart disease in children in the United States, is a generalized vasculitis of unknown etiology. Most affected children are under the age of 2 years, and 85% of cases occur in children under 5 years of age. It is more common in males than in females (1.5:1). Within North America, the reported incidence of KD ranges from 6 to 11 per 100,000 children younger than 5 years of age [1], and while the incidence of KD is higher in children of Asian ancestry, children of all racial backgrounds are affected. KD was first reported by Tomisaku Kawasaki in 1967 in Japan, and was originally referred to as “mucocutaneous lymph node syndrome” [2]. More than 169,000 cases have been reported in Japan through 1998 [3], and KD has been recorded worldwide. Studies from Asia, Europe, and the Americas indicate that KD occurs in both endemic and community-wide epidemic forms [4].

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References

  1. Taubert KA, Shulman ST: Kawasaki disease. Am Fam Physician 1999, 59: 3093–3102.

    PubMed  CAS  Google Scholar 

  2. Kawasaki T: Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children (in Japanese). Jpn J Allergy 1967, 16: 178–222.

    CAS  Google Scholar 

  3. Japan Kawasaki Disease Research Committee: The results of the 16th nationwide survey of Kawasaki disease. Shonika Shinryo 2002, 65: 332–342.

    Google Scholar 

  4. Taubert KA: Epidemiology of Kawasaki disease in the United States and worldwide. Prog Pediatr Cardiol 1997, 6: 181–185.

    Article  Google Scholar 

  5. Diagnostic guidelines for Kawasaki disease. Circulation 2001, 103 (2): 335–336.

    Article  Google Scholar 

  6. Dajani AS, Taubert KA, Gerber MA, et al.: Diagnosis and therapy of Kawasaki disease in children. Circulation 1993, 87:1776–1780.

    Google Scholar 

  7. Dajani AS, Taubert KA, Takahashi M, et al.: Guidelines for longterm management of patients with Kawasaki disease. Circulation 1994, 89:918–922.

    Google Scholar 

  8. Davis RL, Waller PL, Mueller BA, et al.: Kawasaki syndrome in Washington State. Race-specific incidence rates and residential proximity to water. Arch Pediatr Adolesc Med 1995, 149(1):66–69.

    Google Scholar 

  9. Rauch AM: Kawasaki syndrome: critical review of U.S. epidemiology. In Kawasaki Disease. Edited by Shulman ST. New York: Alan R. Liss, Inc; 1987; 33–44.

    Google Scholar 

  10. Taubert KA, Rowley AH, Shulman ST: A ten-year (1984–1993) United States hospital survey of Kawasaki disease. In Kawasaki Disease. Edited by Kato H. New York: Elsiever Science BV; 1995: 34–38.

    Google Scholar 

  11. Shulman ST: A commentary on disease mechanism. In Proceedings of the Fourth International Symposium on Kawasaki Disease. Edited by Takahashi M, Taubert K. Dallas, TX: American Heart Association; 1993: 223–225.

    Google Scholar 

  12. Becker AE: Kawasaki disease: reflections on pathological observations. In Proceedings of the Fourth International Symposium on Kawasaki Disease. Edited by Takahashi M, Taubert K. Dallas, TX: American Heart Association; 1993: 226–230.

    Google Scholar 

  13. Arjunan K, Daniels SR, Meyer RA, et al.: Coronary artery caliber in normal children and patients with Kawasaki disease but without aneurysms: an echocardiographic and angiocardiographic study. J Am Coll Cardiol 1986, 8:1119–1124.

    Google Scholar 

  14. Lima M, Kaku S, Macedo A, et al.: Echocardiographic diagnosis and surgical treatment of giant coronary arterial aneurysms. In Proceedings of the Fourth International Symposium on Kawasaki Disease. Edited by Takahashi M, Taubert K. Dallas, TX: American Heart Association; 1993:404–407.

    Google Scholar 

  15. Takahashi M, Schieber RA, Wishner SH, et al.: Selective coronary arteriography in infants and children. Circulation 1983, 68:1021–1028.

    Google Scholar 

  16. Tornita S, Chung K, Mas M, et al.: Peripheral gangrene associated with Kawasaki disease. In Proceedings of the Fourth International Symposium on Kawasaki Disease. Edited by Takahashi M, Taubert K. Dallas, TX: American Heart Association; 1993:27–31.

    Google Scholar 

  17. Checchia PA, Pahl E, Shaddy RE, Shulman ST: Cardiac transplantation for Kawasaki disease. Pediatrics 1997, 100 (4): 695–699.

    Article  PubMed  CAS  Google Scholar 

  18. Kitamura S, Kameda Y, Seki T, et al.: Long-term outcome of myocardial revascularization in patients with Kawasaki coronary artery disease. A multicenter cooperative study. J Thorac Cardiovasc Surg 1994,107(3):663–673.

    Google Scholar 

  19. Newburger JW, Takahashi M, Burns JC, et al.: The treatment of Kawasaki syndrome with intravenous gamma-globulin. N Engl J Med 1986, 315:341–347.

    Google Scholar 

  20. Newburger JW, Takahashi M, Beiser AS, et al.: A single infusion of intravenous gamma-globulin compared to four daily doses in the treatment of acute Kawasaki syndrome. N Engl J Med 1991, 324:1633–1639.

    Google Scholar 

  21. Durongpisitkul K, Gururaj VJ, Park JM, Martin CF: The prevention of coronary artery aneurysm in Kawasaki disease: a meta-analysis on the efficacy of aspirin and immunoglobulin treatment. Pediatrics 1995, 96 (6): 1057–1061.

    PubMed  CAS  Google Scholar 

  22. Rowley AH, Duffy CE, Shulman ST: Prevention of giant coronary artery aneurysms in Kawasaki disease by intravenous gamma-globulin therapy. J Pediatr 1988, 113: 290–294.

    Article  PubMed  CAS  Google Scholar 

  23. Newburger JW: Treatment of Kawasaki disease: corticosteroids revisited. J Pediatr 1999, 135 (4): 411–413.

    Article  PubMed  CAS  Google Scholar 

  24. Mason WH, Takahashi M: Kawasaki syndrome. Clin Infect Dis 1999, 28 (2): 169–185.

    Article  PubMed  CAS  Google Scholar 

  25. Wallace CA, French JW, Kahn SJ, Sherry DD: Initial intravenous gammaglobulin treatment failure in Kawasaki disease. Pediatrics 2000, 105 (6): E78.

    Article  PubMed  CAS  Google Scholar 

  26. Newburger JW, Burns JC, Beiser AS, Loscalzo J: Altered lipid profile after Kawasaki syndrome. Circulation 1991, 84: 625–631.

    Article  PubMed  CAS  Google Scholar 

  27. Inoue O, Sugimura T, Kato H: Long-term lipid profiles in patients with Kawasaki disease. In Proceedings of the Fourth International Symposium on Kawasaki Disease. Edited by Takahashi M, Taubert K. Dallas, TX: American Heart Association; 1993: 305–309.

    Google Scholar 

  28. Salo EPI, Pesonen EJ, Viikari JSA: Serum cholesterol during and after Kawasaki disease. J Pediatr 1991, 119: 557–561.

    Article  PubMed  CAS  Google Scholar 

  29. American Academy of Pediatrics. National Cholesterol Education Program: Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. Pediatrics 1992, 89: 525–584.

    Google Scholar 

  30. Kato H, Ichinose E, Kawasaki T: Myocardial infarction in Kawasaki disease: clinical analyses in 195 cases. J Pediatr 1986, 108: 923–927.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Kathryn A. Taubert
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  2. Jane W. Newburger
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Editor information

Editors and Affiliations

  1. Department of Medicine, Harvard Medical School, Cardiovascular Division, Simon C. Fireman Scholar in Cardiovascular Medicine, Vascular Center, Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Mark A. Creager MD (Associate Professor, Director) (Associate Professor, Director)

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© 2003 Springer Science+Business Media New York

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Taubert, K.A., Newburger, J.W. (2003). Kawasaki Disease. In: Creager, M.A. (eds) Atlas of Vascular Disease. Current Medicine Group, London. https://doi.org/10.1007/978-1-4757-4564-1_9

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  • DOI: https://doi.org/10.1007/978-1-4757-4564-1_9

  • Publisher Name: Current Medicine Group, London

  • Print ISBN: 978-1-4757-4566-5

  • Online ISBN: 978-1-4757-4564-1

  • eBook Packages: Springer Book Archive

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