Positional Effects of the Phosphate Group on Thermal Polymerization of Isomeric Uridine Phosphates
A calorimetric study of the abiogenic synthesis of biopolymers utilizing high temperature and relatively anhydrous conditions (the volcanic-areas rationale) has led to an even greater understanding of the process by which life may have originated on this planet. Accordingly the energetics associated with the thermal polymerization of the isomers of crystalline uridine monophosphates (2′-UMP, 3′-UMP and 5′-UMP) have been determined by differential scanning calorimetry. The thermal spectra are characteristic of a particular isomer and indicate the absence of a common intermediate in the condensation reactions of 2′-UMP and 3′-UMP. Enthalpimetric values indicate a preference for the following order in polymerization:-
When equimolar mixtures of each of these isomers with uridine are subjected to thermal condensation, the lower melting base provides a fusion mixture in which polymerization can be initiated at a lower temperature, extends over a wider temperature range and can proceed to a greater degree than is possible in the absence or uridine.
$$ 5' - UMP > 3' - UMP > 2' - UMP $$
KeywordsPhosphate Group Exothermic Process Thermal Polymerization Thermal Spectrum Uridine Monophosphates
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