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Advances in Nutritional Research pp 301–353Cite as

Trichothecene Mycotoxins Mycology, Chemistry, and Toxicology

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Abstract

The mycotoxins reviewed in this section comprise a family of closely related sesquiterpenoids produced by various species of fungi such as Fusarium, Myrothecium, Trichoderma, Trichothecium, Cephalosporium, Verticimonosporium and Stachybotrys,and are classified as trichothecenes after trichothecin, the first member of the group to be discovered (Freeman and Morrison, 1949). In the early stage of trichothecene studies, the first isolate, trichothecin, was discovered as a result of screening of antifungal metabolites in a culture of Trichothecium roseum. The following survey demonstrated that Myrothecium roridum and M. verrucaria produced potent antifungal metabolites, which were designated as verrucarins A through J and rondins A through E (Härri et al.,1962). Structural studies on these compounds demonstrated that they are macrocyclic trichothecenes (Böhner et al., 1965).

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  1. Department of Toxicology and Microbial Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan

    Yoshio Ueno

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  1. University of Guelph, Guelph, Ontario, Canada

    Harold H. Draper

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Ueno, Y. (1980). Trichothecene Mycotoxins Mycology, Chemistry, and Toxicology. In: Draper, H.H. (eds) Advances in Nutritional Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4448-4_10

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