New Concepts and Development of Vascular Graft Prostheses

  • Yasuharu Noishiki
Part of the NATO ASI Series book series (NSSA, volume 235)


There are several kinds of vascular graft prostheses, such as fabric Dacron prostheses, biological grafts, EPTFE grafts, cell seeding grafts, chemically treated connective tissue tube grafts, etc. They have been used safely in clinic, although with advantages and disadvantages. The biggest disadvantages are the poor healing ability of the neointima and lack of antithrombogenicity. Therefore, they cannot be used as venous and small diameter arterial grafts. For example, fabric Dacron prostheses have no natural antithrombogenicity. The surface is covered with fresh thrombi for a long period of time after implantation. Endothelialization of the grafts is limited to areas near the anastomotic sites. Conversely, EPTFE grafts have been expected to prevent thrombus formation. The grafts are hydrophobic and have less adhesive property. They can prevent the hydrophilic substances, but, hydrophobic substances can adhere to it followed by thrombi. Biological grafts are also not antithrombogenic and have a thrombus layer on the lumenal surface. If these grafts have an excellent healing ability of the neointima, they can maintain their patency for long periods of time with a powerful anticoagulant therapy just after implantation.


Vascular Graft Anastomotic Site External Iliac Artery Vascular Prosthesis Biological Graft 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Noishiki Y, Nagaoka S, Kikuchi T, Mori Y: Application of porous heparinized polymer to vascular graft, Trans. Am. Soc. Artif. Intern. Organs, 27: 213, 1981.PubMedGoogle Scholar
  2. 2.
    Noishiki Y, Miyata T: Successful animal study of small caliber heparin-protaminecollagen vascular grafts, Trans. Am. Soc. Artif. Intern. Organs, 31: 102, 1985.PubMedGoogle Scholar
  3. 3.
    Noishiki Y, Yamane Y, Satoh S, Niu S, Okoshi T, Tomizawa Y, Wildevuur CHR: Healing process of vascular prostheses seeded with venous tissue fragments, Trans. Am. Soc. Artif. Intern. Organs, 37: 478, 1991.Google Scholar
  4. 4.
    Noishiki Y, Watanabe K, Okamoto M, Kikuchi Y, Mori Y: Evaluation of a new vascular graft prosthesis fabricated from ultrafine polyester fiber, Trans. Am. Soc. Artif. Intern. Organs, 32: 309, 1986.Google Scholar
  5. 5.
    Tanzawa H, Mori Y, Miyama H, Hori M, Oshima N, Idezuki Y: Prevention and evaluation of a new a thrombogenic heparinized hydrophilic polymer for use in cardiovascular system, Trans. Am. Soc. Artif. Intern. Organs, 19: 188, 1973.PubMedCrossRefGoogle Scholar
  6. 6.
    Idezuki Y, Watanabe H, Hasegawa M, Kanasugi K, Mori Y, Nagaoka S, Hagio M, Yamamoto I, Tanzawa H: Mechanism of antithrombogenicity of a new heparinized hydrophilic polymer: Chronic in vivo studies and clinical application, Trans. Am. Soc. Artif. Intern. Organs, 21: 436, 1975.PubMedGoogle Scholar
  7. 7.
    Mori Y, Nagaoka S, Masubichi Y, Itoga M, Tanzawa H, Kikuchi Y, Yamada Y, Yonaha T, Watanabe H, Idezuki Y: The effect of released heparin from the heparinized hydrophilic polymer (H-RSD) on the process of thrombus formation, Trans. Am. Soc. Artif. Intern. Organs, 24: 736, 1978.PubMedGoogle Scholar
  8. 8.
    Mori Y, Nagaoka S, Itoga M, Tanzawa H, Yamada Y, Watanabe H, Idezuki Y: The effect of heparin release from a heparinized hydrophilic polymer (H-RSD) on antithrombogenicity, Trans. Am. Soc. Artif. Intern. Organs, 2 (Suppl): 66, 1978.Google Scholar
  9. 9.
    Noishiki Y, Miyata T, Kodaira K: Development of a small caliber vascular graft by a new crosslinking method incorporating slow heparin release collagen and natural tissue compliance, Trans. Am. Soc. Artif. Intern. Organs, 32: 114, 1986.Google Scholar
  10. 10.
    Noishiki Y, Miyata T: A simple method to heparinize materials, J. Biomed. Mat. Res., 20: 337, 1986.CrossRefGoogle Scholar
  11. 11.
    Wang CL, Miyata T, Weksler B, Stenzel KH: Collagen induced platelet aggregation and release, J. Biomchem. Biophys. Act., 544: 555, 1978.CrossRefGoogle Scholar
  12. 12.
    Hayashi K, Handa H, Nagasawa S, Okamura A, Moritake K: Stiffness and elastic behavior of human intracranial and extracranial arteries, J. Biomechanics, 13: 175, 1980.CrossRefGoogle Scholar
  13. 13.
    Miyata T, Noishiki Y, Matsumae M, Yamane Y: A new method to give an antithrombogenicity to biological materials and its successful application to vascular grafts, Trans. Am. Soc. Artif. Intern. Organs, 29: 363, 1983.PubMedGoogle Scholar
  14. 14.
    Noishiki Y: Pattern of arrangement of smooth muscle cells in neointima of synthetic vascular prostheses, J. Thorac. Cardiovasc. Surg., 75: 894, 1978.PubMedGoogle Scholar
  15. 15.
    Mori Y, Nagaoka S, Takiuchi H, Kikuchi N, Tanzawa H, Noishiki Y: A new antithrombogenic material with long polyethyleneoxide chains, Trans. Am. Soc. Artif. Intern. Organs, 28: 459, 1982.PubMedGoogle Scholar
  16. 16.
    Burger K, Sauvage LR, Rao AM, Wood SJ: Healing of arterial prostheses in man; its incompleteness, Ann. Surg., 175: 118, 1972.CrossRefGoogle Scholar
  17. 17.
    Herring MB, Gardner AL, Glover J: A single technique for seeding vascular graft with autologous endothélium, Surg., 84: 498, 1978.Google Scholar
  18. 18.
    Noishiki Y, Yamane Y, Tomizawa Y, Okoshi T, Satoh S, Wildevuur CHR: Endothelialization of vascular prostheses by transplantation of venous tissue fragments, Trans. Am. Soc. Artif. Intern. Organs, 36: 346, 1990.Google Scholar
  19. 19.
    Bell E, Ehrlich HP, Buttle DJ, Nakatsuji T: Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness, Science, 211: 1052, 1981.PubMedCrossRefGoogle Scholar
  20. 20.
    Wesolowski SA: Evaluation of tissue and prosthetic grafts, Charles C. Thomas Publisher, Spring Fields, 1962.Google Scholar
  21. 21.
    Wesolowski SA, Fries CC, Karlson ICE, DeBakey ME, Sayer PN: Polosity primary determinant of ultimate fate of synthetic vascular grafts, Surg., 50: 91, 1961.Google Scholar
  22. 22.
    Yates SG, Aires MS, Barros AB, Burger K, Fernandes LG, Wood SJ, Rittenhouse EA, Davis CC, Mansfield PB, Sauvage LF: The preclotting of porous arterial prostheses, Ann. Surg., 188: 611, 1978.PubMedCrossRefGoogle Scholar
  23. 23.
    Snooks SJ, Groft RJ, Chir CM, Wagner C: How should we preclot knitted Dacron graft ? J. Vasc. Surg., 7: 538, 1988.PubMedGoogle Scholar
  24. 24.
    Wuerflein RC, Campbell GS: Analysis of preclotting technique for prosthetic arterial grafts, Am. Surgeons, 29: 179, 1963.Google Scholar
  25. 25.
    Sauvage LR, Berger K, Wood SJ, Sameh AA, Wesolowski SA, Golaski WM, Dedomenico M, Hartmenn JR: A very thin, porous knitted arterial prosthesis: Experimental data and early clinical assessment, Surg., 65: 78, 1963.Google Scholar
  26. 26.
    Okamoto M: Ultra-fine fiber and its application, Preprints Japan-China Related Symposium on Polymer Science and Technology, 26 Tokyo, October 1981.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Yasuharu Noishiki
    • 1
  1. 1.First Department of SurgeryYokohama City University, School of MedicineYokohama, 236Japan

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