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Advances in Human Genetics pp 173–235Cite as

Linkage Analysis Using Somatic Cell Hybrids

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Part of the book series: Advances in Human Genetics ((AHUG,volume 3))

Abstract

It is my aim in this article to review current progress in somatic cell genetics. Somatic cell genetics, although a relatively new discipline, has already split into several different areas of investigation. For example, somatic cell hybrids are being used to study problems of cytodifferentiation,41 mitotic regulation,82,83,168,189 and activation of latent viruses.99,103,234 These subjects, while related to somatic cell genetics, will not directly concern us here. In this article, I shall focus on the utilization of somatic cell populations for the purpose of establishing the linkage relationships of genes to other genes and genes to chromosomes in higher eukaryotic organisms—especially man.

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  1. Department of Biology Kline Biology Tower, Yale University, New Haven, Connecticut, USA

    Frank H. Ruddle

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  1. The Galton Laboratory, University College London, London, England

    Harry Harris (Galton Professor of Human Genetics) (Galton Professor of Human Genetics)

  2. Division of Medical Genetics, Department of Pediatrics, Mount Sinai School of Medicine of The City University of New York, USA

    Kurt Hirschhorn (Arthur J. and Nellie Z. Cohen Professor of Genetics and Pediatrics) (Arthur J. and Nellie Z. Cohen Professor of Genetics and Pediatrics)

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Ruddle, F.H. (1972). Linkage Analysis Using Somatic Cell Hybrids. In: Harris, H., Hirschhorn, K. (eds) Advances in Human Genetics. Advances in Human Genetics, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4429-3_4

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  • DOI: https://doi.org/10.1007/978-1-4757-4429-3_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-4431-6

  • Online ISBN: 978-1-4757-4429-3

  • eBook Packages: Springer Book Archive

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