Abstract
Polyunsaturated fatty acids with 20-carbon atoms, derived from the linoleic and alpha-linolenic dietary essential fatty acids (EFA), are the natural substrates in tissues for the formation of metabolic products endowed with potent biological activities. Theseroducts include prostaglandins (PG) and other related compounds, such as thromboxanes (Tx), prostacyclin (PGI2), and the newly discovered leukotrienes (Hammarström et al.,1979). Dietary factors—fatty acids and components affecting the utilization and metabolism of dietary EFA—are known to modulate the accumulation of long-chain polyunsaturated fatty acids (PUFA). Also, information is available on the effects of dietary manipulation on PG production in the body or in selected organs. Finally, the administration of diets with varying levels of linoleic acid has been shown, in animals and humans, to modify several physiological parameters, especially in the cardiovascular system; these effects have been correlated, at experimental or theoretical levels, with changes of PG production.
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References
Aaes-Jorgensen, E., and Holman, R. T., 1958, Essential fatty acid deficiency. 1. Content of polyenoic acids in testes and heart as an indicator of EFA status, J. Nutr. 65: 633.
Agradi, E., Tremoli, E., Colombo, C., and Galli, C., 1978, Influence of short term dietary supplementation of different lipids on aggregation and arachidonic acid metabolism in rabbit platelets, Prostaglandins 16: 973.
Alfin-Slater, R. B., Morris, R. S., Hansen, H., and Proctor, J. F., 1965, Effects of non-essential fatty acids on essential fatty acid deficiency, J. Nutr. 87: 168.
Ansell, G. B., Dawson, R. M. C., and Hawthorne, J. N., 1975, Table 20, in Form and Function of Phospholipids ( G. B. Ansell, R. M. C. Dawson, and J. N. Hawthorne, eds.), p. 468, Elsevier, New York.
Bergstrom, S., Danielsson, H., Klenberg, D., and Samuelsson, B., 1964, The enzymatic conversion of essential fatty acids into prostaglandins, J. Biol. Chem. 239: 4006.
Bieri, J. G., Mason, K. E., and Prival, E. L., 1968, Testis requirement for vitamin A in the rat and the effect of essential fatty acids, Int. Z. Vitaminforsch. 38: 312.
Bills, T. K., Smith, J. B., and Silver, M. J., 1976, Metabolism of (“C) arachidonme>ic acid by human platelets, Biochim. Biophys. Acta 424: 303.
Bizzi, A., Veneroni, E., Garattini, S., Puglisi, L., and Paoletti, R., 1967, Hypersensitivity to lipid mobilizing agents in essential fatty acid deficient rats, Eur. J. Pharm. 2: 48.
Blackwell, G. J., Duncombe, W. G., Flower, R. J., Parsons, M. F., and Vane, J. R., 1977, The distribution and metabolism of arachidonic acid in rabbit platelets during aggregation and its modification by drugs, Br. J. Pharmacol. 59: 353.
Boehme, M. A.,and Branen, A. L., 1977, Effects of food antioxidants on prostaglandin biosynthesis, J. Food Sci. 42: 1243.
Bonta, I. L., Chrispijn, H., Noordhoek, J., and Vincent, J. E., 1974, Reduction of prostaglandin-phase in hind-paw inflammation and partial failure of indomethacin to exert antiinflammatory effect in rats on essential fatty acid deficient diet, Prostaglandins 5: 495.
Bonta, I. L., Bult, H., v. d. Ven, L. L. M., and Noordhoek, J., 1976, Modification of adjuvant inflammation in rats deficient in EFA, Agents Actions 6: 636.
Bonta, I. L., Parnham, M. J., and Adolfs, M. J. P., 1977, Reduced exudation and increased tissue proliferation during chronic inflammation in rats deprived of endogenous prostaglandin precursors, Prostaglandins 14: 295.
Bryant, R. W., and Bailey, J. M., 1980, Isolation of glucose-sensitive platelet lipoxygenase products from arachidonic acid, in Advances in Prostaglandin and Thromboxane Research, Vol. 6 ( B. Samuelsson, P. Ramwell, and R. Paoletti, eds.), p. 95, Raven Press, New York.
Bult, H., and Bonta, I. L., 1976, Rat platelets aggregate in the absence of endogenous precursors of prostaglandin endoperoxide, Nature 264: 449.
Carney, J. A., Lewis, A., Walker, B. L., and Slinger, S. J., 1972, Effect of dietary rapeseed oil on the adrenocorticotrophin-induced production of prostaglandins in the rat adrenal, Biochim. Biophys. Acta 280: 211.
Casai, J. J., and Holman, R. T., 1965, The effect of kind of dietary carbohydrate upon composition of liver fatty acids in the rat. J. Amer. Oil. Chem. Soc. 42: 1134.
Cash, R., and Berger, C. K., 1969, Acrodermatitis enteropathica: Defective metabolism of unsaturated fatty acids, J. Pediatr. 74: 717.
Caster, W. O., Andrews, J. W., Jr., Mohrhauer, H., and Holman, R. T., 1976, Effect of essential and non essential fatty acids in complex mixture on fatty acid composition of liver lipids, J. Nutr. 106:1809.
Chignard, M., and Vargaftig, B. B., 1977, Synthesis of thromboxane A2 by nonaggregating dog platelets challenged with arachidonic acid or with prostaglandin H2, Prostaglandins 14: 222.
Christ, E. J., and Nugteren, D. H., 1970, The biosynthesis and possible function of prostaglandins in adipose tissue, Biochim. Biophys. Acta 218: 296.
Christiansen, K., Marcel, Y., Gan, M. V., Mohrhauer, H., and Holman, R. T., 1968, Chain elongation of a-and y-linolenic acids and the effect of other fatty acids on their conversion in vitro, J. Biol. Chem. 243: 2969.
Comberg, H. U., Heyden, S., Hames, C. G., Vergroesen, A. J., and Fleischman, A. I., 1978, Hypotensive effect of dietary prostaglandin precursor in hypertensive man, Prostaglandins 15: 193.
Crawford, M. A., Denton, J. P., Hassam, A. G., Lynn, J., Marples, P., Stevens, P., and Willis, A. L., 1978, Levels of prostaglandins and their precursors in EFA-deficient rabbits—a new concept of prostaglandin biosynthesis, Br. J. Pharmacol. 63: 363.
Danon, A., Chang, L. C. T., Sweetman, B. J., Nies, A. S., and Oates, J. A., 1975a, Synthesis of prostaglandins by the rat renal papilla in vitro. Mechanism of stimulation by angiotensin II, Biochim. Biophys. Acta 388: 71.
Danon, A., Heimberg, M., and Oates, J. A., 1975b, Enrichment of rat tissue lipids with fatty acids that are prostaglandin precursors, Biochim. Biophys. Acta 388: 318.
Dawes, G. S., 1978, Conclusions, in Prostaglandin and Perinatal Medicine (F. Coceani and P. M. 011ey, eds.), p. 387, Raven Press, New York.
deDeckere, E. A. M., and ten Hoor, F., 1979, Effects of dietary fats on the coronary flow rate and the left ventricular function of the isolated rat heart, Nutr. Metab. 23: 88.
Denko, C. W., 1974, Effect of prostaglandins in urate crystal inflammation, Pharmacology 12:331. DePury, G. G., and Collins, F. 0., 1965, A raised level of free fatty acids in serum of rats deficient in essential fatty acids as a contributing cause of their fatty liver, Biochim. Biophys. Acta 106: 213.
Dupont, J., Mathias, M. M., and Connally, P. T., 1978, Prostaglandin synthesis as a function of dietary linoleate concentration, Fed. Proc. 37: 445.
Dussault, P. E., and Lepage, M., 1975, Effects of pyridoxine deficiency on the composition of plasma and liver fatty acids in rats fed low and high fat diets, J. Nutr. 105: 1371.
Dyerberg, J., Bang, H. 0., Stoffersen, E., Moncada, S., Vane, J. R., 1978, Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 2: 117.
Ehrström, M. C., 1951, Medical studies in north Greenland, 1948-49, Part 6 (Blood pressure, hypertension and arteriosclerosis in relation to food and mode of living), Acta Med. Scand. 140: 416.
Fain, J. N., 1973, Biochemical aspects of drug and hormone action on adipose tissue, Pharmacol. Rev. 25: 67.
Flower, R. J., Cheung, H. S., and Cushman, D. W., 1973, Quantitative determination of prostaglandins and malondialdehyde formed by the arachidonate oxygenase (prostaglandin synthetase) system of bovine seminal vesicle, Prostaglandins 4: 325.
Förster, W., and Triebe, G., 1975, Influence of linoleic acid rich or linoleic acid low diet on DOCA hypertension and the prostaglandin synthetase and dehydrogenase activity in the rat kidney, Artery 1: 349.
Friedman, Z., Lamberth, E. L., Stahlman, M. T., and Oates, J. A., 1977, Platelet dysfunction in the neonate with essential fatty acid deficiency, J. Pediatr. 90: 439.
Friedman, Z., Seyberth, H. W., Lambert, E. L., and Oates, J. A., 1978, Decreased prostaglandin E turnover in infants with essential fatty acid deficiency, Pediatr. Res. 12: 74.
Galli, C., and Spagnuolo, C., 1974, Essential fatty acids in maternal diet and in rat milk phospholipids, Lipids 9: 1030.
Galli, C., and Spagnuolo, C., 1976, The release of brain free fatty acids during ischemia in EFA deficient rats, J. Neurochem. 26: 401.
Galli, C., White, H. B., Jr., and Paoletti, R., 1970, Brain lipid modifications induced by essential fatty acid deficiency in growing male and female rats, J. Neurochem. 17: 347.
Galli, C., Trzeciak, H. I., and Paoletti, R., 1971, Effects of dietary fatty acids on the fatty acid composition of brain ethanolamine phosphoglyceride: Reciprocal replacement of n-6 and n-3 polyunsaturated fatty acids, Biochim. Biophys. Acta 248: 449.
Galli, C., Spagnuolo, C., Bosisio, E., Tosi, L., Folco, G. C., and Galli, G., 1978, Dietary essential fatty acids, polyunsaturated fatty acids and prostaglandins in the central nervous system, in Advances in Prostaglandin and Thromboxane Research, Vol. IV (F. Coceani and P. M. 011ey, eds.), p. 181, Raven Press, New York.
Gidez, L. I., and Feller, E., 1969, Effect of the stress of unilateral adrenalectomy on the depletion of individual cholesteryl esters in the rat adrenal, J. Lipid Res. 10: 656.
Guidotti, A., Cheney, D. L., Trabucchi, M., Doteuchi, M., Wang, C., and Hawkins, R. A., 1974, Focussed microwave radiation. A technique to minimize post-mortem changes of cyclic nucleotides, DOPA, and choline and to preserve brain morphology, Neuropharmacology 13: 1115.
Hamberg, M., and Samuelsson, B., 1974, Prostaglandin endoperoxides. VII. Novel transformation of arachidonic acid in guinea pig lung, Biochem. Biophys. Res. Commun. 61: 942.
Hamberg, M., Svensson, J., and Samuelsson, B., 1975, Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides, Proc. Natl. Acad. Sci. USA 72: 2994.
Hammarström, S., Murphy, R. C., and Samuelsson, B., 1979, Structure of leukotriene C: Identification of the amino acid part, Biochem. Biophys. Res. Comm. 91: 1266.
Hassam, A. G., Willis, A. L., Denton, J. P., Stevens, P., and Crawford, M. A., 1979, The effect of essential fatty acid deficient diet on the levels of prostaglandins and their fatty acid precursors in the rabbit brain, Lipids 14: 78.
Hill, E. E., and Lands, W. E. M., 1968, Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine, Biochim. Biophys. Acta 152: 645.
Hoffmann, P., Mentz, P., and Förster, W., 1977, Influence of linoleic acid supplemented diets on heart rate, contractile force coronary flow and prostaglandin release of rat hearts, J. Mol. Cell Cardiol. 9 (Suppl.): 21.
Holman, R. T., 1964, Nutritional and metabolic interrelationships between fatty acids, Fed. Proc. 23: 1062.
Holman, R. T., 1968, Essential fatty acid deficiency, in Progress in the Chemistry of Fats and Other Lipids, Vol. 9 ( R. T. Holman, ed.), p. 279, Pergamon Press, Oxford.
Holman, R. T., and Mohrhauer, H., 1963, A hypothesis involving competitive inhibitors in the metabolism of polyunsaturated fatty acids, Acta Chem. Scand. 17: 84.
Holman, R. T., and Peifer, J. J., 1960, Acceleration of essential fatty acid deficiency by dietary cholesterol, J. Nutr. 70: 411.
Hope, W. C., Dalton, C., Machlin, L. J., Filipski, R. J., and Vane, F. M., 1975, Influence of dietary vitamin E on prostaglandin biosynthesis in rat blood, Prostaglandins 10: 557.
Hornstra, G., 1975, Specific effects of types of dietary fat on arterial thrombosis, in The Role of Fats in Human Nutrition ( A. J. Vergroesen, ed.), p. 303, Academic Press, New York.
Homstra, G., and Haddeman, E., 1975, Essential fatty acid deficiency, a new model for basic research in thrombogenesis, Thromb. Dieth. Haemorrh. 34: 357.
Homstra, G., and Lussenburg, R. N., 1975, Relationship between the type of dietary fatty acid and arterial thrombosis tendency in rats, Atherosclerosis 22: 499.
Homstra, G., Lewis, B., Chait, A., Turpeinen, O., Karvonen, M. S., and Vergroesen, A. J., 1973, Influence of dietary fat on platelet function in men, Lancet 1: 1155.
Hornstra, G., Haddeman, E., and Don, J. A., 1978, Some investigations into the role of prostacyclin in thromboregulation, Thromb. Res. 12: 367.
Houtsmuller, A. J., 1975, The role of fats in the treatment of diabetes mellitus, in The Role of Fat in Human Nutrition ( A. J. Vergroesen, ed.), p. 231, Academic Press, London.
Hulan, H. W., and Kramer, J. K. G., 1977, The effect of long-chain monoenes on prostaglandin E2 synthesis by rat skin, Lipids 12: 604.
Hwang, D. H., and Kinsella, J. E., 1978, The effects of trans linoleic acid on the concentration of serum prostaglandin F2 and platelet aggregation, Prostaglandins Med. 1: 21.
Hwang, D. H., Mathias, M. M., Dupont, J., and Meyer, D. L., 1975, Linoleate enrichment of diet and prostaglandin metabolism in rats, J. Nutr. 105: 995.
Iacono, J. M., Binder, R. A., Marshall, M. W., Schoene, N. W., Jencks, J. A., and Mackin, J. F., 1974, Decreased susceptibility to thrombin and collagen of platelet aggregation in man fed a low fat diet, Haemostasis 3: 306.
Iacono, J. M., Marshall, M. W., Dougherty, R. M., Wheeler, M. A., Mackin, J. F., and Canary, J. J., 1975, Reduction in blood pressure associated with high polyunsaturated fat diets that reduce cholesterol in man, Prey. Med. 4: 426.
Iacono, J. M., Doughtery, R., Paoletti, R., Galli, C., Carvalho, A. C. A., Ferro-Luzzi, A., Therriault, D. G., Nelson, G., and Keys, A., 1978, Pilot epidemiological studies in thrombosis, in The Thrombotic Process in Atherogenesis ( A. B. Chandler, K. Eurenius, G. C. McMillan, C. B. Nelson, C. J. Schwartz, and S. Wessler, eds.), p. 309, Plenum Press, New York.
Isakson, P. C., Raz, A., and Needleman, P., 1976, Selective incorporation of arachidonic acid into the phospholipids of intact tissues and subsequent metabolism to “C prostaglandins, Prostaglandins 12: 739.
Jaeger, F. C., 1970, Effect of fatty acids on the contraction of guinea-pig ileum in vitro, Experientia 26: 731.
Johnson, M., Reece, A., and Harrison, N., 1980, An imbalance in arachidonic acid metabolism in diabetes, in Advances in Prostaglandin and Thromboxane Research, Vol. 8 ( B. Samuelsson, P. Ramwell, and R. Paoletti, eds.), p. 1283, Raven Press, New York.
Kaa, E., 1976, In vitro biosynthesis of PGE2 by kidney medulla of essential fatty acid deficient rats, Lipids 11: 693.
Kernoff, P. B., Willis, A. L., Stone, K. J., Davies, J. A., McNicol, G. P., 1977, Anti-thrombotic potential of di-homo-gamma-linolenic acid in man, Br. Med. J. 2 (6100): 1441.
Keys, A., 1975, Coronary heart disease—The global picture, Atherosclerosis 22: 149.
Kupiecki, F. P., Sekhar, N. C., and Weeks, J. R., 1968, Effects of infusion of some prostaglandins in essential fatty acid deficient and normal rats, J. Lipid Res. 9: 602.
Lagarde, M., Gharib, A., and Dechavanne, M., 1977, Different utilization of arachidonic and dihomogammalinolenic acids by human platelet prostaglandin synthesis, Biochimie 59: 935.
Lands, W. E. M., Blank, M. L., Nutter, L. J., and Privett, O. S., 1966, A comparison of acyltransferase activities in vitro with the distribution of fatty acids in lecithins and triglycerides in vivo, Lipids 1: 224.
Lapetina, E. G., and Cuatrecasas, P., 1979, Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin, Biochim. Biophys. Acta 573: 394.
Lapetina, E. G., Schmitges, C. J., Chandrabose, K., and Cuatrecasas, P., 1977, Cyclic adenosine 3’-5’-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets, Biochem. Biophys. Res. Comm. 76: 828.
Lipinski, B. A., and Mathias, M. M., 1978, Prostaglandin production and lipolysis in isolated rat adipocytes as affected by dietary fat, Prostaglandins 16: 957.
McCosh, E. J., Meyer, D. J., and Dupont, J., 1976, Radioimmunoassay of prostaglandins E1, E2 and F2 in unextracted plasma, serum and myocardium, Prostaglandins 12: 471.
McGiff, J. G., and Malik, K. U., 1976, Renal prostaglandins, in Prostaglandins, Physiological, Pharmacological and Pathological Aspects ( S. M. M. Karim, ed.), p. 201, M.T.P., Lancaster, England.
McGregor, L., and Renaud, S., 1978, Effect of dietary linoleic acid deficiency on platelet aggregation and phospholipid fatty acids of rats, Thromb. Res. 12: 921.
Maddox, I. S., 1973, The role of copper in prostaglandin synthesis, Biochim. Biophys. Acta 306:74. Mathias, M. M., and Dupont, J., 1979, The relationship of dietary fats to prostaglandin biosynthesis, Lipids 14: 247.
Mattson, R. H., 1960, An investigation of the essential fatty acid activity of some of the geometrical isomers of unsaturated fatty acids, J. Nutr. 71: 366.
Mead, J. F., 1968, The metabolism of polyunsaturated fatty acids, in Progress in the Chemistry of Fats and Other Lipids, Vol. 9 (R. T. Holman, ed.), p. 161, Pergamon Press, Oxford.
Mentz, P., and Föster, W., 1977, The influence of unsaturated fatty acids on prostaglandin release in isolated perfused guinea-pig hearts, Prostaglandins 14: 173.
Mertin, J., Hughues, D., Shenton, B. K., and Field, E. J., 1973, Unsaturated fatty acids in multiple sclerosis, Br. Med. J. 2: 777.
Mest, H. J., Bless, K. E., and Föster, W., 1977, Effects of arachidonic, linoleic, linolenic and oleic acid on experimental arrhythmias in cats, rabbits and guinea-pigs, Prostaglandins 14: 163.
Meydani, S., Mathias, M., and Schatte, C., 1978, Dietary trait and ambient oxygen tension influence pulmonary prostaglandin synthetic potential, Prostaglandins Med. 1: 241.
Michell, R. H., 1975, Inositol phospholipids and cell surface receptors function, Biochim. Biophys. Acta 415: 81.
Millar, A. H. D., Zilkha, K. J., Langman, M. J. S., Wright, H. P., Smith, A. D., Berlin, J., and Thompson, R. H. S., 1973, Double-blind trial of linoleate supplementation of the diet in multiple sclerosis, Br. Med. J. 1: 765.
Miller, N. E., Forde, O. H., Thelle, D. S., and Mjos, O. D., 1977, The Tromso heart-study. High density lipoprotein and coronary heart-disease: A prospective case-control study, Lancet 1: 965.
Miyamoto, T., Yamamoto, S., and Hayaishi, 0., 1974, Prostaglandin synthetase system-resolution into oxygenase and isomerase components, Proc. Natl. Acad. Sci. 71: 3645.
Miyamoto, T., Ogino, N., Yamamoto, S., and Hayaishi, 0., 1976, Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes, J. Biol. Chem. 251: 2629.
Mohrhauer, H., and Holman, R. T., 1963, Effect of linolenic acid upon the metabolism of linoleic acid, J. Nutr. 81: 67.
Mohrhauer, H., Rahm, J. J., Seufert, J., and Holman, R. T., 1967, Metabolism of linoleic acid in relation to dietary monoenoic fatty acids in the rat, J. Nutr. 91: 521.
Needleman, P., Sprecher, H., Whitaker, M. O., and Wyche, A., 1980, Mechanism underlying the inhibiton of platelet aggregation by eicosapentaenoic acid and its metabolites, in Advances in Prostaglandin and Thromboxane Research, Vol. 6 ( B. Samuelsson, P. Ramwell, and R. Paoletti, eds.), p. 61, Raven Press, New York.
Nicosia, S., and Galli, G., 1975, A mass fragmentographic method for the quantitative evaluation of brain prostaglandin biosynthesis, Prostaglandins 9: 397.
Nugteren, D. H., 1970, Inhibition of prostaglandin biosynthesis of 8cis, 12trans, l4ciseicosatrienoic acid and 5cis, 8cis, 12trans, 14cis eicosatetraenoic acid, Biochim. Biophys. Acta 210: 171.
Nugteren, D. H., Beerthuis, R. K., and Van Dorp, O. A., 1966, The enzymic conversion of all-cis-8,11,14-eicosatrienoic acid into prostaglandin E1, Red. Tray. Chim. 85: 405.
Nugteren, D. H., and Hazelhof, E., 1973, Isolation and properties of intermediates in prostaglandin biosynthesis, Biochim. Biophys. Acta 326: 448.
O’Brien, J. R., Etherington, M. D., Jamieson, S., Vergroesen, A. J., and ten Hoor, F., 1976, Effect of a diet of polyunsaturated fats on some platelet-function tests, Lancet 2: 995.
Oelz, O., Seyberth, H. W., Knapp, H. R., Jr., Sweetman, B. J., and Oates, J. A., 1976, Effects of feeding ethyl-dihomo-y-linoleate on prostaglandin biosynthesis and platelet aggregation in the rabbit, Biochim. Biophys. Acta 431: 268.
Pace-Asciak, C., and Wolfe, L. S., 1968, Inhibition of prostaglandin synthesis by oleic, linoleic acid and linolenic acids, Biochim. Biophys. Acta 152: 784.
Panganamala, R. V., Miller, J. S., Gwebu, E. T., Sharma, H. M., and Cornwell, D. G., 1977, Differential inhibitory effects of vitamin E and other antioxidants on prostaglandin synthetase, platelet aggregation and lipoxidase, Prostaglandins 14: 261.
Paoletti, R., and Puglisi, C., 1973, Prostaglandins and lipid metabolism, in The Prostaglandins, Vol. 1 ( P. W. Ramwell, ed.), p. 317, Plenum Press, New York.
Pamham, M. J., Vincent, J. E., Zijlstra, F. J., and Bonta, I. L., 1979, The use of essential fatty acid deficient rats to study pathophysiological roles of prostaglandins. Comparison of prostaglandin production with some parameters of deficiency, Lipids 14: 407.
Peifer, J. J., and Holman, R. T., 1955, Essential fatty acids, diabetes and cholesterol, Arch. Biochem. Biophys. 57: 520.
Privett, O. S., Steams, E. M., Jr., and Nickell, E. C., 1967, Metabolism of the geometric isomers of linoleic acid in the rat, J. Nutr. 92: 303.
Privett, O. S., Phillips, F., Fukazawa, T., Kaltenbach, C. C., and Sprecher, H. W., 1972, Studies on the relationship of the synthesis of prostaglandins to the biological activity of essential fatty acids, Biochim. Biophys. Acta 280: 348.
Puglisi, L., Berti, F., Bosisio, E., Longiave, D., and Nicosia, S., 1976, Ascorbic acid and PGF2,, antagonism on tracheal smooth muscle, in Advances in Prostaglandin and Thromboxane Research, Vol. 1 ( B. Samuelsson and R. Paoletti, eds.), p. 503, Raven Press, New York.
Ramwell, P. W., and Shaw, J. E., 1970, Biological significance of the prostaglandins, Recent Prog. Horm. Res. 26: 139.
Ramwell, P. W., Leovey, E. M. K., and Sintetos, A. L., 1977, Regulation of the arachidonic acid cascade, Biol. Reprod. 16: 70.
Rao, G. H. R., Gerrard, J. M., Eaton, J. W., Clawson, C. C., and White, J. G., 1978, The role of iron in prostaglandin synthesis: Ferrous iron mediated oxidation of arachidonic acid, Fed. Proc. 37 (3): 259.
Reitz, R. C., Lands, W. E. M., Christie, W. W., and Holman, R. T., 1968, Effects of ethylenic bond position upon acyltransferase activity with isomeric cis, cis-octadecadien-oyl coenzyme a thiol esters, J. Biol. Chem. 243: 2241.
Renaud, S., and Le Compte, F., 1970, Hypercoagulability induced by hyperlipemia in rat, rabbit and man, Circ. Res. 27: 1003.
Renaud, S., and Gautheron, P., 1973/1974, Dietary fats and experimental (cardiac and venous) thrombosis, Haemostasis 2: 53.
Robak, J., Dembinska-Kiec, A., and Gryglewski, R., 1975, The influence of saturated fatty acids on prostaglandin synthetase activity, Biochem. Pharmacol. 24: 2057.
Roland, D. A., Jr., and Edwards, H. M., Jr., 1971, Effect of essential fatty acid deficiency and type of dietary fat supplementation of biotin-deficient chicks, J. Nutr. 101: 811.
Rose, J. C., Johnson, M., Ramwell, P. W., and Kot, P. A., 1974, Effects of arachidonic acid on systemic arterial pressure, myocardial contractility and platelets in the dog, Proc. Soc. Exp. Biol. Med. 147: 652.
Rosenthal, J., Simone, P. G., and Silbergleit, A., 1974, Effects of prostaglandin deficiency on natriuresis, diuresis and blood pressure, Prostaglandins 5: 435.
Samuelsson, B., Hamberg, M., Malmsten, C., and Svensson, J., 1976, The role of prostaglandin endoperoxides and thromboxanes in platelet aggregation, in Advances in Prostaglandin and Thromboxane Research, Vol. 1 ( B. Samuelsson and R. Paoletti, eds.), p. 737, Raven Press, New York.
Schoene, N. W., and Iacono, J. M., 1975, Stimulation of platelet phospholipase A2 activity by aggregating agents, Fed. Proc. 34: 257.
Seyberth, H. W., Oelz, 0., Kennedy, T., Sweetman, B. J., Danon, A., Frölich, J. C., Heimberg, M., and Oates, J. A., 1975, Increased arachidonate in lipids after administration to man: Effects on prostaglandin biosynthesis, Clin. Pharmacol. Ther. 18: 521.
Sim, A. K., and McCraw, A. P., 1977, The activity of gamma linoleate and di-homo-gammalinolenate methyl esters in vitro and in vivo on blood platelet function in non-human primates and in man, Thromb. Res. 10: 385.
Smith, W. L., and Lands, W. E. M., 1972, Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular gland, Biochemistry 11: 3276.
Sprecher, H., 1977, Biosynthesis of polyunsaturated fatty acids and its regulation, in Polyunsaturated Fatty Acids ( W. H. Kunau and R. T. Holman, eds.), p. 1, American Oil Chemists’ Society, Champaign, Ill.
Stahl, R. A. K., Attallah, A. A., Bloch, D. L., and Lee, J. B., 1980, Stimulation of rabbit renal PGE2 biosynthesis by dietary restriction of sodium, in Advances in Prostaglandin and Thromboxane Research, Vol. 8 (B. Samuelsson, P. Ramwell, and R. Paoletti, eds.), p. 1053, Raven Press, New York.
Stegink, L. D., Freeman, J. B., Wispe, J., and Connor, W. E., 1977, Absence of the biochemical symptoms of essential fatty acid deficiency in surgical patients undergoing protein sparing therapy, Am. J. Clin. Nutr. 30: 388.
Struijk, C. B Beerthuis, R. K., Pabon, H. J. J and Van Dorp, D. A., 1966, Specificity in the enzymic conversion of polyunsaturated fatty acids into prostaglandins, Recl. Tray. Chim. 85:1233.
Svennerholm, L., 1968, Distribution and fatty acid composition of phosphoglycerides in normal human brain, J. Lipid Res. 9: 570.
Tan, W. C., and Privett, O. S., 1973, Studies on the synthesis of prostaglandins in the vesicular glands of essential fatty acid deficient and hypophysectomized rats, Biochim. Biophys. Acta 296:586.
ten Hoor, F., de Deckere, E. A. M., Haddeman, E., Homstra, G., and Quadt, J. F. A., 1980, Dietary manipulation of prostaglandin and thromboxane synthesis in heart, aorta and blood platelets of the rat, in Advances in Prostaglandin and Thromboxane Research, Vol. 8 (B. Samuelsson, P. Ramwell, and R. Paoletti, eds.), p. 1771, Raven Press, New York.
Triebe, G., Block, H. U., and Förster, W., 1976, On the blood pressure response of salt loaded rats under different content of linoleic acid in the food, Acta Biol. Med. Ger. 35: 1225.
Tucker, S. B., Schroeter, A. L., Brown, P. W., Jr., and McCall, J. T., 1976, Acquired zinc deficiency. Cutaneous manifestations typical of acrodermatitis enteropathica, J. Am. Med. Assoc. 235: 2399.
Tuna, N., Frankhauser, S., and Goetz, F. G., 1968, Total serum fatty acids in diabetes: Relative and absolute concentrations of individual fatty acids, Am. J. Med. Sci. 255: 120.
Van Dorp, D. A., 1971, Recent developments in the biosynthesis and the analyses of prostaglandins, Ann. N.Y. Acad. Sci. 180: 181.
Van Evert, W. C., Nugteren, D. H., and Van Dorp, D. A., 1978, Inhibition of prostaglandin biosynthesis by c-5, c-8, c-11 eicosatrienoic acid, Prostaglandins, 15: 267.
Vincent, J. E., Zijlstra, F. J., and Bonta, I. L., 1975, The effect of non-steroid anti-inflammatory drugs, dibutyryl cyclic 3’,5’-adenosine monophosphate and phosphodiesterase inhibitors on platelet aggregation and the platelet release reaction in normal and essential fatty acid deficient rats, Prostaglandins 10: 899.
Vincent, J. E., and Zijlstra, F. J., 1977, Formation by phospholipase A2 of prostaglandins and thromboxane A2-like activity in the platelets of normal and essential fatty acid deficient diets. Comparison with the effect on human and rabbit platelets, Prostaglandins 14:1043.
Weston, P. G., and Johnston, P. V., 1978, Cerebral prostaglandin synthesis during the dietary and pathological stresses of essential fatty acid deficiency and experimental allergic encephalomyelitis, Lipids 13: 408.
Wheeler, T. G., Benolken, R. M., and Anderson, R. E., 1975, Visual membranes. Specificity of fatty acid precursors for the electrical response to illumination, Science 188:1312.
Wicks, T. C., Rose, J. C., Johnson, M., Ramwell, P. W., and Kot, P. A., 1976, Vascular responses to arachidonic acid in the perfused canine lung, Circ. Res. 38:167.
Witten, P. W., and Holman, R. T., 1953, Polyethenoid fatty acid metabolism, IV. Effect on pyridoxine on essential fatty acid conversions, Arch. Biochem. Biophys. 41: 266.
Witting, L. A., 1970, The interrelationship of polyunsaturated fatty acids and anti-oxidants in vivo, 126 Claudio Galli in Progress in the Chemistry of Fats and Other Lipids, Vol. 9 (R. T. Holman, ed.), p. 519, Pergamon Press, New York.
Wolfe, L. S., Pappius, H. M., and Marion, J., 1976, The Biosynthesis of prostaglandins by brain tissues in vitro, in Advances in Prostaglandin and Thromboxane Research, Vol. 1 (B. Samuelsson and R. Paoletti, eds.), p. 345, Raven Press, New York.
Wood, R., and Wiegard, R. D., 1975, Hepatoma, host liver, and normal rat liver lipids: Distribution of isomeric monoene fatty acids in individual lipid classes, Lipids 10: 746.
Yoshimoto, A., Ito, H., and Tornita, J., 1970, Cofactor requirements of the enzyme synthesizing prostaglandin in bovine seminal vesicles, J. Biochem. 68: 487.
Zehaluk, C. M., and Walker, B. L., 1973, Effect of pyridoxine on red cell fatty acid composition in mature rats fed on essential fatty acid-deficient diet, J. Nutr. 103: 1548.
Ziboh, V. A., 1973, Biosynthesis of prostaglandin E2 in human skin: subcellular localization and inhibition by unsaturated fatty acids and anti-inflammatory drugs, J. Lipid Res. 14: 377.
Ziboh, V. A., 1975, Regulation of prostaglandin E2 biosynthesis in guinea pig skin by retinoic acid, Acta Derm. Venereol. (Suppl.) (Stockholm) 74: 56.
Ziboh, V. A., and Hsia, S. L., 1972, Effects of prostaglandin E2 on rat skin: inhibition of sterol ester biosynthesis and clearing of scaly lesions in essential fatty acid deficiency, J. Lipid Res. 13: 458.
Ziboh, V. A., Vanderhoek, J. J., and Lands, W. E. M., 1974, Inhibition of sheep vesicular gland oxygenase by unsaturated fatty acids from skin of essential fatty acid deficient rats, Prostaglandins 5:233.
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Galli, C. (1980). Dietary Influences on Prostaglandin Synthesis. In: Draper, H.H. (eds) Advances in Nutritional Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4448-4_4
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