Hypoxia, Calcium, and Contracture as Mediators of Myocardial Enzyme Release
During calcium-free perfusion, anoxic contracture of myocardial cells causes cells to separate at intercalated disks and leads to an energy-independent enzyme release in the absence of active transmembrane calcium fluxes. It is proposed that contracture mediates membrane damage and enzyme release in cells sensitized to the calcium paradox.
KeywordsEnzyme Release Intercalate Disk Membrane Injury Sarcolemmal Membrane Calcium Paradox
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