Biomechanical Aspects of Tissue Growth and Engineering

  • Y. C. Fung
Part of the NATO ASI Series book series (NSSA, volume 235)


The historical development of the concept of stress modulated tissue remodeling is reviewed. Concrete new results are presented to show the following: 1) Morphological and structural remodeling of blood vessels due to change of blood pressure. 2) Remodeling of the zero-stress state of blood vessels as revealed by the change of the opening angles of the aorta due to hypertension. 3) Remodeling of mechanical properties as quantified by the change of material constants in the nonlinear constitutive equation. A unified interpretation of these remodeling processes is that a certain stress-growth law exists. I offer a simple mathematical stress-growth law for discussion.

Many of the papers presented in this book are concerned with cardiovascular prosthesis. These prosthesis when implanted into a patient must work with living tissues side by side. The prosthesis will not remodel, the living tissues will. Obviously the compatibility between the tissue and prosthesis should be engineered.


Pulmonary Artery Tissue Engineering Vessel Wall Opening Angle Blood Pressure Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Y. C. Fung
    • 1
  1. 1.Department of AMES — Bioengineering R-012University of California, San DiegoLa JollaUSA

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