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Myocardial Energy Metabolism of Congestive and Hypertrophic Cardiomyopathy in Man

  • H. Abe
  • T. Yamada
  • K. Miyata
  • A. Yoshida
  • Y. Yabe

Abstract

A key enzyme of glycolysis (pyruvate kinase) and main enzymes of the electron transport system (NADH cytochrome c reductase, succinic cytochrome c reductase, and cytochrome c oxidase) were measured in left ventricular biopsy specimens from six hypertrophic (HCM) and six congestive (CCM) cardiomyopathy. Pyruvate kinase was 104.0 and 45.0 mU/ mg protein in HCM and CCM, respectively. NADH cytochrome c reductase, succinic cytochrome c reductase, and cytochrome c oxidase were 146.0, 9.9, and 775.0 mU/mg protein in HCM and 87.4, 5.2, and 502.0 mU/mg protein in CCM, respectively. From these data, it is evident that glycolysis and enzyme activities of the electron transport system are increased in HCM and decreased in CCM. Cardiac function reflects the state of these energy metabolism pathways in the myocardium. The changing energy metabolism in the right ventricle of the emphysema hamster seems to support this concept.

Keywords

Hypertrophic Cardiomyopathy Pyruvate Kinase Electron Transport System Ventricular Overload Myocardial Energy Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • H. Abe
    • 1
  • T. Yamada
    • 2
  • K. Miyata
    • 2
  • A. Yoshida
    • 2
  • Y. Yabe
    • 3
  1. 1.Department of RadiologyNihon University School of MedicineTokyoJapan
  2. 2.Department of Internal MedicineJosai Dental UniversitySaitamaJapan
  3. 3.Cardiovascular Diagnostic Laboratory CenterToho University School of MedicineTokyoJapan

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