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Intrauterine Fetal Growth Retardation

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Advances in Perinatal Medicine

Zusammenfassung

There has been an awareness throughout the history of civilization that runting may occur in various animal species, particularly those of a polytocous reproductive nature. However, it was only three decades ago that McBurney helped focus attention on the problem of human fetal growth retardation with his manuscript entitled The Undernourished Full—Term Infant. 1 He reported his observations of 69 term infants born with birth weights less than 2500 g, thus introducing the concept of fetal intrauterine growth retardation. However, little attention was paid to aberrations of fetal growth until 1963 when Gruenwald presented his concept of chronic placental insufficiency2 and Lubchenco defined a small—for—date infant [small—for—gestational—age (SGA) infant] as one whose birth weight is below the 10th percentile for a specific gestational age.3 Gruenwald’s and Lubchenco’s reports initiated a surge of interest in intrauterine fetal growth retardation (IUGR), and it quickly became evident that there was an attendant increased morbidity and mortality for the fetus, neonate, and surviving adult. The overall effect of these investigations was to stimulate research in the broader disciplines of fetal growth and development.

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References

  1. McBurney, R. D., 1947, The undernourished full term infant, West. J. Surg. Obstet. Gynecol. 5:363.

    Google Scholar 

  2. Gruenwald, P., 1963, Chronic fetal distress and placental insufficency, Biol. Neonate 5:215.

    CAS  Google Scholar 

  3. Lubchenco, L. O., Hansman, C, Dressier, M., et al., 1963, Intrauterine growth as estimated from liveborn birth—weight data at 24 to 42 weeks of gestation, Pediatrics 32:793.

    PubMed  CAS  Google Scholar 

  4. American Academy of Pediatrics, 1967, Committee on Fetus and Newborn. Nomenclature for duration of gestation, birthweight and intrauterine growth, Pediatrics 39:935.

    Google Scholar 

  5. World Health Organization, 1969, Prevention of perinatal morbidity and mortality, in: Public Health Papers, p. 42.

    Google Scholar 

  6. Battaglia, F. C, 1970, Intrauterine growth retardation, Am. J. Obstet. Gynecol. 106:1103.

    PubMed  CAS  Google Scholar 

  7. Yerushalmy, J., 1970, Relation of birth weight, gestational age, and the rate of intrauterine growth to perinatal mortality, Clin. Obstet. Gynecol. 13:107.

    PubMed  CAS  Google Scholar 

  8. Campbell, S., 1974, Fetal growth, Clin. Obstet. Gynecol. 1:41.

    CAS  Google Scholar 

  9. Varma, T. R., 1973, Prediction of delivery date by ultrasound cephalometry, J. Obstet. Gynaecol. Br. Commonw. 80:316.

    PubMed  CAS  Google Scholar 

  10. Dubowitz, L. M. S., Dubowitz, V., and Goldberg, C. G., 1970, Clinical assessment of gestational age of the newborn infant, J. Pediatr. 77:1.

    PubMed  CAS  Google Scholar 

  11. Gruenwald, P., 1966, Growth of the human fetus. l. Normal growth and its variation, Am. J. Obstet. Gynecol. 94:1112.

    PubMed  CAS  Google Scholar 

  12. Williams, R. L., Tashiro, M., Norris, F. D., et al., Fetal growth and perinatal mortality rates: Males vs. females, single vs. multiple births, personal communication.

    Google Scholar 

  13. Miller, H. C, and Hassanein, K., 1971, Diagnosis of impaired fetal growth in newborn infants, Pediatrics 48:511.

    PubMed  CAS  Google Scholar 

  14. Scott, K. E., and Usher, R., 1966, Fetal malnutrition: Its incidence, causes and effects, Am. J. Obstet. Gynecol. 94:951.

    PubMed  CAS  Google Scholar 

  15. Lugo, G., and Cassady, G., 1971, Intrauterine growth retardation. Clinicopathologic findings in 233 consecutive infants, Am. J. Obstet. Gynecol. 109:615.

    PubMed  CAS  Google Scholar 

  16. Galbraith, R. S., Karchmar, E. J., Piercy, W. N,, et al., 1979, The clinical prediction of intrauterine growth retardation, Am. J. Obstet. Gynecol. 133:281.

    PubMed  CAS  Google Scholar 

  17. van der Berg, B. J., and Yerusnalmy, J., 1966, The relationship of the rate of intrauterine growth retardation, Am. J. Obstet. Gynecol. 133:281.

    Google Scholar 

  18. Mann, L. I., Tejani, N. A., and Weiss, R. R., 1974, Antenatal diagnosis and management of the small—for—gestational age fetus, Am. J. Obstet. Gynecol. 120:995.

    PubMed  CAS  Google Scholar 

  19. Penrose, L. S., 1961, in: Recent Advances in Human Genetics (L. S. Penrose, ed.,), p. 56, Churchill, London.

    Google Scholar 

  20. Polani, P. E., 1974, Chromosomal and other genetic influences on birth weight variation, in: Size at Birth (K. Elliott and J. Knight, eds.), p. 127, Associated Scientific Publishers, Amsterdam.

    Google Scholar 

  21. Meredith, H. C, 1970, Body weights of viable human infants. A worldwide comparative treatise, Hum. Biol. 42:217.

    PubMed  CAS  Google Scholar 

  22. Karn, M. N., and Penrose, L. S., 1951, Birth weight and gestation time in relation to maternal age, parity and infants survival, Ann. Eugen. 16:147.

    PubMed  CAS  Google Scholar 

  23. Thomson, A. M., Billewicz, W. Z., and Hythen, F. E., 1968, The assessment of fetal growth,J. Obstet. Gynaecol. Br. Commonw. 75:906.

    Google Scholar 

  24. Walton, A., and Hammond, J., 1938, The maternal effects on growth and conformation in Shire horse—Shetland pony crosses, Proc. R. Soc. Biol. 125:311.

    Google Scholar 

  25. Ounsted, M., 1965, Maternal constraint of foetal growth in man, Dev. Med. Child. Neurol. 7:479.

    PubMed  CAS  Google Scholar 

  26. Ounsted, M., and Ounsted, C, 1966, Maternal regulation of intrauterine growth, Nature (London) 187:777.

    Google Scholar 

  27. Saugstad, L. F., 1972, Birth weights in children with phenylketonuria and in their siblings, Lancet 1:809.

    PubMed  CAS  Google Scholar 

  28. Chen, A. T. L., Chan, Y.-K., and Falek, A., 1972, The effects of chromosome abnormalities on birth weight in man. II. Autosomal defects, Hum. Hered. 22:209.

    PubMed  CAS  Google Scholar 

  29. Kucera, J., and Dolezalova, V., 1973, Prenatal development of malformed fetuses at 28–42 weeks of gestational age (anencephalus, hydrocephalus, Down’s syndrome, cleft lip and palate and hypospadius), Biol. Neonate 22:319.

    PubMed  CAS  Google Scholar 

  30. Pueschel, S. M., Rothman, K. J., and Ogilvy, J. D., 1976, Birth weight of children with Down’s syndrome, Am. J. Ment. Defic. 80:442.

    PubMed  CAS  Google Scholar 

  31. Anderson, N. G., 1976, A five—year study of small for dates infants for chromosomal abnormalities, Aust. Paediatr. J. 12:19.

    PubMed  CAS  Google Scholar 

  32. Chen, T. L., Sergovich, F. R., McKim, J. S., et al., 1970, Chromosome studies on full term, low birth weight mentally retarded patients,J. Pediatr. 76:393.

    CAS  Google Scholar 

  33. Barlow, P., 1973, The influence of inactive chromosomes on human development. Anomalous sex chromosomes complements and the phenotype, Hum. Genet. 17:105.

    CAS  Google Scholar 

  34. Chen, A. T. L., Chan, Y—K, and Falek, A., 1971, The effects chromosome abnormalities on birth weight in man. I. Sex chromosome disorders, Hum. Hered. 21:543.

    PubMed  CAS  Google Scholar 

  35. General discussion, 1974, in: Size at Birth (K. Elliott and J. Knight, eds.), p. 383, Associated Scientific Publishers, Amsterdam.

    Google Scholar 

  36. Klein, J. O., Remington, J. S., and Marcy, S. M., 1976, An introduction to infections of the fetus and newborn infant, in: Infectious Diseases of the Fetus and Newborn Infant (J. S. Remington and J. O. Klein, eds.), p. 1, Saunders, Philadelphia, Pa.

    Google Scholar 

  37. Naeye, R. L., and Blanc, W., 1965, Pathogenisis of congenital rubella,/. Am. Med. Assoc. 194:1277.

    CAS  Google Scholar 

  38. Naeye, R. L., 1967, Cytomegalovirus disease: The fetal disorder, Am. J. Clin. Pathol. 47:738.

    PubMed  CAS  Google Scholar 

  39. Whitley, R., and Alford, C. A., 1979, Chronic intrauterine and perinatal infections caused by rubella, cytomegaloviruses and herpes simplex virus, in: Antiviral Agents in Man (G. J. Galosso, ed.), Raven Press, New York.

    Google Scholar 

  40. Alford, C. A., Jr., 1976, Rubella, in: Infectious Diseases of the Fetus and Newborn Infant (J. S. Remington and J. O. Klein, eds.), p. 71, Saunders, Philadelphia, Pa.

    Google Scholar 

  41. Richards, M. R., Merrit, K. K., Samuels, M. H., et al., 1955, Congenital malformations of the cardiovascular system in a series of 6053 infants, Pediatrics 15:12.

    PubMed  CAS  Google Scholar 

  42. Naeye, R. L., 1965, Unsuspected organ abnormalities associated with congenital heart disease, Am. J. Pathol. 47:905.

    PubMed  CAS  Google Scholar 

  43. Froehlich, L. A., and Fujikura, T., 1966, Significance of a single umbilical artery, Am. J. Obstet. Gynecol. 94:274.

    PubMed  CAS  Google Scholar 

  44. Emmanouilides, G. C, Townsend, D. E., and Bauer, R. A., 1968, Effects of single umbilical artery ligation in the lamb fetus, Pediatrics 42:919.

    PubMed  CAS  Google Scholar 

  45. Shanklin, D. R., 1970, The influence of placental lesions and the newborn infants, Pediatr. Clin. North Am. 17:25.

    PubMed  CAS  Google Scholar 

  46. Benirschke, K., 1973, Multiple pregnancy, N. Engl. J. Med. 288:1276.

    PubMed  CAS  Google Scholar 

  47. Barcroft, J., and Kennedy, J. A., 1939, The distribution of blood between the fetus and placenta in sheep,J. Physiol. 95:173.

    PubMed  CAS  Google Scholar 

  48. Ibsen, H. L., 1928, Prenatal growth in guinea pigs with special reference to environmental factors affecting weight at birth,J. Exp. Zool. 51:151.

    Google Scholar 

  49. McKeown, T., and Record, R. G., 1952, Observations on foetal growth in multiple pregnancy in man,J. Endocrinol. 8:386.

    PubMed  CAS  Google Scholar 

  50. McKeown, T., and Record, R. G., 1953, The influence of placental size on foetal growth in man, with special reference to multiple gestation,/. Endocrinol. 9:418.

    CAS  Google Scholar 

  51. Naeye, R. L., Benirschke, K., Hagstrom, J. W. C, et al., 1966, Intrauterine growth of twins or estimated from liveborn—birth—weight data, Pediatrics 37:409.

    PubMed  CAS  Google Scholar 

  52. Naeye, R. L., 1965, Organ abnormalities in a human parabiotic syndrome, Am. J. Pathol. 46:892.

    Google Scholar 

  53. Brasel, J. A., and Winick, M., 1972, Maternal nutrition and prenatal growth. Experimental studies of effects of maternal undernutrition on fetal and placental growth, Arch. Dis. Child. 47:479.

    PubMed  CAS  Google Scholar 

  54. Dobbing, J., 1970, Undernutrition and the developing brain, Am. J. Dis. Child. 120:411.

    PubMed  CAS  Google Scholar 

  55. Winick, M., 1971, Cellular changes during placental and fetal growth, Am. J. Obstet. Gynecol. 109:166.

    PubMed  CAS  Google Scholar 

  56. Antonov, A. N., 1947, Children born during seige of Leningrad in 1942,J. Pediatr. 30:250.

    PubMed  CAS  Google Scholar 

  57. Stein, Z., and Susser, M., 1975, The Dutch famine, 1944–1945, and the reproductive process. I. Effects on six indices at birth, Pediatr. Res. 9:70.

    PubMed  CAS  Google Scholar 

  58. Love, E. J., and Kinch, R. A. H., 1965, Factors influencing the birth weight in normal pregnancy, Am. J. Obstet. Gynecol. 91:342.

    PubMed  CAS  Google Scholar 

  59. Niswander, K., and Jackson, E. C, 1974, Physical characteristics of the gravida and their association with birth weight and perinatal death, Am. J. Obstet. Gynecol. 119:306.

    PubMed  CAS  Google Scholar 

  60. Miller, H. C, and Merritt, T. A., 1979, Prepregnancy maternal habitus, in: Fetal Growth in Humans (H. C. Miller and T. A. Merritt, eds.), p. 77, Year Book Medical Publishers, Chicago, 111.

    Google Scholar 

  61. Crosby, W. M., Metcoff, J., Costiloe, J. P., et al., 1977, Fetal malnutrition: An appraisal of correlated factors, Am. J. Obstet. Gynecol. 128:22.

    PubMed  CAS  Google Scholar 

  62. Stein, Z., Susser, M., and Rush, D., 1978, Prenatal nutrition and birth weight: Experiments and quasi—experiments in the past decade,J. Reprod. Med. 21:287.

    PubMed  CAS  Google Scholar 

  63. Lichty, J. A., Ting, R. Y., Bruns, P. D., et al., 1957, Studies of babies born at high altitude, Am. J. Dis. Child. 93:666.

    CAS  Google Scholar 

  64. Kruger, H., and Arias-Stella, J., 1970, The placenta and the newborn infant at high altitudes, Am. J. Obstet. Gynecol. 106:586.

    PubMed  CAS  Google Scholar 

  65. Novy, M. J., Peterson, E. N., and Metcalfe, J., 1968, Respiratory characteristics of maternal and fetal blood in cyanotic congenital heart disease, Am. J. Obstet. Gynecol. 100:821.

    PubMed  CAS  Google Scholar 

  66. Faikpui, E. Z., and Moran, E. M., 1973, Pregnancy in the sickle hemoglobinopathies, J. Reprod. Med. 11:28.

    Google Scholar 

  67. Dawes, G. S., 1968, The placenta and foetal growth, in: Foetal and Neonatal Physiology (G. S. Dawes, ed.), p. 42, Year Book Medical Publishers, Chicago, Ill.

    Google Scholar 

  68. Aherne, W., 1966, A weight relationship between the human foetus and placenta, Biol. Neonate 10:113.

    CAS  Google Scholar 

  69. Molteni, R. A., Stys, S. J., and Battaglia, F. C, 1978, Relationship of fetal and placental weight in human beings: Fetal/placental weight ratios at various gestational ages and birth weight distributions,J. Reprod. Med. 21:327.

    PubMed  CAS  Google Scholar 

  70. Aherne, W., and Dunnill, M. S., 1966, Quantitative aspects of placental structure, J. Pathol. Bacteriol. 91:123.

    PubMed  CAS  Google Scholar 

  71. Baur, R., 1977, Morphometry of the placental exchange area, Adv. Anat. Embryol. Cell. Biol. 53:3.

    PubMed  CAS  Google Scholar 

  72. Aherne, W., 1975, Morphometry, in: The Placenta and Its Maternal Supply Line (P. Gruenwaod, ed.), p. 80, University Park Press, Baltimore, Md.

    Google Scholar 

  73. Fox, H., 1964, The villous cytotrophoblast as an index of placental ischemia, J. Obstet. Gynaecol. Br. Commonw. 71:885.

    PubMed  CAS  Google Scholar 

  74. Fox, H., 1967, The significance of placental infarction in perinatal morbidity and mortality, Biol. Neonate 11:87.

    CAS  Google Scholar 

  75. Fox, H., 1970, Effect of hypoxia on trophoblast in organ culture, Am. J. Obstet. Gynecol. 107:1058.

    PubMed  CAS  Google Scholar 

  76. Kulhanek, J. F., Meschia, G., Makowski, E. L., et al., 1974, Changes in DNA content and urea permeability of the sheep placenta, Am. J. Physiol 226:1257.

    Google Scholar 

  77. Stein, Z., and Susser, M., 1975, The Dutch famine, 1944–1945, and the reproductive process. II. Interrelations of caloric rations and six indices at birth, Pediatr. Res. 9:76.

    PubMed  CAS  Google Scholar 

  78. Wigglesworth, J. S., 1964, Experimental growth retardation in the foetal rat, J. Pathol. Bacteriol. 88:1.

    PubMed  CAS  Google Scholar 

  79. Duncan, S. L. B., 1969, The partition of uterine blood flow in the pregnant rabbit, J.Physiol 204:421.

    PubMed  CAS  Google Scholar 

  80. Hodari, A., 1967, Chronic uterine ischemia and reversible experimental “toxemia of pregnancy,” Am. J. Obstet. Gynecol. 97:597.

    PubMed  CAS  Google Scholar 

  81. Creasy, R. K., Barrett, C. T., de Swiet M., et al., 1972, Experimental intrauterine growth retardation in the sheep, Am. J. Obstet. Gynecol 112:566.

    PubMed  CAS  Google Scholar 

  82. Meschia, G., 1978, Substrate availability and fetal growth, in: Abnormal Fetal Growth: Biological Bases and Consequences (F. Naftolin, ed.), p. 221, Dahelem Konferenzen, Berlin.

    Google Scholar 

  83. Browne, J. C. M., and Veall, N., 1953, The maternal placental blood flow in normotensive and hypertensive women,. Obstet. Gynaecol. Br. Emp. 60:141.

    CAS  Google Scholar 

  84. Dixon, H. G., Browne, J. C. M., and Davey, D A., 1963, Choriodecidual and myometrial blood flow, Lancet 2:369.

    PubMed  CAS  Google Scholar 

  85. Caldeyro-Barcia, R., 1970, Fetal malnutrition: the role of maternal blood flow, Hosp. Pract. 1970:43.

    Google Scholar 

  86. Dixon, H. G., and Robertson, W. B., 1961, Vascular changes in the placental bed, Pathol. Microbiol. 23:262.

    Google Scholar 

  87. Borsens, I., Dixon, H. G., and Robertson, W. B., 1977, Fetal growth retardation and the arteries of the placental bed, Br. J. Obstet. Gynaecol. 84:656.

    Google Scholar 

  88. Robertson, W. B., Brosens, I., and Dixon, G., 1976, Maternal uterine vascular lesions in the hypertensive complications of pregnancy, in: Hypertension in Pregnancy (M. D. Lindheimer, A. I. Katz, and F. P. Zuspan, eds.), p. 115, Wiley, New York.

    Google Scholar 

  89. Burchell, R. C, Creed, F., Rasoulpour M., et al., 1978, Vascular anatomy of the human uterus and pregnancy wastage, Br. J. Obstet. Gynaecol 85:698.

    PubMed  CAS  Google Scholar 

  90. Theobald, G. W., 1953, Sympathetic nerves and eclampsia, Br. Med. J. 1:422.

    PubMed  CAS  Google Scholar 

  91. Beker, J. C, 1948, Aetiology of eclampsia,J. Obstet. Gynaecol. Br. Emp. 55:756.

    Google Scholar 

  92. Hibbard, B. M., and Jeffcoate, T. N. A., 1966, Abruptio placentae, Obstet. Gynecol 27:155.

    PubMed  CAS  Google Scholar 

  93. Varma, T. R., 1973, Fetal growth,J. Obstet. Gynaecol. Br. Commonw. 80:311.

    PubMed  CAS  Google Scholar 

  94. U. S. Department of Health, Education and Welfare, 1973, Smoking and pregnancy, in: The Health Consequences of Smoking, U.S. Dept. HEW, Washington, D.C.

    Google Scholar 

  95. Lowe, C. R., 1959, Effect of mother’s smoking habits on birth weight of these children, Br. Med. J. 2:673.

    PubMed  CAS  Google Scholar 

  96. Rantakallo, P., 1978, The effect of maternal smoking on birth weight and the subsequent health of the child, Early Hum. Dev. 2:371.

    Google Scholar 

  97. Cole, P. V., Hawkins, L. H., and Roberts, D., 1972, Smoking during pregnancy and its effects on the fetus,/. Obstet. Gynecol Br. Commonw. 79:782.

    CAS  Google Scholar 

  98. Longo, L. D., 1977, The biological effects of carbon monoxide on the pregnant woman, fetus and newborn infant, Am. J. Obstet. Gynecol. 129:69.

    PubMed  CAS  Google Scholar 

  99. Stone, M. L., Salerno, L. J., Green, M., et al., 1971, Narcotic addiction in pregnancy, Am. J. Obstet. Gynecol 109:716.

    PubMed  CAS  Google Scholar 

  100. Raye, J. R., and Dubin, J. W., and Blechner, J., 1975, Fetal growth restriction following maternal narcotic administration: Nutritional or drug effect, Pediatr. Res. 9:279.

    Google Scholar 

  101. Gurtner, G., and Burns, B., 1973, The role of cytochrome P450 of placenta in facilitated 0<Subscript>2</Subscript> diffusion, Drug Metab. Dispos. 1:374.

    PubMed  Google Scholar 

  102. Little, R. E., 1977, Moderate alcohol use during pregnancy and decreased infant birth weight, Am. J. Pub. Health 67:1154.

    CAS  Google Scholar 

  103. Thorburn, G. D., 1974, The role of the thyroid gland and kidneys in fetal growth, in: Size at Birth (K. Elliott and J. Knight, eds.), Associated Scientific Publishers, Amsterdam.

    Google Scholar 

  104. Anderson, H. J., 1962, Studies of hypothyroidism in children, Acta Paediatr. Scand, Suppl. 50:1.

    Google Scholar 

  105. Dussault, J. H., Row, V. V., Lickrish, G., et al., 1969. Studies of serum triiodothyronine concentration in maternal and cord blood transfer of triiodothyronine across the human placenta,J. Clin. Endocrinol. 29:595.

    CAS  Google Scholar 

  106. Holt, A. B., Cheek, D. B., and Kerr, G. R., 1973, Prenatal hypothyroidism and brain composition in a primate, Nature (London) 243:413.

    CAS  Google Scholar 

  107. Thomas, K., Gasparo, M. de, and Hoet, J. J., 1967, Insulin levels in the umbilical vein and in the umbilical artery of normal and gestation diabetic mothers, Diabetologia, 3:299.

    PubMed  CAS  Google Scholar 

  108. Cardell, B. S., 1953, Hypertrophy and hpyerplasia of the pancreatic islets in newborn infants,J. Pathol. Bacteriol. 66:335.

    PubMed  CAS  Google Scholar 

  109. Hill, D. E., Holt, A. B., Reba, R., et al., 1972, Alterations in the growth pattern of fetal rhesus monkeys following the in utero injection of streptozotocin, Pediatr. Res. 6:336.

    Google Scholar 

  110. Sherwood, W. G., Chance, G. W., and Hill, D. E., 1974, A new syndrome of pancreatic agenesis, Pediatr. Res. 8:360.

    Google Scholar 

  111. Liggins, G. C, 1974, The influence of the fetal hypothalmus and pituitary on growth, in: Size and Birth (K. Elliott and J. Knight, eds.), Associated Scientific Publishers, Amsterdam, p. 165.

    Google Scholar 

  112. Hall, K., and Sara, V., 1978, The significance of growth factors for fetal growth, in: Abnormal Fetal Growth: Biological Bases and Consequences (F. Naftolin, ed.), p. 121, Daheim Konferenzen, Berlin.

    Google Scholar 

  113. Svan, H., Hall, K., Ritzen, M., et al., 1977, Somatomedin A and B in serum from neonates, their mother and cord blood, Acta Endocrinol. 85:636.

    PubMed  CAS  Google Scholar 

  114. D’Ercole, A. J., Goushee, D. B., and Underwood, L. E., 1976, Somatomedin—C receptor ontogeny and levels in porcine fetal and human cord serum, J. Clin. Endocrinol. 43:1069.

    Google Scholar 

  115. PaceAsciak, C. R., 1978, Prostaglandin biosynthesis and catabolism in several organs of developing fetal and neonatal animals, in: Advances in Prostaglandin and Throm—boxane Research, Vol. 4 (F. Coceani and P. M. Olley, eds.), p. 45, Raven Press, New York.

    Google Scholar 

  116. Persaud, T. V. N., 1978, Prostaglandins in organogenesis, in: Advances in Prostaglandin and Thromboxane Research, Vol. 4 (F. Coceani and P. M. Olley, eds.), p. 139, Raven Press, New York.

    Google Scholar 

  117. MacDonald, P. C, Porter, J. C, Schwarz, B. E., et al., 1978, Initiation of parturition in the human female, Semin. Perinatol. 2:273.

    PubMed  CAS  Google Scholar 

  118. Rankin, J. H. G., and McLaughlin, M. K., 1979, The regulation of the placental blood flows, J. Dev. Physiol. 1:3.

    PubMed  CAS  Google Scholar 

  119. Cetrulo, C. L., and Feeman, R. F., 1977, Bioelectric evaluation in intrauterine growth retardation, Clin. Obstet. Gynecol. 20:979.

    PubMed  CAS  Google Scholar 

  120. Beazley, J. M., and Underhill, R. A., 1970, Fallacy of the fundal height, Br. J. Med. 4:404.

    CAS  Google Scholar 

  121. Loeffler, F. E., 1967, Clinical fetal weight prediction,J. Obstet. Gynaecol. Br. Commonw. 74:675.

    PubMed  CAS  Google Scholar 

  122. Billewicz, W. Z., and Thomson, A. M., 1973, Birth weights in consecutive pregnancies, Br. J. Obstet. Gynaecol. 80:491.

    CAS  Google Scholar 

  123. Naeye, R. L., 1965, Malnutrition: Probable causes of fetal growth retardation, Arch. Pathol. 79:284.

    PubMed  CAS  Google Scholar 

  124. Reynolds, J. W., and Mirkin, B. L., 1973, Urinary steroid levels in newborn infants with IUGR,J. Clin. Endocrinol. Metab. 36:576.

    PubMed  CAS  Google Scholar 

  125. Turnipseed, M. R., Bentley, K., and Reynolds, J. W., 1976, Serum dehydroepian—drosterone sulfate in premature infants and infants with intrauterine growth retardation,J. Clin. Endocrinol. Metab. 43:1219.

    PubMed  CAS  Google Scholar 

  126. Tulchinsky, D., Osathanondh, R., and Finn, A., 1976, Dehydroepiandrosterone sulfate loading test in the diagnosis of complicated pregnancies, N. Engl. J. Med. 294:517.

    PubMed  CAS  Google Scholar 

  127. Tanguy, G., Zorn, J. R., Sureau, C, et al., 1979, Exogenous DHA—S half—life: A good index of intra—uterine growth retardation, in: Serono Symposium on Placental Proteins and Hormones, Sienna, 1979.

    Google Scholar 

  128. Tulchinsky, D., 1977, Endocrine evaluation and diagnosis of IUGR, Clin. Obstet. Gynecol. 20:969.

    PubMed  CAS  Google Scholar 

  129. Klopper, A., 1968, The assessment of fetal placental function by estriol assay, Obstet. Gynecol. Surv. 23:813.

    Google Scholar 

  130. Yousem, H., Seitchik, J., and Solomon, D., 1966, Maternal estriol excretion and fetal dysmaturity, Obstet. Gynecol. 128:91.

    Google Scholar 

  131. Elliott, P. M., 1970, Urinary estriol excretion in retarded intrauterine fetal growth, Aust. N.Z.J. Obstet. Gynaecol. 10:18.

    PubMed  CAS  Google Scholar 

  132. Klopper, A., Jandial, V., and Wilson, G., 1975, Plasma steroid assay in the assessment of fetoplacental function, J. Steroid Biochem. 6:651.

    PubMed  CAS  Google Scholar 

  133. Spellacy, W. N., and Buhl, W. L., 1976, Human placental lactogen and intrauterine growth retardation, Obstet. Gynecol. 47:446.

    PubMed  CAS  Google Scholar 

  134. Spellacy, W. N., Usategui-Gomez, M., and Fernadez-Decastro, A., 1976, Plasma human placental lactogen, oxytocinase, and placental phosphatase in normal and toxemic pregnancies, Am. J. Obstet. Gynecol. 127:10.

    Google Scholar 

  135. Gohari, P., Hobbins, J. C., and Berkowitz, R. L., 1978, Use of HPL in the diagnosis of intrauterine growth retardation, Obstet. Gynecol. 52:127.

    PubMed  CAS  Google Scholar 

  136. Belanger, C., Shome, B., Friesen, H., et al., 1971, Studies of the secretion of monkey placental lactogen,J. Clin. Invest. 50:2660.

    PubMed  CAS  Google Scholar 

  137. Campbell, S., and Dewhurst, C. J., 1971, Diagnosis of the small—for—dates fetus by serial ultrasound cephalometry, Lancet 2:1002.

    PubMed  CAS  Google Scholar 

  138. Dewhurst, C. J., Beasley, J. M., and Campbell, S., 1972, Assessment of fetal maturity and dysmaturity, Am. J. Obstet. Gynecol. 113:141.

    PubMed  CAS  Google Scholar 

  139. Whetham, J. C. G., Muggah, H., and Davidson, S., 1976, Assessment of intrauterine growth retardation by ultrasound, Am. J. Obstet. Gynecol. 125:577.

    PubMed  CAS  Google Scholar 

  140. Sabbagha, R. E., 1978, Intrauterine growth retardation—Antenatal diagnosis by ultrasound, Obstet, Gynecol. 52:252.

    CAS  Google Scholar 

  141. Sabbagha, R. E., Barton, B. A., Barton, F. B., et al., 1976, Sonar biparietal diameter. II. Predictive of three fetal growth patterns, leading to a closer assessment of gestational age and neonatal weight, Am. J. Obstet. Gynecol 125:485.

    Google Scholar 

  142. Sabbagha, R. E., Hughey, M., and Depp, R., 1978, The assignment of growth— adjusted sonographic age (GASA)—A simplified method, Obstet. Gynecol. 51:383.

    PubMed  CAS  Google Scholar 

  143. Campbell, S., 1977, Ultrasound measurement of the fetal head to abdomen circum—ference ratio in assessment of growth retardation, Br. J. Obstet. Gynaecol. 84:165.

    PubMed  CAS  Google Scholar 

  144. Gohari, P., Berkowitz, R. L., and Hobbins, J. C, 1977, Prediction of intrauterine growth retardation by determination of total intrauterine volume, Am. J. Obstet. Gynecol. 127:255.

    PubMed  CAS  Google Scholar 

  145. Hobbins, J. C, and Berkowitz, R. L., 1977, Ultrasonography in the diagnosis of IUGR, Clin. Obstet. Gynecol. 20:957.

    PubMed  CAS  Google Scholar 

  146. Levine, S. C, Filly, R. A., and Creasy, R. K., 1979, Identification of fetal growth retardation by ultrasonographic estimation of total intrauterine volume, J. Clin. Ultrasound 7:21.

    PubMed  CAS  Google Scholar 

  147. Manning, F. A., and Platt, L. D., 1979, Qualitative Assessment of Amniotic Fluid Volume—A Rapid Screen for Detecting the Small for Gestational Age Fetus, Society for Gynecological Investigation, San Diego, p. 126.

    Google Scholar 

  148. Perry, C. P., Harris, R. E., DeLemos, R. A., et al., 1976, IUGR infants: Correlation of gestational with maternal factors, mode of delivery and perinatal survival, Obstet. Gynecol 48:182.

    PubMed  CAS  Google Scholar 

  149. Christie, G. B., and Cudmore, D. W., 1974, The oxytocin challenge test, Am. J. Obstet. Gyencol. 118:327.

    CAS  Google Scholar 

  150. Freeman, R. K., Goebbelsmann, U., Nochimson, D., et al., 1976, Evaluation of the significance of a positive oxytocin challenge test, Obstet. Gynecol. 47:8.

    PubMed  CAS  Google Scholar 

  151. Trierweiler, M. W., Freeman, R. K., and James, J., 1976, Baseline fetal heart rate characteristics as an indicator of fetal status during the antepartum period, Am. J. Obstet. Gynecol 125:618.

    PubMed  CAS  Google Scholar 

  152. Rochard, F., Schifrin, B. S., Goupil, F., et al., 1976, Nonstressed fetal heart rate monitoring in the antepartum period, Am. J. Obstet. Gynecol 126:699.

    PubMed  CAS  Google Scholar 

  153. Evertson, L. R., Gauthier, R. J., Schifrin, B. S., et al., 1979, Antepartum fetal heart rate testing. I. Evolution of the nonstress test, Am. J. Obstet. Gynecol. 133:29.

    PubMed  CAS  Google Scholar 

  154. Boddy, K., and Dawes, G. S., 1975, Fetal breathing, Br. Med. Bull. 31:3.

    PubMed  CAS  Google Scholar 

  155. Manning, F. A., and Platt, L. D., 1979, Fetal breathing movements and the abnormal contraction stress, Am. J. Obstet. Gynecol. 133:590.

    PubMed  CAS  Google Scholar 

  156. Manning, F. A., and Platt, L. D., 1979, Antepartum Fetal Assessment—A Biophysical Profile, Society for Gynecologic Investigation, San Diego, p. 171.

    Google Scholar 

  157. Golbus, M. S., Hall, B. D., and Creasy, R. K., 1976, Prenatal diagnosis of congenital anomalies in an intrauterine growth retarded fetus, Hum. Genet. 32:349.

    PubMed  CAS  Google Scholar 

  158. Roberts, J. M., 1979, When the hypertensive patient becomes pregnant, Contemp. Obstet. Gynecol 13:47.

    Google Scholar 

  159. Page, I. B., and Sidd, J. J., 1972, Medical management of primary hypertension, N. Engl. J. Med. 287:1018.

    PubMed  CAS  Google Scholar 

  160. Metcalfe, J., and Ueland, K., 1984, Maternal cardiovascular adjustments to pregnancy, Prog. Cardiovasc. Dis. 16:363.

    Google Scholar 

  161. Suonid, S., Simpanen, A-L., Olkkonen, H., et al., 1976, Effect of the left lateral recumbent position compared with the supine and upright positions on placental blood flow in normal late pregnancy, Ann. Clin. Res. 8:22.

    Google Scholar 

  162. Beischer, N. A., and O’Sullivan, E. F., 1972, The effect of rest and intravenous infusion of hypertonic dextrose on subnormal estriol excretion in pregnancy, Am. J. Obstet. Gynecol. 113:771.

    PubMed  CAS  Google Scholar 

  163. Ehrenkranz, R. A., Walker, A. J., Bakes, G. K., et al., 1976, Effect of ritodrine infusion on uterine and umbilical blood flow in pregnant sheep, Am. J. Obstet. Gynecol 126:343.

    PubMed  CAS  Google Scholar 

  164. Siimes, A. S. I., and Creasy, R. K., 1979, Cardiac and uterine hemodynamic responses to ritodrine hydrochloride administration in pregnant sheep, Am. J. Obstet. Gynecol. 133:20.

    PubMed  CAS  Google Scholar 

  165. Wallenburg, H. C. S., Mazer, J., and Hutchinson, D. L., 1973, Effects of a beta—adrenergic agent, (metaproterenol) on uteroplacental circulation: An angiographic study in the pregnant rhesus monkey, Am. J. Obstet. Gynecol 117:1067.

    PubMed  CAS  Google Scholar 

  166. Janisch, H., Leodolter, S., and Reinold, R., 1974, Uteroplazentaee Durchblutungs—verbesserung bei EPH—Gestose durch Langzeit—Therapie mit beta—Sympathikomimetika, A. Geburtsh. Perinatol. 178:202.

    CAS  Google Scholar 

  167. Brettes, J. P., Renaud, R., and Gandar, R., 1976, A double—blind investigation into the effects of ritodrine on uterine blood flow during the third trimester of pregnancy, Am. J. Obstet. Gynecol. 124:164.

    PubMed  CAS  Google Scholar 

  168. Guikovaty, J. P., Vors, J., Vergnes, R., et al., 1975, Hemodynamique uteroplacetaire au cours des grossesses normales et pathologiques: Ses modifications sous l’influence d’un beta—sympathico—mimetique: Le salbutamol,J. Gynecol. Obstet. Biol. Reprod. (Paris) 4:671.

    CAS  Google Scholar 

  169. Sivasamboo, R., 1972, Premature labor, in: Proceedings of of the International Symposium on the Treatment of Foetal Risks (K. Baumgarten and A. Wesslius-De-Casparis, eds.), p. 16, University of Vienna, Vienna.

    Google Scholar 

  170. Seidl, A., Baumgarten, K., Eisner, R., et al., 1972, Auswirkun der Ritodrine—Behandlung auf das Kindesgewicht, in: Proceedings of the International Symposium on the Treatment of Foetal Risks (K. Baumgarten and A. Wesslius-De-Casparis, eds.), p. 61, University of Vienna, Vienna.

    Google Scholar 

  171. Renaud, R., Vincendon, G., Boog, G., et al., 1972, Injections intra—amoniotiques d’acides amines dans les cas de malnutrition foetale,J. Gynecol. Obstet. Biol. Reprod. (Paris) 1:231.

    CAS  Google Scholar 

  172. Butler, N. R., and Alberman, E. D., 1969, in: Perinatal Problems: The Second Report of the British Perinatal Mortality Survey, Churchill, Livingstone, Edinburgh.

    Google Scholar 

  173. Low, J. A., Boston, R. W., and Pancham, S. R., 1972, Fetal asphyxia during the antepatrum period in intrauterine growth retarded infants, Am. J. Obstet. Gynecol. 113:351.

    PubMed  CAS  Google Scholar 

  174. Gregory, G. A., Gooding, C. A., Phibbs, R. H., et al., 1974, Meconium aspiration in infants, a prospective study,J. Pediatr. 85:848.

    PubMed  CAS  Google Scholar 

  175. Carson, B. S., Losey, R. W., Bowes, W. A., Jr., et al., 1976, Combined obstetrics and pediatrics approach to prevent meconium aspiration syndrome, Am. J. Obstet. Gynecol. 126:712.

    PubMed  CAS  Google Scholar 

  176. Oh, W., 1977, Considerations in neonates with intrauterine growth retardation, Clin. Obstet. Gynecol. 20:991.

    PubMed  CAS  Google Scholar 

  177. Siegel, S. R., and Oh, W., 1976, Renal function as a marker of human fetal maturation, Acta Pediatr. Scand. 65:481.

    CAS  Google Scholar 

  178. Lucas, A., Christofides, N. D., Adrian, T. E., et al., 1979, Fetal distress, meconium, motilin, Lancet 1:718.

    PubMed  CAS  Google Scholar 

  179. Lubchenco, L. O., and Bard, H., 1971, Incidence of hypoglycemia in newborn infants classified by birth weight and gestational age, Pediatrics 47:831.

    PubMed  CAS  Google Scholar 

  180. Koivisto, M., Blaco-Sequeiros, M., and Krause, U., 1972, Neonatal symptomatic and asymptomatic hypoglycemia—A follow—up study of 151 children, Dev. Med. Child Neurol. 14:603.

    PubMed  CAS  Google Scholar 

  181. Tsang, R. C, and Oh, W., 1970, Neonatal hypocalcemia in low birth weight infants, Pediatrics 45:773.

    PubMed  CAS  Google Scholar 

  182. Humbert, J. R., Abelson, H., Hathaway, W. E., et al., 1969, Polycythemia in SGA infants,J. Pediatr. 78:812.

    Google Scholar 

  183. Finne, P. H., 1966, Erythropietin levels in cord blood as an indicator of intrauterine hypoxia, Acta Pediatr. Scand. 55:478.

    CAS  Google Scholar 

  184. Oh, W., Omori, A., Emmanouilides, G. C, et al., 1975, Placenta to lamb fetus transfusions in utero during acute hypoxia, Am. J. Obstet. Gynecol. 122:316.

    Google Scholar 

  185. Stewart, A. L., Turcan, D. M., Rawlings, G., et al., 1977, Prognosis for infants weighting 100 g or less at birth, Arch. Dis. Child. 52:97.

    PubMed  CAS  Google Scholar 

  186. Babson, S. G., 1970, Growth of low—birth—weights infants,J. Pediatr. 77:11.

    PubMed  CAS  Google Scholar 

  187. Fitzhardinge, P. M., and Steven, E. M., 1972, The small—for—date infant. I. Later growth patterns, Pediatrics 49:671.

    PubMed  CAS  Google Scholar 

  188. Stuart, H. C, and Reed, R. B., 1959, Longitudinal studies of child health and development, Pediatrics 24(Suppl):875.

    PubMed  CAS  Google Scholar 

  189. Low, J. A., Galbraith, R. S., Muir, D., et al., 1978, Intrauterine growth retardation: A preliminary report of long—term morbidity, Am. J. Obstet. Gynecol. 130:534.

    PubMed  CAS  Google Scholar 

  190. Babson, S. G., Kangas, J., Young, N., et al., 1964, Growth and development of twins of dissimilar size at birth, Pediatrics 33:327.

    PubMed  CAS  Google Scholar 

  191. Babson, S. G., and Phillips, D. S., 1973, Growth and development of twins dissimilar in size at birth, N. Engl. J. Med. 289:937.

    PubMed  CAS  Google Scholar 

  192. Gatson, A., Crowther, D., Harvin, D., et al., 1972, Development of infants with intrauterine growth retardation, Clin. Res. 20:280.

    Google Scholar 

  193. Holmes, G. E., Miller, H. C., Hassnein, K., et al., 1977, Postnatal somatic growth in infants with atypical fetal growth patterns, Am. J. Dis. Child. 131:1078.

    Google Scholar 

  194. Ounsted, M., and Sleigh, G., 1975, The infant’s self—regulation of food intake and weight gain, Lancet 1:1393.

    PubMed  CAS  Google Scholar 

  195. Fancourt, R., Campbell, S., Harvey, D., et al., 1976, Follow—up study of small—for—dates babies, Br. Med. J. 1:1435.

    PubMed  CAS  Google Scholar 

  196. Drillien, C. M., 1970, The small—for—date infant: Etiology and prognosis, Pediatr. Clin. North Am. 17:9.

    PubMed  CAS  Google Scholar 

  197. Fizhardinge, P. M., and Steven, E. M., 1972, The small—for—date infant. II. Neuro—logical and intellectual sequelae, Pediatrics 50:50.

    Google Scholar 

  198. Beargie, R. A., James, V. L., and Green, J. W., 1970, Growth and development of small—for—date newborns, Pediatr. Clin. North Am. 17:159.

    PubMed  CAS  Google Scholar 

  199. Babson, S. G., and Kangas, J., 1969, Preschool intelligence of undersized term infants, Am. J. Dis. Child. 117:553.

    PubMed  CAS  Google Scholar 

  200. Creasy, R. K., de Swiet, M., Kahanpaa, K. V., et al., 1972, Pathophysiological changes in the foetal lamb with growth retardation, in: Foetal and Neonatal Physiology, Proceedings of the Sir Joseph Barcroft Centenary Symposium (K. S. Comline, K. W. Cross, G. S. Dawes, and P. W. Nathanielsz, eds.), p. 398, Cambridge University Press, Cambridge.

    Google Scholar 

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© 1981 Aubrey Milunsky, Emanuel A. Friedman, and Louis Gluck

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Creasy, R.K., Resnik, R. (1981). Intrauterine Fetal Growth Retardation. In: Milunsky, A., Friedman, E.A., Gluck, L. (eds) Advances in Perinatal Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4451-4_4

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