Positional Effects of the Phosphate Group on Thermal Polymerization of Isomeric Uridine Phosphates

  • A. M. Bryan
  • P. G. Olafsson


A calorimetric study of the abiogenic synthesis of biopolymers utilizing high temperature and relatively anhydrous conditions (the volcanic-areas rationale) has led to an even greater understanding of the process by which life may have originated on this planet. Accordingly the energetics associated with the thermal polymerization of the isomers of crystalline uridine monophosphates (2′-UMP, 3′-UMP and 5′-UMP) have been determined by differential scanning calorimetry. The thermal spectra are characteristic of a particular isomer and indicate the absence of a common intermediate in the condensation reactions of 2′-UMP and 3′-UMP. Enthalpimetric values indicate a preference for the following order in polymerization:-
$$ 5' - UMP > 3' - UMP > 2' - UMP $$
When equimolar mixtures of each of these isomers with uridine are subjected to thermal condensation, the lower melting base provides a fusion mixture in which polymerization can be initiated at a lower temperature, extends over a wider temperature range and can proceed to a greater degree than is possible in the absence or uridine.


Phosphate Group Exothermic Process Thermal Polymerization Thermal Spectrum Uridine Monophosphates 
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  1. 1.
    A. I. Oparin, “Proiskhozhdenie zhizni,” Izd. Moskovskii Rabochii, Moscow, 1924; “The Origin of Life,” The Macmillan Company, New York, New York 1938.Google Scholar
  2. 2.
    J. B. S. Haldane, “Rationalist Annual,” 1929: Science and Human Life,” Harper Bros., New York and London, pp 149 (1933).Google Scholar
  3. 3.
    J. Oro, N.Y. Acad. Sci. 108, 464 (1963).CrossRefGoogle Scholar
  4. 4.
    C. Ponnamperuma and P. Kirk, Nature 203, 400 (1964).CrossRefGoogle Scholar
  5. 5.
    C. Ponnampuruma and R. Mack, Science 148, 1221 (1965).CrossRefGoogle Scholar
  6. 6.
    A. Schwartz and S. W. Fox, Biochim Biophys. Acta, 87, 696 (1964); 134, 9 (1967).Google Scholar
  7. 7.
    J. Moravek, Tetrahedron Lett., 18, 1707 (1967).CrossRefGoogle Scholar
  8. 8.
    A. M. Bryan and P. G. Olafsson, J. Therm. Anal. 3, 421 (1971).CrossRefGoogle Scholar
  9. 9.
    T. V. Waehneldt and S. W. Fox, Biochem. Biophys. Acta, 134, 1 (1967).CrossRefGoogle Scholar
  10. 10.
    K. N. Fang, M. S. Kondo, P. S. Miller and P.O.P. Ts’o J. Am. Chem. Soc., 93, 6647 (1971).CrossRefGoogle Scholar
  11. 11.
    M. Sundaralingarn, Biopolymers 7, 821 (1961).CrossRefGoogle Scholar
  12. 12.
    S. Arnott, D. W. L. Hukins, Nature 224, 886 (1969).CrossRefGoogle Scholar
  13. 13.
    A. E. V. Haschemeyer and A. Rich, J. Mol. Biol., 27, 369 (1967).CrossRefGoogle Scholar
  14. 14.
    P. G. Olafsson, A. M. Bryan, G. C. Davis and T. S. Anderson, manuscript submitted for publication.Google Scholar
  15. 15.
    O. Pongs and P.O.P. Ts’o, J. Am. Chem. Soc., 93, 5241 (1971).CrossRefGoogle Scholar
  16. 16.
    E. Shefter and K. N. Trueblood, Acta Cryst., 18, 1067 (1965).CrossRefGoogle Scholar
  17. 17.
    J. Moravek, Tetrahedron Lett., 35, 4167 (1966)Google Scholar
  18. 18.
    A. Beck, R. Lohrmann and L. E. Orgel, Science 157, 952 (1967).CrossRefGoogle Scholar
  19. 19.
    M. W. Moon and H. G. Khorana, J. Am. Chem. Sco., 88, 1805 (1966).CrossRefGoogle Scholar
  20. 20.
    J. Moravek and J. Skoda, Coll. Czech. Chim. Commun. 32, 206 (1967).CrossRefGoogle Scholar
  21. 21.
    G. Schramm, H. G. Rotsh and W. Pollmann, Angew. Chemie Int. Ed. 1, 1 (1962).CrossRefGoogle Scholar
  22. 22.
    S. Greer and S. Zamenhof, J. Mol. Biol. 4, 123 (1962).CrossRefGoogle Scholar
  23. 23.
    M. M. Warshaw and C. R. Cantor, Biopolymers 9, 1079 (1970).CrossRefGoogle Scholar
  24. 24.
    P.O.P. Ts’o, S. A. Rappaport and F. J. Bollum, Biochemistry, 5, 4133 (1966).Google Scholar
  25. 25.
    J. Sulston, R. Lohrmann, L. E. Orgel, H. Schneider-Bernhoehr, B. J. Weimann and H. T. Miles, J. Mol. Biol., 40, 227 (1969).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • A. M. Bryan
    • 1
  • P. G. Olafsson
    • 1
  1. 1.Department of ChemistryState University of New York at AlbanyAlbanyUSA

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