Intercellular Collisions and Their Effect on Microcirculatory Transport

  • Harry L. Goldsmith
Part of the NATO ASI Series book series (NSSA, volume 235)


Shear-induced interactions between cells in flowing blood are involved in several important phenomena, such as the formation of aggregates, the dispersion of plasma and cells within vessels, the enhanced collision of cells with each other and the vessel wall, and changes in the distribution of cells within the vessels. This paper is concerned with an analysis of such interactions, particularly as they occur in small vessels. In order to better understand the phenomena, we begin by describing the simplest interaction, that of a two-body collision between spherical particles, and how fluid mechanical and colloid chemical theories applied to such collisions can be used to better understand interactions between red cells and between platelets. The effects of two-body collisions on particle trajectories are described, before proceeding to consider multi-body interactions in model suspensions and in blood, where the red cells exercise a considerable influence on platelet and white cell flow behavior.


Shear Rate High Shear Rate Poiseuille Flow Female Donor Whole Blood 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Harry L. Goldsmith
    • 1
  1. 1.McGill University Medical ClinicMontreal General HospitalMontrealCanada

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