Design, Development and Testing of Blood Pumps

Part of the NATO ASI Series book series (NSSA, volume 235)


The term “blood pump” is very comprehensive. Practically, it describes all blood pumping devices from the roller pump to the artificial heart.


Centrifugal Pump Pulsatile Flow Blood Pump Artificial Heart Total Artificial Heart 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Nosé Y: The need for a nonpulsatile pumping system, Int. J. of Artificial Organs, 12 (2): 113–115, 1988.CrossRefGoogle Scholar
  2. 2.
    Senning A, Andres J, Bornstein P, Norberg B, Andersen NM: Renal function during extracorporeal circulation at high and low flow rates: experimental studies in dogs, Ann Surg., 151: 63, 1960.PubMedGoogle Scholar
  3. 3.
    Finsterbusch W: Renal arteriography during extracorporeal circulation in dogs, with preliminary report upon effects of low molecular weight Dextran, J. Thorac. Cardiovasc. Surg., 41: 252, 1961.Google Scholar
  4. 4.
    Kohlstaedt KG, Page IM: Liberation of renin by perfusion of kidneys following reduction of pulse pressure, J. Exp. Med., 71: 201, 1940.CrossRefGoogle Scholar
  5. 5.
    Agishi T, Peirce EC, Kent DB: A Comparison of pulsatile and nonpulsatile pumping for ex vivo renal perfusion, J. Surg. Res. 9: 623, 1969.PubMedCrossRefGoogle Scholar
  6. 6.
    Many M, Soroff HS, Birtwell WC, Giron F, Wise H, Deterling RA: The physiologic role of pulsatile and nonpulsatile blood flow. II. Effects on renal function, Arch. Surg., 95: 762, 1967.Google Scholar
  7. 7.
    Ogata T, Ida Y, Nonoyama A, Takeda J, Sasaki H: A comparative study on the effectiveness of pulsatile and nonpulsatile blood flow in extracorporeal circulation, Arch. Jpn. Chir., 29: 59, 1969.Google Scholar
  8. 8.
    Long D (Discussion of Sanger PW et al.): Vasomotor regulation during extracorporeal circulation and open-heart surgery, J. Thorac. Cardiovasc. Surg., 1:355, 1960.Google Scholar
  9. 9.
    Petrow JM: Theorie der Mikrozirkulation. Teil 3: Die Rolle der Blutdruckamplitude bei der Mikrozirkulation im Gewebe, Zeitschrift für die gesamte Innere Medizin, 45 (21): 633–638, 1990.Google Scholar
  10. 10.
    Parsons RJ, MacMasters PD: Effects of pulse upon formation and flow of lymph, J. Exper. Med., 68: 353, 1938.CrossRefGoogle Scholar
  11. 11.
    Wilkens H, Regelson W, Hoffmeister FS: The physiologic importance of pulsatile blood flow, N. Engl. J. Med., 267: 443, 1962.PubMedCrossRefGoogle Scholar
  12. 12.
    Shepard RB, Kirklin JW: Relation of pulsatile flow to oxygen consumption and other variables during cardiopulmonary bypass, J. Thorac. Cardiovasc. Surg., 58: 694, 1969.PubMedGoogle Scholar
  13. 13.
    Sanderson JM, Wright G, Sims FW: Brain damage in dogs immediately following pulsatile and nonpulsatile blood flow in extracorporeal circulation, Thorax., 27: 275, 1972.PubMedCrossRefGoogle Scholar
  14. 14.
    Wright G, Sanderson JM: Brain damage and mortality in dogs following pulsatile and nonpulsatile blood flow in extracorporeal circulation, Thorax., 27: 738, 1972.PubMedCrossRefGoogle Scholar
  15. 15.
    Mandelbaum J, Burns WH: Pulsatile and nonpulsatile blood flow, JAMA 1918, 121, 1965.Google Scholar
  16. 16.
    Trinkle JK, Helton NE, Bryant LR, Griffen WO: Pulsatile cardiopulmonary bypass: Clinical evaluation, Surgery, 68: 1074, 1970.PubMedGoogle Scholar
  17. 17.
    Soroff HS, Many M, Birtwell WC, Giron F, Deterling RA: Hemodynamic effects of pulsatile and non pulsatile blood flow, Arch. Surg., 98: 321, 1969.Google Scholar
  18. 18.
    Guyton AC: Textbook of Medical Physiology, W.B. Sanders, Co., Philadelphia, London, Toronto, 1971.Google Scholar
  19. 19.
    Rushmer RF: Cardiovascular dynamics, Saunder Philadelphia, 1970.Google Scholar
  20. 20.
    Myers GH, Parsonnet V: Blood pressure regulation (Chapt. 3), In: Engineering in the heart and blood vessels (Eds., Myers, Parsonnet ), Wiley Interscience Publ., New York, 1969.Google Scholar
  21. 21.
    Rokitansky A, Wolner E: Total artificial heart and assist devices as a bridge to transplant, Intern. J. of Artificial Organs, 2: 77–84, 1989.Google Scholar
  22. 22.
    Unger F: Assisted Circulation I, II, III, Springer Verlag Berlin, Heidelberg, New York 1979, 1984, 1989.Google Scholar
  23. 23.
    Knierbein B, Rosarius N, Reul H, Rau G: New methods for the development of pneumatic displacement pumps for cardiac assist, Intern. J. of Artificial Organs, 13 (11): 751–759, 1990.Google Scholar
  24. 24.
    Arabia M, Akutsu T: A new test circulatory system for research in cardiovascular engineering, Annals of Biomedical Engineering, Pergamon Press Ltd., 12, 29–48, 1984.Google Scholar
  25. Donavan FM: Design of a hydraulic analog of the circulatory system for evaluation of artificial hearts, Medical Devices and Artif. Org., 3(4):439–49, 1975.Google Scholar
  26. 26.
    Kolff WJ: Mock circulation to test pumps designed for permanent replacement of damaged hearts, Cleveland Clin. Quart., 26: 223–227, 1959.Google Scholar
  27. 27.
    Reul H, Runge JA: A hydraulic analog of the systemic and pulmonary circulation for testing artificial hearts, preliminary report, Proceedings ESAO I, 159–162, 1974.Google Scholar
  28. 28.
    Reul H, Runge JA: A hydraulic analog of the systemic and pulmonary circulation for testing artificial hearts, progress report, Proceedings ESAO II, 120–127, 1975.Google Scholar
  29. 29.
    Rosenberg G, Phillips WM, Landis DL, Pierce WS: Design and evaluation of the Pennsylvania State University mock circulatory system, ASAIO J., 4: 41–49, 1981.Google Scholar
  30. 30.
    Swanson WM, Clark RE: A simple cardiovascular system simulator: design and performance, J. of Bioengineering, 1: 135–145, 1977.Google Scholar
  31. 31.
    Wallner F: Development of a circulation mock up, Langenbecks Arch. Chir. 335 by Springer Verlag, 65, 1974.Google Scholar
  32. 32.
    Knierbein B, Reul H, Eilers R, Lange M, Kaufmann R, Rau G: Compact mock loops of the systemic and pulmonary circulation for blood pump testing, Intern. J. of Artificial Organs, 15 (1): 40–48, 1992.Google Scholar
  33. 33.
    Westphal D, Reul H, Rau G: Development and in vitro test results of the Helmholtz Centrifugal Pump, Proceedings of the Int. Workshop on Rotary Blood Pumps, Baden/Vienna Austria, Sept. 1991.Google Scholar
  34. 34.
    Westphal D, Rasche A, Reul H, Rau G: Blood damage in blood pumps: theoretical background and experimental results, Proceedings of the BME Workshop on in vitro testing of blood pumps, Aachen, April 1991 (in press).Google Scholar
  35. 35.
    FDA: Guidance for the preparation of applications to the FDA for ventricular assist devices and total artificial hearts, Silver Spring, Maryland, Dec. 3, 1987.Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • H. Reul
    • 1
  1. 1.Helmholtz-Institute for Biomedical Engineering at the RWTH AachenAachenGermany

Personalised recommendations