Biologic Rhythms and Sympathetic Neural Control of Pineal Metabolism

  • Jorge A. Romero
Part of the Advances in experimental medicine and biology book series (AEMB, volume 108)

Abstract

It is paradoxical that although we witness the manifestations of biologic aging daily in our lives and our surroundings, we still have such limited understanding of the basic mechanisms and causes of this universal process. Perhaps one of the greatest difficulties that face the science of gerontology is arriving at a concrete definition of aging that would then be the basis of and departure point for the investigation of the physiologic bases and etiology of this process. Even at an intuitive level, aging is seen to be a universal process or collection of processes which progressively and inexorably cause deleterious changes in the organism. Thus, after reaching maturity, the organism suffers a variety of involutional and degenerative changes which impair the organism’s adaptability to its external and internal environment, increase its susceptibility to the challenges of disease, and in the end result in the death of the organism.

Keywords

Pineal Gland Suprachiasmatic Nucleus Diurnal Periodicity Dibutyryl cAMP Sympathetic Nerve Ending 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Axelrod, J.A. The pineal gland: A neurochemical transducer. Science 184: 1341–1348, 1974.PubMedCrossRefGoogle Scholar
  2. Axelrod, J.A. and Weissbach, H. Purification and properties of hydroxyindole-0-methyltransferase. J. Biol. Chem. 236: 211–213, 1961.PubMedGoogle Scholar
  3. Alexrod, J.A. and Zatz, M. The beta-adrenergic receptor and the regulation of circadian rhythms in the pineal gland. In: Biochemical Actions of Hormones, G. Litwack, ed. Academic Press, New York, 1977.Google Scholar
  4. Axelrod, J.A., Wurtman, R.J. and Snyder, S.H. Control of hydroxy-indole-0-methyltransferase activity in the rat pineal gland by environmental lighting. J. Biol. Chem. 240: 949–954, 1965.PubMedGoogle Scholar
  5. Brownstein, M.J. and Axelrod, J.A. Pineal gland: 24-hour rhythm in norepinephrine turnover. Science 184: 163–165, 1974.PubMedCrossRefGoogle Scholar
  6. Brownstein, M.J., Saavedra, J.M. and Axelrod, J.A. Control of pineal N-acetylserotonin by a beta-adrenergic receptor. Mol. Pharm. 9: 605–611, 1973.Google Scholar
  7. Deguchi, T. Role of the beta-adrenergic receptor in the elevation of adenosine cyclic 3′-5′ monophosphate and induction of serotonin N-acetyltransferase in rat pineal glands. Mol. Pharm. 9: 184–190, 1973.Google Scholar
  8. Deguchi, T. and Axelrod, J.A. Control of circadian change of serotonin N-acetyltransferase activity in the pineal organ by the beta-adrenergic receptor. Proc. Nat. Acad. Sci. U.S.A. 69: 2547–2550, 1972.CrossRefGoogle Scholar
  9. Deguchi, T. and Axelrod, J.A. Superinduction of serotonin N-acetyltransferase and supersensitivity of adenyl cyclase to catecholamines in denervated pineal gland. Mol. Pharm. 9: 612–618, 1973.Google Scholar
  10. Hayflick, L. The cell biology of human aging. New Eng. J. Med. 295: 1302–1308, 1976.PubMedCrossRefGoogle Scholar
  11. Kappers, J.A. The development, topographical relations, and innervation of the epiphysis cerebri in the albino rat. Z. Zellforsch. Anat. 52: 153–215, 1960.Google Scholar
  12. Kebabian, J.W., Zatz, M., Romero, J.A. and Axelrod, J.A. Rapid changes in rat pineal beta-adrenergic receptors: Alterations in 1-(3H)-alprenolol binding and adenylate cyclase. Proc. Nat. Acad. Sci. U.S.A. 72: 3735–3739, 1975.CrossRefGoogle Scholar
  13. Klein, D.C. and Berg, G.R. Pineal gland: stimulation of melatonin production by norepinephrine involves cyclic AMP mediated stimulation of N-acetyltransferase. Adv. Biochem. Pharm. 3: 241–263, 1970.Google Scholar
  14. Klein, D.C. and Weller, J.L. Rapid light-induced decreases in pineal serotonin N-acetyltransferase activity. Science 177: 532–533, 1972.PubMedCrossRefGoogle Scholar
  15. Klein, D.C., Reiter, R.J. and Weller, J.L. Pineal N-acetyltransferase activity in blinded and anosmic male rats. Endocrinol. 89: 1020–1023, 1971a.CrossRefGoogle Scholar
  16. Klein, D.C., Weiler, J.L. and Moore, R.Y. Melatonin metabolism: Neural regulation of pineal serotonin: Acetylcoenzyme A N-acety1transferase activity. Proc. Nat. Acad. Sci. U.S.A. 68: 3107–3110, 1971b.CrossRefGoogle Scholar
  17. Moore, R.Y. and Klein, D.C. Visual pathway and the central neural control of a circadian rhythm in pineal N-acetyltransferase activity. Brain Res. 71: 17–33, 1974.PubMedCrossRefGoogle Scholar
  18. Ralph, C.L., Mull, D., Lynch, H.J. and Hedlund, L. A melatonin rhythm persists in rat pineals in darkness. Endocrinol. 89: 1361–1366, 1971.CrossRefGoogle Scholar
  19. Reiter, R.J. Comparative physiology: The pineal gland. Ann. Rev. Physiol. 35: 305–328, 1973.CrossRefGoogle Scholar
  20. Romero, J.A. and Axelrod, J.A. Pineal beta-adrenergic receptor: Diurnal variation in sensitivity. Science 184: 1091–1092, 1974.PubMedCrossRefGoogle Scholar
  21. Romero, J.A. and Axelrod, J.A. Regulation of sensitivity to beta-adrenergic stimulation in induction of pineal N-acetyltransferase. Proc. Nat. Acad. Sci. U.S.A. 72: 1661–1665, 1975.CrossRefGoogle Scholar
  22. Romero, J.A., Zatz, M. and Axelrod, J.A. Beta-adrenergic stimulation of pineal N-acetyltransferase: Adenosine 3′ 5′ monophosphate stimulates both RNA and protein synthesis. Proc. Nat. Acad. Sci. U.S.A. 72: 2107–2111, 1975.CrossRefGoogle Scholar
  23. Romero, J.A., Zatz, M., Kebabian, J.W. and Axelrod, J.A. Binding of 3H-alprenolol to beta-adrenergic receptor sites in rat pineal: Circadian cycles. Nature 258: 435–436, 1975.PubMedCrossRefGoogle Scholar
  24. Snyder, S.H., Zweig, M., Axelrod, J.A. and Fisher, J.E. Control of circadian rhythm in serotonin content of the rat pineal gland. Proc. Nat. Acad. Sci. U.S.A. 53: 301–305, 1965.CrossRefGoogle Scholar
  25. Snyder, S.H., Axelrod, J.A. and Zweig, M. Circadian rhythm in the serotonin content of the rat pineal gland: Regulating factors. J. Pharm. Exp. Ther. 158: 206–213, 1967.Google Scholar
  26. Taylor, A.N. and Wilson, R.W. Electrophysiological evidence for the action of light on the pineal gland in the rat. Experientia 26: 267–269, 1970.PubMedCrossRefGoogle Scholar
  27. Weiss, B. Effects of environmental lighting and chronic denervation on the activation of adenyl cyclase of rat pineal gland by norepinephrine and sodium fluoride. J. Pharm. Exp. Ther. 168: 146–152, 1969.Google Scholar
  28. Weissbach, H., Redfield, B.G. and Axelrod, J.A. Biosynthesis of melatonin: Enzymic conversion of serotonin to N-acetylserotonin. Biochim. Biophys. Acta. 43: 352–353, 1960.PubMedCrossRefGoogle Scholar
  29. Wurtman, R.J., Axelrod, J.A. and Kelly, D. The Pineal. Academic Press, New York, 1968.Google Scholar
  30. Zatz, M., Romero, J.A. and Axelrod, J.A. Diurnal variations on the requirement for RNA synthesis in the induction of pineal N-acetyltransferase. Biochem. Pharm. 25: 903–906, 1975.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1978

Authors and Affiliations

  • Jorge A. Romero
    • 1
  1. 1.Department of NeurologyMassachusetts General HospitalBostonUSA

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