Vasoactive Peptides and Regulation of Hemodynamics in Different Functional States of the Organism

  • A. M. Chernukh
  • O. A. Gomazkov


It is important to emphasize that the biochemical systems participating in humoral hemodynamic regulation may function at any level of the circulatory homeostasis: in the blood as a biological fluid constantly circulating along the vessels, at the microcirculatory bed where the exchange with tissues is realized, on the tonic activity of the resistive and capacitance vessels, defining the systemic blood pressure rate and organ redistribution, or, finally, on the main motive force of the blood, the heart. The interrelations of some molecular factors form the biochemical basis for the interaction of the main humoral systems. These factors are kallikrein for kinins and converting enzyme for the renin-angiotensin system, 9-ketoreductase and phospholipase for kinin and prostaglandin systems, and Hageman factors for coagulation, fibrinolysis, and kininogenesis systems. This main scheme includes “functional” connections, which are defined by a physiological interaction, and those between the central and peripheral nervous systems. We may, evidently, postulate an important biological regularity of a multifunctional participation of the same physiologically active factors in maintaining circulatory homeostasis. On the other hand, we have to emphasize the functional unity and joint correlating actions of different biochemical blood systems.


Vasoactive Peptide High Molecular Weight Kininogen Vessel Tonus Raster Electron Microscopy Hemodynamic Regulation 
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  1. 1.
    Chernukh, A. M., Alexeyev, O. V., and Ionov, B. V. 1981. [Interaction of erythrocytes in aggregation according to raster electron microscopy.] Biull. Eksp. Biol. Med. 2:226–228.Google Scholar
  2. 2.
    Chernukh, A. M., and Gomazkov, O. A. 1976. [On regularity and pathogenetic role of kallikrein-kinin system of organism.] Patol. Fisiol. Eksp. Ther. 1:5–16.Google Scholar
  3. 3.
    Chernukh, A. M., Gomazkov, O. A., Komissarova, N. V., and Lantsberg, L. 1981. [Changes in indices of Hageman factor system in human adaptation to intensive physical exercise.] Patol. Fisiol. Eksp. Ther. 5:25–28.Google Scholar
  4. 4.
    Chernukh, A. M., Oehme, P., and Gomazkov, O. A. 1980. [Hemodynamic characteristics of the polypeptide substance P in comparison with bradykinin and prostaglandin E1.] Biull. Eksp. Biol. Med. 9:259–260.Google Scholar
  5. 5.
    Derkx, F. H., Bouma, B. N., and Schalekamp, M. 1979. An intrinsic factor XII-prekallikrein-dependent pathways activates the human plasma renin-angiotensin system. Nature280:315–316.PubMedCrossRefGoogle Scholar
  6. 6.
    Donaldson, V. H., Kleniewski, J., Saito, H., and Sayed, J. K. 1977. Prekallikreindeficiency and Fitzgerald trait clotting defect. Evidence that high molecular weight kininogen and prekallikrein exist as a complex in normal human plasma. J. Clin. Invest. 60:571–584.PubMedCrossRefGoogle Scholar
  7. 7.
    Eliseeva, T. E., and Orekhovitch, V. N. 1963. [Isolation and study of specificity of carboxycathepsin.] Dokl. Akad. Nauk. SSSR153:954–956.Google Scholar
  8. 8.
    Frey, E. K., and Kraut, H. 1928. Ein neues Kreislaufhormon und seine Wirkung. Arch. Exp. Pathol. Pharmacol. 133:1–56.CrossRefGoogle Scholar
  9. 9.
    Frey, E. K., Kraut, H., and Werle, E. 1950. Kallikrein (Padutin). Enke, Stuttgart.Google Scholar
  10. 10.
    Gomazkov, O. A. 1973. [Vasoactive kinins in physiology and pathology of cardiovascular system.] Kardiologiia7:130–144.Google Scholar
  11. 11.
    Gomazkov, O. A. 1974. Das Kallikrein-Klinin-System bei Myokardischemie und Herzinfarct—Experimentelle Untersuchungen. Med. Welt25:804–807.PubMedGoogle Scholar
  12. 12.
    Gomazkov, O. A., and Komissarova, N. V. 1976. [Method of simultaneous determination of precursors of kallikrein, plasmin, thrombin and their inhibitors in human blood plasma.] Biull. Eksp. Biol. Med. 5:632–634.Google Scholar
  13. 13.
    Gomazkov, O. A., Shimkovitch, M. V., and Chernukh, A. M. 1977. [Interrelation between kininase and angiotensin-converting activity under normal condition and in experimentally induced myocardial infarction.] Kardiologiia17:103–108.PubMedGoogle Scholar
  14. 14.
    Gordon, R. J. 1974. Potential significance of plasma viscosity and hematocrit variations in myocardial ischemia. Am. Heart J. 87:175–182.PubMedCrossRefGoogle Scholar
  15. 15.
    Griffin, J. 1978. Role of surface in surface-dependent activation of Hageman factor (blood coagulation factor XII). Proc. Natl. Acad. Sci. U.S.A. 75:1998–2002.PubMedCrossRefGoogle Scholar
  16. 16.
    Meier, H. L., Pierce, J. V., Colman, R. W., and Kaplan, A. P. 1977. Activation and function of human Hageman factor. The role of high molecular weight kininogen and prekallikrein. J. Clin. Invest. 60:18–31.PubMedCrossRefGoogle Scholar
  17. 17.
    Moncada, S., Mullane, K. M., and Vane, J. R. 1979. Prostacycline release by bradykinin in vivo. Br. J. Pharmacol. 66:96P-97P.PubMedGoogle Scholar
  18. 18.
    Movat, H. Z. 1978. The kinin system: Its relation to blood coagulation, fibrinolysis and formed elements of the blood. Rev. Physiol. Biochem. Pharmacol. 84:143–202.PubMedCrossRefGoogle Scholar
  19. 19.
    Osmond, D. H., Lo, E. K., Loh, A. Y., Zingg, E. A., and Hedlin, A. H. 1978. Kallikrein and plasmin as activators of inactive renin. Lancet2:1375.CrossRefGoogle Scholar
  20. 20.
    Rocha e Silva, M., Beraldo, W., and Rosenfeld, G. 1949. Bradykinin, a hypotensive and smooth muscle stimulating factor releasing from plasma globulin by snake venom and by trypsin. Am. J. Physiol. 156:261–273.PubMedGoogle Scholar
  21. 21.
    Sealey, J. E., Altas, S. A., and Laragh, J. 1978. Linking the kallikrein and kinin system via activation of inactive renin. New data and hypothesis. Am. J. Med. 65:994–1000.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 1983

Authors and Affiliations

  • A. M. Chernukh
    • 1
  • O. A. Gomazkov
    • 1
  1. 1.Institute of General Pathology and Pathological PhysiologyAcademy of Medical Sciences of the USSRMoscowRussia

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