Biologic Rhythms and Sympathetic Neural Control of Pineal Metabolism

  • Jorge A. Romero
Part of the Advances in experimental medicine and biology book series (AEMB, volume 108)


It is paradoxical that although we witness the manifestations of biologic aging daily in our lives and our surroundings, we still have such limited understanding of the basic mechanisms and causes of this universal process. Perhaps one of the greatest difficulties that face the science of gerontology is arriving at a concrete definition of aging that would then be the basis of and departure point for the investigation of the physiologic bases and etiology of this process. Even at an intuitive level, aging is seen to be a universal process or collection of processes which progressively and inexorably cause deleterious changes in the organism. Thus, after reaching maturity, the organism suffers a variety of involutional and degenerative changes which impair the organism’s adaptability to its external and internal environment, increase its susceptibility to the challenges of disease, and in the end result in the death of the organism.


Pineal Gland Suprachiasmatic Nucleus Diurnal Periodicity Dibutyryl cAMP Sympathetic Nerve Ending 
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Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Jorge A. Romero
    • 1
  1. 1.Department of NeurologyMassachusetts General HospitalBostonUSA

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