Ex Vivo Models for Studying Thrombosis: Special Emphasis on Shear Rate Dependent Blood-Collagen Interactions

  • Kjell S. Sakariassen
  • Helge E. Roald
  • José Aznar Salatti
Part of the NATO ASI Series book series (NSSA, volume 235)


Perfusion models that allow exposure of artery subendothelium, collagen and other surfaces to non-anticoagulated blood (ex vivo models) or to anticoagulated blood (in vitro models) under well controlled experimental conditions have given much useful information about thrombotic mechanisms(1–15) This includes a better understanding of molecular mechanisms of platelet-surface adhesion(3,6,13,16–19), platelet-platelet interactioe(3,13,16,20–23), and the interplay between coagulation and platelet function in thrombus formation(4,12–14,22–27) However, the blood flow, and in particular the shear rate, plays an unambiguous role in these events(1–3,13,14,16.17,19,21–25,28,29).


Shear Rate Collagen Fibril Platelet Adhesion Blood Flow Rate Wall Shear Rate 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Kjell S. Sakariassen
    • 1
  • Helge E. Roald
    • 1
  • José Aznar Salatti
    • 1
  1. 1.Biotechnology Centre of OsloUniversity of OsloOsloNorway

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