Immunologic Studies in Infective Endocarditis

  • P. L. Wahi
  • K. K. Talwar
  • N. K. Ganguly
  • A. K. Khanna
  • P. S. Bidwai
  • I. S. Anand


Some immunologic changes in patients with infective endocarditis were measured during therapy with antibiotics. T cells and C3 levels were low in 29 and 59% of the subjects, respectively. The circulating immune complexes were high and showed a negative correlation with serum C3 levels. Teichoic acid antibodies with titer of above 5 were generally seen only in cases of bacteremia in which endothelial damage had taken place. The antibody was specific for gram-positive organisms because it was negative in gram-negative bacteremia. The antibody showed a fall during treatment and hence could be used to monitor efficacy of antibiotic therapy.


Immune Complex Infective Endocarditis Rheumatic Heart Disease Teichoic Acid Thymidine Uptake 
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  1. 1.
    Arnold, S. B., Valone, J. A., Askenas, P. L., Kashgarian, M., and Freedman, L. R. 1975. Diffuse glomerulonephritis in rabbits with Streptococcus viridansendocarditis. Lab. Invest. 32:681.PubMedGoogle Scholar
  2. 2.
    Boulton-Jones, J. M., Sissons, J. G. P., Evans, D. J., and Peters, D. K. 1974. Renal lesions of subacute infective endocarditis. Br. Med. J. 2:11–14.PubMedCrossRefGoogle Scholar
  3. 3.
    Cabne, J., Godeau, P., Hereman, G., Acar, J., Digeon, M. and Francois, J. 1979. Fate of circulating immune complexes in infective endocarditis. Am. J. Med. 66:277–282.CrossRefGoogle Scholar
  4. 4.
    Cole, P. 1975. The engima of infective endocarditis. Hosp. Update1:128–138.Google Scholar
  5. 5.
    Creighton, W. D., Lambert, P. H., and Miescher, P. A. 1973. Detection of antibodies and soluble antigen-antibody complexes by precipitation with polyethylene glycol. J. Immunol. 111:1219–1227.PubMedGoogle Scholar
  6. 6.
    Elliott, S. D., McCarty, M., and Sancefield, R. C. 1977. Teichoic acids of group D streptococci with special reference to strains from pig meningitis. J. Exp. Med. 145:490.PubMedCrossRefGoogle Scholar
  7. 7.
    Ganguly, N. K., Mohan, C., Sapru, R. P., and Kumar, M. 1977. T and B cell populations in the peripheral blood of rhesus monkeys. Int. Arch. Allergy Appl. Immunol. 53:290.PubMedCrossRefGoogle Scholar
  8. 8.
    Gutman, R. A., Striker, G. E., Gilliland, B. C.I and Cutler, R. E. 1972. The immune complex glomerulonephritis of bacterial endocarditis. Medicine (Baltimore)51:1–25.CrossRefGoogle Scholar
  9. 9.
    Hereman, G., Godean, P., Cabane, J., et al. 1975. Etude immunologique des endocarditis infectieuses subaigiues par recherche de complexes immune circulants. Nouv. Presse Med. 4:2311.Google Scholar
  10. 10.
    Hurwitz, D., Quismorio, F. P., and Friou, G. 1975. Cryoglobulinemia in patients with infective endocarditis. Clin. Exp. Immunol. 19:131.PubMedGoogle Scholar
  11. 11.
    Keslin, M. H., Messner, R. P., and Williams, R. C., Jr. 1973. Glomerulonephritis with subacute bacterial endocarditis. Arch. Intern. Med. 132:578–581.PubMedCrossRefGoogle Scholar
  12. 12.
    Lachman, P. J., and Thompson, R. A. 1970. Reactive lysis: The complement mediated lysis of unsensitized cell 11. The characterisation of activated factor as C 56 and the participation of C8 and C9. J. Exp. Med. 4:643.CrossRefGoogle Scholar
  13. 13.
    Laxdal, T., Messner, R. P., Williams, R. C., Jr., and Quie, P. G. 1968. Opsonic agglutinating and complement fixing antibodies in patients with subacute bacterial endocarditis. J. Lab. Clin. Med. 71:638.PubMedGoogle Scholar
  14. 14.
    Mancini, G., Carbonara, A. O., and Heremans, J. F. 1965. Immunochemical quantitation of antigens by single radial immunodiffusion. Int. J. Immunochem. 2:235–254.CrossRefGoogle Scholar
  15. 15.
    Mohammed, I., Thompson, B., and Holborow, E. J. 1977. Radiobioassay for immune complexes using macrophages. Ann. Rheum. Dis. 36(Suppl. 1):49.Google Scholar
  16. 16.
    Moskowitz, M. 1966. Separation and properties of red cell sensitizing substances from streptococci. J. Bacteriol. 91(6):2200–2204.PubMedGoogle Scholar
  17. 17.
    Sapru, R. P., Ganguly, N. K., Sharma, S., Chandnani, R. E., and Gupta, A. K. 1977. Cellular reaction to group A beta haemolytic streptococcal membrane antigen and its relation to complement levels in patients with rheumatic heart disease. Br. Med. J. 2:422–424.PubMedCrossRefGoogle Scholar
  18. 18.
    William, R. R., Jr., and Kunkel, H. 1962. Rheumatoid factor complement and conglutinin abberrations in patients with subacute bacterial endocarditis. J. Clin. Invest. 41:666.CrossRefGoogle Scholar
  19. 19.
    Williams, R. C., Jr. 1958. Serum complement in connection with tissue disorders. J. Lab. Clin. Med. 52:273.PubMedGoogle Scholar
  20. 20.
    Zubler, R. H., Lange, G., Lambert, P. H., and Miescher, P. A. 1976. Detection of immunecomplexes in unheated sera by a modified 125 Clq binding test. Effect of heating on the binding of Clq by immune complexes and application of test to systemic lupus erythematosus. J. Immunol. 116:232–235.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1983

Authors and Affiliations

  • P. L. Wahi
    • 1
  • K. K. Talwar
    • 1
  • N. K. Ganguly
    • 1
  • A. K. Khanna
    • 1
  • P. S. Bidwai
    • 1
  • I. S. Anand
    • 1
  1. 1.Departments of Cardiology and ParasitologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia

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