Biopsy Assessment of Preservation during Open-Heart Surgery with Cold Cardioplegic Arrest

  • S. C̄anković-Darracott
  • M. V. Braimbridge
  • J. Chayen


The efficacy of cold cardioplegic arrest as a method of myocardial preservation has been evaluated by cytochemical and biophysical assessments made on needle biopsies taken from 150 patients undergoing open-heart surgery (e.g., aortic valve replacement, aortic and mitral valve replacement, mitral valve replacement, coronary artery bypass graft, repair of atrial or ventricular septal defects). Comparison of endo- and epicardial preservation showed improved endocardial preservation with cardioplegia compared with that achieved with the previous method used—continuous coronary perfusion at 32°C; however, care had to be taken to ensure adequate cooling of the epicardium. Biopsies also showed the need for repeated infusions of cardioplegie solution if the aorta was occluded for more than 70 min. Preservation of right and left ventricle has also been compared.


Valve Replacement Aortic Valve Replacement Ventricular Septal Defect Mitral Valve Replacement Mitral Valve Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Braimbridge, M. V., and Cankovic-Darracott, S. 1979. Quantitative polarisation microscopy and cytochemistry in assessing myocardial function. In: J. R. Pattison, L. Bitensky, and J. Chayen (eds.), Quantitative Cytochemistry and its Applications, pp. 221–230. Academic Press, New York, London.Google Scholar
  2. 2.
    Braimbridge, M. V., Chayen, J., Bitensky, L., Hearse, D. J., Jynge, P., and Cankovic-Darracott, S. 1977. Cold cardioplegia or continuous coronary perfusion? J. Thorac. Car-diovasc. Surg.74:900–906.Google Scholar
  3. 3.
    Buckberg, G. 1972. Subendocardial ischemia after cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg.64:669–684.PubMedGoogle Scholar
  4. 4.
    Cankovié-Darracott, S., Braimbridge, M. V., Williams, B. T., Bitensky, L., and Chayen, J. 1977. Myocardial preservation during aortic valve surgery. Assessment of five techniques by cellular chemical and biophysical methods. J. Thorac. Cardiovasc. Surg.73:699–706.Google Scholar
  5. 5.
    Chayen, J., Bitensky, L., and Butcher, R. G. (eds.) 1973. Practical Histochemistry, pp. 85–192. John Wiley & Sons, New York.Google Scholar
  6. 6.
    Kolettis, M., Jenkins, B. S., and Webb-Peploe, M. M. 1976. Assessment of left ventricular function by indices derived from aortic flow velocity. Br. Heart J.38:18–31.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • S. C̄anković-Darracott
    • 1
  • M. V. Braimbridge
    • 1
  • J. Chayen
    • 2
  1. 1.Department of Heart Research (Surgical Cytochemistry), The Rayne InstituteSt. Thomas’ HospitalLondon SE1England
  2. 2.Division of Cellular BiologyKennedy Institute of RheumatologyLondonEngland

Personalised recommendations