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Induced Chromosomal Aberrations in Man

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Advances in Human Genetics

Part of the book series: Advances in Human Genetics ((AHUG,volume 3))

Abstract

It has become increasingly clear in recent years that a multiplicity of chemical and physical agents to which man is exposed are capable of damaging his chromosomes. The effects of many such agents on human somatic cell chromosomes have now been well documented, albeit not without occasional controversy over the interpretation and implications of the data. While the biological and clinical significance of chromosomal aberrations are not as yet well understood, recent epidemiological evidence, from mutagen-exposed human populations, and recent experiments on viral-induced transformation of chromosomally abnormal cells suggest an association between chromosome aberrations and oncogenesis.

The recent original work of the author reported in this review was supported by grants from the National Institute of General Medical Sciences (NIH-I-PO1-GM-15419-04) and the U.S. Atomic Energy Commission (AT-11-1-1552). The studies at the Atomic Bomb Casualty Commission in Hiroshima and Nagasaki were supported by the U.S. Atomic Energy Commission and the Japanese National Institute of Health. The literature here selectively reviewed is through May 1971.

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  1. Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, USA

    Arthur D. Bloom

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  1. The Galton Laboratory, University College London, London, England

    Harry Harris (Galton Professor of Human Genetics) (Galton Professor of Human Genetics)

  2. Division of Medical Genetics, Department of Pediatrics, Mount Sinai School of Medicine of The City University of New York, USA

    Kurt Hirschhorn (Arthur J. and Nellie Z. Cohen Professor of Genetics and Pediatrics) (Arthur J. and Nellie Z. Cohen Professor of Genetics and Pediatrics)

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Bloom, A.D. (1972). Induced Chromosomal Aberrations in Man. In: Harris, H., Hirschhorn, K. (eds) Advances in Human Genetics. Advances in Human Genetics, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4429-3_3

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