The Detection of Impurities by Thermal Analysis

  • H. J. Ferrari
  • N. J. Passarello

Abstract

Thermal analysis is used in our laboratory to check material which is intended for use in clinical trials or toxicological studies. Invariably the quality of such samples will be of high purity, 98% or better. This immediately gives some idea of the test which confronts thermal analysis. Generally, we are dealing with samples containing a single impurity of <2% or several impurities of <2%. We feel that DTA has met this challenge with plenty to spare. It has earned its place as one of the techniques employed to evaluate the final purity of material intended for clinical and toxicological use.

Keywords

Thermal Analysis Melting Endotherm AMINOBENZOIC Acid Synthetic Mixture Purity Standard 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Brancone, L. M., Ferrari, H. J., Dept. 912, Vol. III, p. 246–303 (1965).Google Scholar
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    Brancone, L. M., Ferrari, H. J., Microchemical J., 10, No. 1–4, p. 370–392 (1966).CrossRefGoogle Scholar
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    Ferrari, H. J., in “Thermal Analysis” (R. F. Schwenker Jr. and Paul D. Garn) Academic Press, New York, Vol. 1, p. 41–64 (1969).CrossRefGoogle Scholar
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    Ferrari, H. J., Inoue, M., in “Differential Thermal Analysis” (R. C. MacKenzie) Academic Press, London, Vol. 2, p. 453–472 (1972).Google Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • H. J. Ferrari
    • 1
  • N. J. Passarello
    • 1
  1. 1.Lederle Laboratories DivisionAmerican Cyanamid Co.Pearl RiverUSA

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