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Basic Proteins of Central and Peripheral Nervous System Myelin

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Advances in Neurochemistry

Abstract

Studies on the ultrastructure and physiological function of myelin have generally been with peripheral nervous system (PNS) tissue, while chemical studies on the composition of myelin have more often used central nervous system (CNS) tissue. In addition, because of immunological studies on multiple sclerosis, there has been a rapid growth in knowledge of some of the proteins of CNS myelin.

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References

  • Adams, C. W. M., Bayliss, O. B., Hallpike, J. F., and Turner, D. R., 1971, Histochemistry of myelin, XII, anionic staining of myelin basic proteins for histology, electrophoresis and electron microscopy, J. Neurochem. 18: 389–394.

    Article  PubMed  CAS  Google Scholar 

  • Adams, C. W. M., 1972, in Research on Multiple Sclerosis (C. W. M. Adams and U. Leibowitz, eds.), pp. 19–60, Charles C. Thomas, Illinois.

    Google Scholar 

  • Adams, D. H., and Osborne, J., 1973, A developmental study of the relationship between the protein components of rat CNS myelin, Neurobiology 3: 91–112.

    PubMed  CAS  Google Scholar 

  • Agrawal, H. C, Banik, N. L., Bone, A. H., Davison, A. N., Mitchell, R. F., and Spohn, M., 1970, The identity of a myelin-like fraction isolated from developing brain, Biochem. 7.120: 635–642.

    Google Scholar 

  • Agrawal, H. C, Banik, N. L., Bone, A. H., Cuzner, M. L., Davison, A. N., and Mitchell, R. F., 1971, The chemical composition of dogfish myelin, Biochem. J. 124: 70P.

    Google Scholar 

  • Agrawal, H. C, Burton, R. M., Fishman, M. A., Mitchell, R. F., and Prensky, A. L., 1972, Partial characterization of a new myelin protein component, J. Neurochem. 19: 2083–2089.

    Article  PubMed  CAS  Google Scholar 

  • Agrawal, H. C, Trotter, J. L., Mitchell, R. F., and Burton, R. M., 1973, Criteria for identifying a myelin-like fraction from developing brain, Biochem. J. 136: 1117–1119.

    PubMed  CAS  Google Scholar 

  • Alvord, E. C, Jr., 1970, Acute disseminating encepholomyelitis and “allergic” neuro-encephal-opathies, in Handbook of Clinical Neurology (P. J. Viken and G. W. Bruyn, eds.), Vol. 9, pp. 500–571, North-Holland Publ. Co., Amsterdam.

    Google Scholar 

  • Anthony, J. S., and Moscarello, M. A., 1971, A conformation change induced in the basic encephalitogen by lipids, Biochim. Biophys. Acta 243: 429–433.

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, G. S., and Carnegie, P. R., 1971a, Specific enzymic methylation of an arginine in the experimental allergic encephalomyelitis protein from human myelin, Science 171: 579–581.

    Article  PubMed  CAS  Google Scholar 

  • Baldwin, G. S., and Carnegie, P. R., 1971b, Isolation and partial characterization of methylated arginines from the encephalitogenic basic protein of myelin, Biochem. J. 123: 69–74.

    PubMed  CAS  Google Scholar 

  • Banik, N. L., and Davison, A. N., 1969, Enzyme activity and composition of myelin and subcellular fractions in the developing rat brain, Biochem. J. 115: 1051–1062.

    PubMed  CAS  Google Scholar 

  • Banik, N. L., and Davison, A. N., 1973, Isolation of purified basic protein from human brain, J. Neurochem. 21: 489–494.

    Article  PubMed  CAS  Google Scholar 

  • Bear, R. S., 1971, The structure of the myelin sheath, Neurosciences Res. Prog. Bull. 9: 507–598.

    CAS  Google Scholar 

  • Bencina, B., Carnegie, P. R., McPherson, T. A., and Robson, G., 1969, Encephalitogenic basic protein from sciatic nerve, FEBS Letters 4: 9–12.

    Article  PubMed  CAS  Google Scholar 

  • Bergstrand, H., 1971, Isolation and partial characterization of some proteolytically and chemically derived fragments of bovine encephalitogenic protein, Eur. J. Biochem. 21: 116–124.

    Article  PubMed  CAS  Google Scholar 

  • Bergstrand, H., 1972, Encephalitogenic activity in rabbits of the C-terminal region of bovine basic myelin protein: Localization to two different regions, FEBS Letters 23: 195–198.

    Article  PubMed  CAS  Google Scholar 

  • Bergstrand, H., and Kallen, B., 1973a, Is there a cross-reactivity between different parts of the bovine encephalitogenic protein in the macrophage migration inhibition assay? Immunochemistry 10: 471 – 476.

    Article  PubMed  CAS  Google Scholar 

  • Bergstrand, H., and Kallen, B., 19736, Antigenic determinants on bovine encephalitogenic protein: Studies in rabbits with derivatives of fragment 1–43 and the lymph node cell transformation test, Neurobiology 3: 246–255.

    PubMed  CAS  Google Scholar 

  • Block, R. E., Brady, A. H., and Joffe, S., 1973, Conformation and aggregation of bovine myelin proteins, Biochem. Biophys. Res. Commun. 54: 1595–1602.

    Article  PubMed  CAS  Google Scholar 

  • Braun, P. E., and Barchi, R. L., 1972, 2’, 3’-Cyclic nucleotide 3’-phosphodiesterase in the nervous system: Electrophoretic properties and developmental studies, Brain Res. 40: 437 – 444.

    Article  PubMed  CAS  Google Scholar 

  • Brostoff, S., and Eylar, E. H., 1971, Localization of methylated arginine in the A1 protein from myelin, Proc. Nat. Acad. Sci. (U.S.A.) 68: 765–769.

    Article  CAS  Google Scholar 

  • Brostoff, S. W., and Eylar, E. H., 1972, The proposed amino acid sequence of the P1 protein of rabbit sciatic nerve myelin, Arch. Biochem. Biophys. 153: 590–598.

    Article  PubMed  CAS  Google Scholar 

  • Brostoff, S., Burnett, P., Lampert, P., and Eylar, E. H., 1972, Isolation and characterization of a protein from sciatic nerve myelin responsible for experimental allergic neuritis, Nature (New Biol.) 235: 210–212.

    CAS  Google Scholar 

  • Brostoff, S. W., Wisneiwski, H. M., Greenfield, S., Morell, P., and Eylar, E. H., 1973, Immunopathologic response in guinea pigs sensitized with peripheral nervous system myelin, Brain. Res. 58: 500–505.

    Article  PubMed  CAS  Google Scholar 

  • Brostoff, S. W., Reuter, W., Hichens, M., and Eylar, E. H., 1974, Specific cleavage of the Al protein from myelin with cathepsin D, J. Biol. Chem. 249: 559–567.

    PubMed  CAS  Google Scholar 

  • Bunge, R. P., 1968, Glial cells and the central myelin sheath, Physiological Reviews 48: 197–251.

    PubMed  CAS  Google Scholar 

  • Burnett, P. R., and Eylar, E. H., 1971, Allergic encephalomyelitis. Oxidation and cleavage of the single tryptophan residue of the A! protein from bovine and human myelin, J. Biol..Chem. 246: 3425–3430.

    Google Scholar 

  • Carnegie, P. R., 1969, N-terminal sequence of an encephalitogenic protein from human myelin, Biochem. J. 111 : 240–242.

    PubMed  CAS  Google Scholar 

  • Carnegie, P. R., 1971a, Amino acid sequence of the encephalitogenic basic protein of human myelin, Biochem. J. 123: 57–67.

    PubMed  CAS  Google Scholar 

  • Carnegie, P. R., 19716, Properties, structure and possible neuroreceptor role of the encephalitogenic protein of human brain, Nature (London) 229: 25–28.

    Article  CAS  Google Scholar 

  • Carnegie, P. R., 1974, Interaction of 5-hydroxytryptamine with the encephalitogenic protein of myelin, in Neurosciences Third Study Program (F. O. Schmitt and G. Wordin, eds.), pp. 925–928, MIT Press, Cambridge.

    Google Scholar 

  • Carnegie, P. R., and Sims, N. R., 1975, Properties of myelin proteins and enzymes and their possible role in multiple sclerosis, in Current Studies in Multiple Sclerosis (E. J. Field, ed.), Medical and Technical Publishing Co., Oxford, England, in preparation.

    Google Scholar 

  • Carnegie, P. R., Bencina, B., and Lamoureux, G., 1967, Experimental allergic encephalomyelitis, Biochem. 7.105: 559–568.

    Google Scholar 

  • Carnegie, P. R., Symthies, J. R., Caspary, E. A., and Field, E. J., 1972, Interaction of hallucinogenic drugs with encephalitogenic protein of myelin, Nature (London) 240: 561–563.

    Article  CAS  Google Scholar 

  • Carnegie, P. R., Kemp, B. E., Dunkley, P. R., and Murray, A. W., 1973, Phosphorylation of myelin basic protein by a cyclic AMP-dependent protein kinase, Biochem. J. 135: 589–591.

    Google Scholar 

  • Carnegie, P. R., Dunkley, P. R., Kemp, B. E., and Murray, A. W., 1974, Phosphorylation of selected serine and threonine residues in myelin basic protein by endogenous and exogenous protein kinases, Nature (London) 249: 147–150.

    Article  CAS  Google Scholar 

  • Caspary, E. A., and Field, E. J., 1965, An encephalitogenic protein of human origin: some chemical and biological properties, Ann. N.Y. Acad. Sci. 122: 182–198.

    Article  PubMed  CAS  Google Scholar 

  • Chao, L. P., and Einstein, E. R., 1969, Estimation of molecular weight of flexible disordered proteins by exclusion chromatography, J. Chromatography 42: 485–492.

    Article  CAS  Google Scholar 

  • Chao, L. P., and Einstein, E. R., 1970, Physical properties of the encephalitogenic protein: Molecular weight and conformation, J. Neurochem. 17: 1121–1132.

    Article  PubMed  CAS  Google Scholar 

  • Csejtey, J., Hallpike, J. F., Adams, C. W. M., and Bayliss, O. B., 1972, Histochemistry of myelin. XIV. Peripheral nerve myelin proteins: Electrophoretic and histochemical correlations, J. Neurochem. 19: 1931–1935.

    Article  PubMed  CAS  Google Scholar 

  • Daile, P., and Carnegie, P. R., 1975, Sites of phosphorylation by cyclic AMP-dependent protein kinases, in preparation.

    Google Scholar 

  • Davison, A. N., 1961, Metabolically inert proteins of the central and peripheral nervous system, muscle, and tendon, Biochem. J. 78: 272–282.

    PubMed  CAS  Google Scholar 

  • Davison, A. N., 1970, The biochemistry of the myelin sheath, in Myelination (A. N. Davison and A. Peters, eds.), pp. 80–161, Charles C. Thomas, Illinois.

    Google Scholar 

  • Davison, A. N., 1971, The biochemistry of myelinogenesis in the central nervous system, in Chemistry and Brain Development (R. Paoletti and A. N. Davison, eds.), pp. 375–380, Plenum Press, New York.

    Chapter  Google Scholar 

  • Dayhoff, M. D., 1972, in Atlas of Protein Sequence and Structure, Vol. 5, National Biochemical Research Foundation, Silver Spring, Md.

    Google Scholar 

  • Deibler, G. E., and Martenson, R. E., 1973a, Chromatographic fractionation of myelin basic protein: Partial characterization and methylarginine contents of the multiple forms, J. Biol. Chem. 248: 2392–2396.

    PubMed  CAS  Google Scholar 

  • Deibler, G. E., and Martenson, R. E., 19736, Determination of methylated basic amino acids with the amino acid analyser: Application to total acid hydrolysates of myelin basic proteins, J. Biol. Chem. 248: 2387–2391.

    PubMed  CAS  Google Scholar 

  • Deibler, G. E., Martenson, R. E., and Kies, M. W., 1970, Gel filtration of proteins at acid pH application to molecular weight estimation of myelin basic proteins, Biochim. Biophys. Acta 200: 342–352.

    Article  PubMed  CAS  Google Scholar 

  • Deibler, G. E., Martenson, R. E., and Kies, M. W., 1972, Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species, Prep. Biochem. 2: 139–165.

    Article  PubMed  CAS  Google Scholar 

  • Demel, R. A., London, Y., Geurts Van Kessel, W. S., Vossenberg, F. G., and Deenen, L. L. Van, 1973, The specific interaction of myelin basic protein with lipids at the air-water interface, Biochim. Biophys. Acta 311: 507–519.

    Article  PubMed  CAS  Google Scholar 

  • Dickinson, J. P., Jones, K. M., Aparicio, S. R., and Lumsden, C. E., 1970, Localization of encephalitogenic basic protein in the intraperiod line of lamellar myelin, Nature (London) 227: 1133–1134.

    Article  CAS  Google Scholar 

  • D’Monte, B., Mela, P., and Marks, N., 1971, Metabolic instability of myelin protein and proteo- lipid fractions, Eur. J. Biochem. 23: 355–365.

    Article  PubMed  Google Scholar 

  • Driscoll, B. F., Kramer, A. J., and Kies, M. W., 1974, Myelin basic protein: location of multiple independent antigenic regions, Science 184: 73–75.

    Article  PubMed  CAS  Google Scholar 

  • Dunkley, P. R., and Carnegie, P. R., 1974a, Isolation of myelin basic proteins, in Research Methods in Neurochemistry (N. Marks and R. Rodnight, eds.), Vol. 2, pp. 219–245, Plenum Press, New York.

    Chapter  Google Scholar 

  • Dunkley, P. R., and Carnegie, P. R., 1974b, Sequence of a rat myelin basic protein, Biochem. 7.141: 243–255.

    CAS  Google Scholar 

  • Dunkley, P. R., Coates, A. S., and Carnegie, P. R., 1973, Encephalitogenic activity of peptides from the smaller basic protein of rat brain myelin, J. Immunol. 110: 1699–1701.

    PubMed  CAS  Google Scholar 

  • Einstein, E. R., 1972, Basic protein of myelin and its role in experimental allergic encephalomyel itis and multiple sclerosis, Handbook of Neurochemistry 7: 107–129.

    Article  CAS  Google Scholar 

  • Einstein, E. R., 1974, Protein and enzyme changes with brain development, in Drugs and the Developing Brain (A. Vernadakis and N. Weiner, eds.), pp. 375–393, Plenum Press, New York.

    Chapter  Google Scholar 

  • Einstein, E. R., Csejtey, J., Davis, W., and Rauch, M., 1965, Studies on encephalitogenic protein of human brain origin, Proc. 8th Int. Cong. Neurol. 4: 137–153.

    Google Scholar 

  • Einstein, E. R., Csejtey, J., and Marks, N., 1968, Degradation of encephalitogen by purified brain acid proteinase, FEBS Letters 1: 191–195.

    Article  PubMed  Google Scholar 

  • Einstein, E. R., Dalai, K. B., and Csejtey, J., 1970, Biochemical maturation of the central nervous system. II. Protein and proteolytic enzyme changes, Brain Res. 18: 35–49.

    Article  PubMed  CAS  Google Scholar 

  • Einstein, E. R., Csejtey, J., Dalai, K. B., Adams, C. W. M., Bayliss, O. B., and Hallpike, J. F., 1972, Proteolytic activity and basic protein loss in and around multiple sclerosis plaques: Combined biochemical and histochemical observations, J. Neurochem. 19: 653–662.

    Article  PubMed  CAS  Google Scholar 

  • Eng, L. F., Chao, F. C, Gerstl, B., Pratt, D., and Tavaststjerna, M. G., 1968, The Maturation of human white matter myelin: Fractionation of the myelin membrane proteins, Bio chemistry 7: 4455–4465.

    CAS  Google Scholar 

  • Epand, R. M., Moscarello, M. A., Zierenberg, B., and Vail, W. J., 1974, The folded conformation of the encephalitogenic protein of human brain, Biochemistry 13: 1264–1267.

    Article  PubMed  CAS  Google Scholar 

  • Everly, J. L., Brady, R. O., and Quarles, R. H., 1973, Evidence that the major protein in rat sciatic nerve myelin is a glycoprotein, J. Neurochem. 21: 329–334.

    Article  PubMed  CAS  Google Scholar 

  • Eylar, E. H., 1970, Amino acid sequence of the basic protein of myelin membrane, Proc. Nat. Acad. Sci. (U.S.A.) 67: 1425–1431.

    Article  CAS  Google Scholar 

  • Eylar, E. H., 1972, The structure and immunologic properties of basic proteins of myelin, Ann. N.Y. Acad. Sci. 195: 481–491.

    Article  PubMed  CAS  Google Scholar 

  • Eylar, E. H., 1973, Myelin-specific proteins, in Proteins of the Nervous System (D. J. Schneider, R. H. Angeletti, R. A. Bradshaw, A. Grasso, and B. W. Moore, eds.), pp. 27–44, Raven Press, New York.

    Google Scholar 

  • Eylar, E. H., and Thompson, M., 1969, Allergic encephalomyelitis: The physicochemical properties of the basic protein encephalitogen from bovine spinal cord, Arch. Biochem. Biophys. 129: 468–479.

    Article  PubMed  CAS  Google Scholar 

  • Eylar, E. H., Salk, J., Beveridge, G. C, and Brown, L. V., 1969, Experimental allergic encephalomyelitis: An encephalitogenic basic protein from bovine myelin, Arch. Biochem. Biophys. 132: 34–48.

    Article  PubMed  CAS  Google Scholar 

  • Eylar, E. H., Brostoff, S., Hashim, G., Caccam, J., and Burnett, P., 1971, Basic A1 protein of the myelin membrane: The complete amino acid sequence, J. Biol. Chem. 246: 5770–5784.

    PubMed  CAS  Google Scholar 

  • Eylar, E. H., Brostoff, S., Jackson, J., and Carter, H., 1972, Allergic encephalomyelitis in monkeys induced by a peptide from the Al protein. Proc. Nat. Acad. Sci. (U.S.A.) 69: 617 – 619.

    Article  CAS  Google Scholar 

  • Finch, P. R., and Moscarello, M. A., 1972, A myelin protein fraction extracted with thioethanol, Brain Res. 42: 177–187.

    Article  PubMed  CAS  Google Scholar 

  • Fischer, C. A., and Morell, P., 1974a, Turnover of proteins in myelin and myelin-like material of mouse brain, Brain Res. 74: 51–65.

    Article  PubMed  CAS  Google Scholar 

  • Fischer, C. A., and Morell, P., 19746, Precursor dependent turnover measures of proteins in myelin and myelin-like material during development, Society for Neuroscience (Abstract).

    Google Scholar 

  • Folch-Pi, J., 1972, Proteolipids, in Functional and Structural Proteins of the Nervous System (A. N. Davison, P. Mandel, and I. G. Morgan, eds.), pp. 171–199, Plenum Press, New York.

    Chapter  Google Scholar 

  • Gaitonde, M. K., and Martenson, R. E., 1970, Metabolism of highly basic proteins of rat brain during postnatal development, J. Neurochem. 17: 551–563.

    Article  PubMed  CAS  Google Scholar 

  • Giorgi, P. P., Karlsson, J. O., Sjostrand, J., and Field, E. J., 1973, Axonal flow and myelin protein in the optic pathway, Nature (London) 244: 121–124.

    CAS  Google Scholar 

  • Gonzalez-Sastre, F., 1970, The protein composition of isolated myelin, J. Neurochem. 17: 1049 – 1056.

    Article  PubMed  CAS  Google Scholar 

  • Gould, R. M., and London, Y., 1972, Specific interaction of central nervous system myelin basic protein with lipids: Effects of basic protein on glucose leakage from liposomes, Biochim. Biophys. Acta 290: 200–218.

    Article  PubMed  CAS  Google Scholar 

  • Greenfield, S., Norton, W. T., and Morell, P., 1971, Quaking mouse: Isolation and characterization of myelin protein, J. Neurochem. 18: 2119–2128.

    Article  PubMed  CAS  Google Scholar 

  • Greenfield, S., Brostoff, S., Eylar, E. H., and Morell, P., 1973, Protein composition of myelin of the peripheral nervous system, J. Neurochem. 20: 1207–1216.

    Article  PubMed  CAS  Google Scholar 

  • Hagopian, A., and Eylar, E. H., 1968, Glycoprotein biosynthesis: Studies on the receptor specificity of the polypeptidyl N-acetylgalactosaminyl transferase from bovine submaxillary glands, Arch. Biochem. Biophys. 128: 422–433.

    Article  PubMed  CAS  Google Scholar 

  • Hagopian, A., Westall, F. C, Whitehead, J. S., and Eylar, E. H., 1971, Glycosylation of the Al protein from myelin by a polypeptide N-acetylgalactosaminyl transferase: Identification of the receptor sequence, J. Biol. Chem. 246: 2519–2523.

    PubMed  CAS  Google Scholar 

  • Hashim, G. A., and Eylar, E. H., 1969a, Allergic encephalomyelitis: Isolation and characterization of encephalitogenic peptides from the basic protein of bovine spinal cord, Arch. Biochem. Biophys. 129: 645–654.

    Article  PubMed  CAS  Google Scholar 

  • Hashim, G. A., and Eylar, E. H., 19696, The structure of the terminal regions of the encephalitogenic A1 protein, Biochem. Biophys. Res. Comm. 34: 770–776.

    Article  PubMed  CAS  Google Scholar 

  • Hashim, G. A., Hwang, F., and Schilling, F. J., 1973, Experimental allergic encephalomyelitis: Basic protein regions responsible for delayed hypersensitivity, Arch. Biochem. Biophys. 156: 298–309.

    Article  PubMed  CAS  Google Scholar 

  • Hergstrand, L. R., and Kornguth, S. E., 1973, Isolation and partial characterization of the myelin basic protein from foetal calf brains, Biochim. Biophys. Acta 317: 380–393.

    Article  Google Scholar 

  • Herndon, R. M., Rauch, H. C, and Einstein, E. R., 1973, Immuno-electron microscopic localization of the encephalitogenic basic protein in myelin, Immunol. Commun. 2: 163 – 172.

    PubMed  CAS  Google Scholar 

  • Hulcher, F., Spudis, E., and Netsky, M. G., 1963, Encephalomyelitis induced by the white matter fraction, Arch. Neurol. (Chic.) 8: 1–7.

    Article  CAS  Google Scholar 

  • Jones, G., and Carnegie, P. R., 1974, Methylation of myelin basic protein by enzymes from rat brain, J. Neurochem. 23: 1231–1237.

    Article  PubMed  CAS  Google Scholar 

  • Kabat, E. A., Wolf, A., and Bozer, A. E., 1947, The rapid production of acute disseminated encephalomyelitis in rhesus monkeys by injection of heterogeneous and homologous brain tissue with adjuvants, J. Exptl. Med. 85: 117–131.

    Article  CAS  Google Scholar 

  • Kibler, R. F., Fox, R. H., and Shapira, R., 1964, Isolation of a highly purified encephalitogenic protein from bovine cord, Nature (London) 204: 1273–1275.

    Article  CAS  Google Scholar 

  • Kibler, R. F., Re, P. K., McKneally, S., and Shapira, R., 1972, Biological activity of an encephalitogenic fragment in the monkey, J. Biol. Chem. 247: 969–972.

    PubMed  CAS  Google Scholar 

  • Kies, M. W., 1965, Chemical studies on an encephalitogenic protein from guinea pig brain, Ann. N.Y. Acad. Sci. 122: 161–170.

    Article  CAS  Google Scholar 

  • Kies, M. W., 1973, Experimental allergic encephalomyelitis, in Biology of Brain Dysfunction (G. E. Gaul, ed.), Vol. II, pp. 185–224, Plenum Press, New York.

    Chapter  Google Scholar 

  • Kies, M. W., and Alvord, E. C, Jr., 1959, Encephalitogenic activity in guinea pigs of water soluble protein fractions of nervous tissue, in Allergic Encephalomyelitis (M. W. Kies, and E. C. Alvord, Jr., eds.), pp. 293–299, Charles C. Thomas, Illinois.

    Google Scholar 

  • Kies, M. W., Gordon, S., Laatsch, R. H., and Alvord, E. C., Jr., 1961, Cellular localization of allergic encephalomyelitic activity in guinea pig brain, in Proceedings International Congress of Neuropathology (H. Jacob, ed.), pp. 20–29, Georg Thieme Verlag, Stuttgart.

    Google Scholar 

  • Kies, M. W., Thompson, E. B., and Alvord, E. C, Jr., 1965, The relationship of myelin proteins to experimental allergic encephalomyelitis, Ann. N.Y. Acad. Sci. 122: 148–160.

    Article  PubMed  CAS  Google Scholar 

  • Ko, G. K. W., and Raghupathy, E., 1972, Glycoprotein biosynthesis in the developing rat brain. II. Microsomal galactosaminyl transferase utilizing endogenous and exogenous protein acceptors, Biochim. Biophys. Acta 264: 129–143.

    Article  PubMed  CAS  Google Scholar 

  • Kornguth, S. E., and Perrin, J. H., 1971, Circular dichroism and viscometric studies on a basic protein from pig brain, J. Neurochem. 18: 983–988.

    Article  PubMed  CAS  Google Scholar 

  • Kornguth, S. E., Kozel, L. R., and Smithies, O., 1972, Tissue specific histone, probable identity with encephalitogenic protein, Nature (New Biol.) 237: 49–50.

    Article  CAS  Google Scholar 

  • Krigbaum, W. R., and Knutton, S. P., 1973, Prediction of the amount of secondary structure in a globular protein from its amino acid composition, Proc. Nat. Acad. Sci. (U.S.A.) 70: 2809 – 2813.

    Article  CAS  Google Scholar 

  • Laatsch, R. H., Kies, M. W., Gordon, S., and Alvord, E. C, Jr., 1962, The encephalitogenic activity of myelin isolates by ultracentrifugation, J. Exptl. Med. 115: 777–788.

    Article  CAS  Google Scholar 

  • Lajtha, A., and Marks, N., 1971, Protein turnover, Handbook of Neurochemistry 5B: 551–630.

    Google Scholar 

  • Leach, S. J., and Smith, J. A., 1972, Thermal perturbation difference spectroscopy of proteins, Int. J. Protein Research, 4: 11–19.

    Article  CAS  Google Scholar 

  • Lennon, V. A., 1972, Cellular and humoral immune responses in experimental autoimmune encephalomyelitis, Ph.D. Thesis, Melbourne University.

    Google Scholar 

  • Lennon, V. A., Wilks, A. V., and Carnegie, P. R., 1970, Immunologic properties of the main encephalitogenic peptide from the basic protein of human myelin, J. Immunol. 10: 1223–1230.

    Google Scholar 

  • Lim, L., White, J. O., Hall, C, Berthold, W., and Davison, A. N., 1974, Isolation of microsomal poly(A)-RNA from rat brain directing the synthesis of the myelin encephalitogenic protein in Xenopus oocytes, Biochim. Biophys. Acta 361: 241–247.

    Article  PubMed  CAS  Google Scholar 

  • London, Y., 1971, Ox peripheral nerve myelin membrane: Purification and partial characterization of two basic proteins, Biochim. Biophys. Acta 249: 188–196.

    Article  PubMed  CAS  Google Scholar 

  • London, Y., 1972, Preparation of purified myelin from ox intradural spinal roots by rateisopyenic zonal centrifugation, Biochim. Biophys. Acta 282: 195–204.

    Article  PubMed  CAS  Google Scholar 

  • London, Y., and Vossenberg, F. G. A., 1973, Specific interaction of central nervous system myelin basic protein with lipids: Specific regions of the protein sequence protected from proteolytic action of trypsin, Biochim. Biophys. Acta 307: 478–490.

    Article  PubMed  CAS  Google Scholar 

  • London, Y., Demel, R. A., Geurts Van Kessel, W. S., Vossenberg, F. G., and Deenen, L. L. Van, 1973, The protection of A1 myelin basic protein against the action of proteolytic enzymes after interaction of the protein with lipids at the air-water interface, Biochim. Biophys. Acta 311: 520–530.

    Article  PubMed  CAS  Google Scholar 

  • London, Y., Demel, R. A., Geurts Van Kessel, W. S., Zahler, P., and Deenen, L. L. Van, 1974, The interaction of the “Folch-Lees” protein with lipids at the air-water interface, Biochim. Biophys. Acta 332: 69–84.

    Article  CAS  Google Scholar 

  • Lumsden, C. E., Robertson, D. M., and Blight, R., 1966, Chemical studies on experimental allergic encephalitogenic “antigens,” J. Neurochem. 13: 127–162.

    Article  PubMed  CAS  Google Scholar 

  • Lycke, E., and Roos, B.-E., 1973, Brain monoamines in guinea pigs with experimental allergic encephalomyelitis, Int. Arch. Allergy 45: 341–351.

    Article  PubMed  CAS  Google Scholar 

  • McFarland, H. F., 1970, Immunofluorescent study of circulating antibody in experimental allergic encephalomyelitis, Proc. Soc. Exptl. Biol. Med. 133: 1195–1200.

    CAS  Google Scholar 

  • McFarlin, D. E., Blank, S. E., Kibler, R. F., McKneally, S., and Shapira, R., 1973, Experimental allergic encephalomyelitis in the rat: Response to encephalitogenic proteins and peptides, Science 179: 478–480.

    Article  PubMed  CAS  Google Scholar 

  • Mackay, I. R., Carnegie, P. R., and Coates, A. S., 1973, Immunopathological comparisons between experimental autoimmune encephalomyelitis and multiple sclerosis: A review, Clin. Exp. Immunol. 15: 471–482.

    PubMed  CAS  Google Scholar 

  • Mandel, P., Nussbaum, J. L., Neskovic, N. M., Sarlieve, L. L., and Kurihara, T., 1972, Regulation of myelinogenesis, Advances in Enzyme Regulation 10: 101–117.

    Article  PubMed  CAS  Google Scholar 

  • Marks, N., and Lajtha, A., 1965, Separation of acid and neutral proteinases in brain, Biochem. 7.97: 74–83.

    Google Scholar 

  • Marks, N., and Lajtha, A., 1971, Protein and polypeptide breakdown, Handbook of Neuro- chemistry 5A : 49–140.

    Google Scholar 

  • Martenson, R. E., Deibler, G. E., and Kies, M. W., 1970, Myelin basic proteins of the rat central nervous system, Biochim. Biophys. Acta 200: 353–362.

    Article  PubMed  CAS  Google Scholar 

  • Martenson, R. E., Deibler, G. E., and Kies, M. W., 1971a, The occurrence of two myelin basic proteins in the central nervous system of rodents in the suborders Myomorpha and Sciuromorpha, J. Neurochem. 18: 2427–2433.

    Article  CAS  Google Scholar 

  • Martenson, R. E., Deibler, G. E., and Kies, M. W., 1971b, Comparison of amino acid sequences of hypothalamic peptide, brain-specific histone and myelin basic protein, Nature (New Biol.) 234: 87–89.

    CAS  Google Scholar 

  • Martenson, R. E., Deibler, G. E., Kies, M. W., Levine, S., and Alvord, E. C, Jr., 1972a, Myelin basic proteins of mammalian and submammalian vertebrates: Encephalitogenic activities in guinea pigs and rats, J. Immunol. 109: 262–270.

    PubMed  CAS  Google Scholar 

  • Martenson, R. E., Deibler, G. E, Kies, M. W., McKneally, S. S., Shapira, R., and Kibler, R. F., 1972b, Differences between the two myelin basic proteins of the rat central nervous system, Biochim. Biophys. Acta 263: 193–203.

    Article  PubMed  CAS  Google Scholar 

  • Martenson, R. E., Kramer, A. J., Deibler, G. E., and Levine, S., 1975, Comparative studies of guinea pig and bovine myelin basic proteins: Partial characterization of chemically derived fragments and their encephalitogenic activities in Lewis rats, J. Neurochem. 24: 173–182.

    Article  PubMed  CAS  Google Scholar 

  • Matthieu, J. M., Widmer, S., and Herschkowitz, N., 1973a, Biochemical changes in mouse brain composition during myelination, Brain. Res. 55: 391–402.

    Article  PubMed  CAS  Google Scholar 

  • Matthieu, J. M., Widmer, S., and Herschkowitz, N., 19736, Jimpy, an anomaly of myelin maturation: biochemical study of myelination phases, Brain Res. 55: 403–412.

    Article  PubMed  CAS  Google Scholar 

  • Matthieu, J. M., Quarles, R. H., Brady, R. O., and Webster, H., 1973c, Variation of proteins, enzyme markers and gangliosides in myelin subfractions, Biochim. Biophys. Acta 329: 305–317.

    Article  PubMed  CAS  Google Scholar 

  • Mehl, E., 1972, Separation and characterization of myelin proteins, in Functional and Structural Proteins of the Nervous System (A. N. Davison, P. Mandel, and I. G. Morgan, eds.), pp. 157–170, Plenum Press, New York.

    Chapter  Google Scholar 

  • Mehl, E., and Halaris, A., 1970, Stoichiometric relation of protein components in cerebral myelin from different species, J. Neurochem. 17: 659–668.

    Article  PubMed  CAS  Google Scholar 

  • Mehl, E., and Wolfgram, E., 1969, Myelin types with different protein components in the same species, J. Neurochem. 16: 1091–1097.

    Article  PubMed  CAS  Google Scholar 

  • Miyake, M., and Kakimoto, Y., 1973, Protein methylation by cerebral tissue, J. Neurochem. 20: 859–871.

    Article  PubMed  CAS  Google Scholar 

  • Miyamoto, E., and Kakiuchi, S., 1974, In vitro and in vivo phosphorylation of myelin basic protein by exogenous and endogenous adenosine 3Ȳ,5Ȳ-monophosphate-dependent protein kinases from brain, J. Biol. Chem. 249: 2769–2777.

    PubMed  CAS  Google Scholar 

  • Miyamoto, E., Kakiuchi, S., and Kakimoto, Y., 1974, In vitro and in vivo phosphorylation of myelin basic protein by cerebral protein kinase, Nature (London) 249: 150.

    Article  CAS  Google Scholar 

  • Morell, P., Greenfield, S., Costantino-Ceccarini, E., and Wisniewski, H., 1972, Changes in the protein composition of mouse brain myelin during development, J. Neurochem. 19: 2545–2554.

    Article  PubMed  CAS  Google Scholar 

  • Morell, P., Lipkind, R., and Greenfield, S., 1973, Protein composition of myelin from brain and spinal cord of several species, Brain Res. 58: 510–514.

    Article  PubMed  CAS  Google Scholar 

  • Morgan, I. M., 1947, Allergic encephalomyelitis in monkeys in response to injection of normal monkey nervous tissue, J. Exptl. Med. 85: 131–140.

    Article  CAS  Google Scholar 

  • Morris, S. J., Louis, C. F., and Shooter, E. M., 1971, Separation of myelin proteins on two different Polyacrylamide gel systems, Neurobiology 1: 64–67.

    CAS  Google Scholar 

  • Nakao, A., and Einstein, E. R., 1965, Chemical and immunochemical studies with the dialyzable encepholitogenic compound from bovine spinal cord, Ann. N.Y. Acad. Sci. 122: 171–181.

    Article  PubMed  CAS  Google Scholar 

  • Nakao, A., Davis, W. J., and Einstein, E. R., 1966a, Basic proteins from the acidic extract of bovine spinal cord, Biochim. Biophys. Acta 130: 171–179.

    Article  Google Scholar 

  • Nakao, A., Davis, W. J., and Einstein, E. R., 1966/?, Basic proteins from the acidic extract of bovine spinal cord, Biochim. Biophys. Acta 130: 163–170.

    Article  CAS  Google Scholar 

  • Norton, W. T., 1972, Myelin, in Basic Neurochemistry (R. W. Albers, G. J. Siegel, R. Katzman, and B. W. Agranoff, eds.), pp. 365–386, Little, Brown & Co., Boston.

    Google Scholar 

  • Norton, W. T., and Poduslo, S. E., 1973a, Myelination in rat brain: Method of myelin isolation, J. Neurochem. 21: 749–757.

    Article  PubMed  CAS  Google Scholar 

  • Norton, W. T., and Poduslo, S. E., 19736, Myelination in rat brain: Changes in myelin composition during brain maturation, J. Neurochem. 21: 759–773.

    Article  PubMed  CAS  Google Scholar 

  • Nussbaum, J. L., and Mandel, P., 1973, Brain proteolipids in neurological mutant mice, Brain Res. 61: 295–310.

    Article  PubMed  CAS  Google Scholar 

  • Olson, R. E., Klay, M., Good, R. A., and Condie, R. M., 1962, The encephalitogenic properties of bovine central nervous tissue fractions, J. Neuropath. Exptl. Neurol. 21: 461–470.

    Article  CAS  Google Scholar 

  • Oshiro, Y., and Eylar, E. H., 1970, Allergic encephalomyelitis: Preparation of the encephalitogenic basic protein from bovine brain, Arch. Biochem. 138: 392–396.

    Article  PubMed  CAS  Google Scholar 

  • Paik, W. K., and Kim, S., 1971, Protein methylation: Enzymatic methylation of proteins after translation may take part in control of biological activities of proteins, Science 174: 114–119.

    Article  PubMed  CAS  Google Scholar 

  • Paik, W. K., and Kim, S., 1973, Protein methylases during development of rat brain, Biochim. Biophys. Acta 313: 181–189.

    Article  PubMed  CAS  Google Scholar 

  • Palmer, F. B., and Dawson, R. M. C, 1969a, The isolation and properties of experimental allergic encephalitogenic protein, Biochem. J. 111: 629–636.

    PubMed  CAS  Google Scholar 

  • Palmer, F. B., and Dawson, R. M. C, 19696, Complex formation between triphosphoinositide and experimental allergic encephalitogenic proteins, Biochem. J. 111: 637–646.

    CAS  Google Scholar 

  • Palo, J., Savolainen, H., and Haltia, M., 1972, Proteins of peripheral nerve myelin in diabetic neuropathy, J. Neurol. Sci. 16: 193–199.

    Article  PubMed  CAS  Google Scholar 

  • Paty, D. W., 1971, An encephalitogenic basic protein from human peripheral nerve, Europ. Neurol. 5: 281–287.

    Article  PubMed  CAS  Google Scholar 

  • Peters, A., and Vaughn, J. E., 1970, Morphology and development of the myelin sheath, in Myelination (A. N. Davison, and A. Peters, eds.), pp. 3–79, Charles C. Thomas, Illinois.

    Google Scholar 

  • Pfeiffer, S. E., and Wechsler, W., 1972, Biochemically differentiated neoplastic clone of Schwann cells, Proc. Natl. Acad. Sci. (U.S.A.) 69: 2885–2889.

    Article  CAS  Google Scholar 

  • Pleasure, D.E., Feldmann, B., and Prockop, D. J., 1973, Diphtheria toxin inhibits the synthesis of myelin proteolipid and basic proteins by peripheral nerve in vitro, J. Neurochem. 20: 81–90.

    Article  CAS  Google Scholar 

  • Quarles, R. H., Everly, J. L., and Brady, R. O., 1973, Evidence for the close association of a glycoprotein with myelin in rat brain, J. Neurochem. 21: 1177–1191.

    Article  PubMed  CAS  Google Scholar 

  • Quelin, S., and Brahic, M., 1973, Purification of basic encephalitogenic protein from brain of sheep, C. R. Acad. Sci. (Paris) 277: 2565–2568.

    CAS  Google Scholar 

  • Raghavan, S. S., Rhoads, D. B., and Kanfer, J. N., 1973, The effects of trypsin on purified myelin, Biochim. Biophys. Acta 328: 205–212.

    Article  PubMed  CAS  Google Scholar 

  • Rauch, H. C., and Raffeis, S., 1964, Immunofluorescent localization of encephalitogenic protein in myelin, J. Immunol. 92: 452–455.

    PubMed  CAS  Google Scholar 

  • Rivers, T. M., and Schwentker, F. F., 1935, Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys, J. Exptl. Med. 61: 689–702.

    Article  CAS  Google Scholar 

  • Robertson, D. M., Blight, R., and Lumsden, C. E., 1962, Dialysable peptide as the causative factor in experimental “allergic” encephalomyelitis, Nature (London) 196: 1005.

    Article  CAS  Google Scholar 

  • Roboz, E., and Henderson, N., 1959, Preparation and properties of water soluble proteins from bovine cord with “allergic” encephalomyelitis activity, in Allergic Encephalomyelitis (M. W. Kies and E. C. Alvord, Jr., eds.), pp. 281–292, Charles C. Thomas, Illinois.

    Google Scholar 

  • Rodriguez de Lores Arnaiz, G., Aberici de Canal, M., and de Robertis, E., 1971, Turnover of proteins in subcellular fractions of rat cerebral cortex, Brain Res. 31: 179–184.

    Article  Google Scholar 

  • Sammeck, R., 1973, Myelin sheath: Turnover of myelin basic proteins during morphogenesis, in Abstracts Fourth Meeting International Society for Neurochemistry, p. 189, Tokyo.

    Google Scholar 

  • Sammeck, R., and Brady, R. O., 1972, Studies of the catabolism of myelin basic proteins in the rat in situ and in vitro, Brain Res. 42: 441–453. Sammeck, R., Martenson, R. E., and Brady, R. O., 1971, Studies of the metabolism of myelin basic proteins in various regions of the central nervous system of immature and adult rats, Brain Res. 34: 241–254.

    Google Scholar 

  • Savolainen, H. J., 1972, Proteins and glycoproteins of human myelin and glial cell membrane with special reference to myelin formation, Tower Int. Technomed. J. Life sci. 2: 35–38.

    CAS  Google Scholar 

  • Savolainen, H., and Palo, J., 1972, Proteins of human glial cell membrane, FEBS Letters 20: 71–74.

    Article  PubMed  CAS  Google Scholar 

  • Savolainen, H., Palo, J., Riekkinen, P., Moronen, P., and Brody, L. E., 1972, Maturation of myelin proteins in human brain, Brain Res. 37: 253–263.

    Article  PubMed  CAS  Google Scholar 

  • Scheinberg, L. C, and Korey, S. R., 1958, Studies of white matter, J. Neuropathol. Exptl. Neurol 17: 439–449.

    Article  CAS  Google Scholar 

  • Shapira, R., Chou, F. C-H., McKneally, S. S., Urban, E., and Kibler, R. F., 1971a, Biological activity and synthesis of an encephalitogenic determinant, Science 173: 736–738.

    Article  PubMed  CAS  Google Scholar 

  • Shapira, R., McKneally, S. S., Chou, F., and Kibler, R. F., 19716, Encephalitogenic fragment of myelin basic protein, J. Biol. Chem. 246: 4630–4640.

    CAS  Google Scholar 

  • Shooter, E. M., and Einstein, E. R., 1971, Proteins of the nervous system, Ann. Rev. Biochem. 40: 635–652.

    Article  PubMed  CAS  Google Scholar 

  • Smith, M., 1968, The turnover of myelin in the adult rat, Biochim. Biophys. Acta 164: 285–293.

    Article  PubMed  CAS  Google Scholar 

  • Smith, M., 1972, The turnover of myelin proteins, Neurobiology 2: 35–40.

    PubMed  CAS  Google Scholar 

  • Smith, M. E., 1973a, A regional survey of myelin development: Some compositional and metabolic aspects, J. Lipid Res. 14: 541–551.

    PubMed  CAS  Google Scholar 

  • Smith, M. E., 19736, Studies of the mechanism of demyelination: Triethyl tin induced demyelination, J. Neurochem. 21: 357–372.

    Article  PubMed  CAS  Google Scholar 

  • Smythies, J. R., Benington, F., and Morin, F. D., 1970, Specifications of a possible serotonin receptor site in the brain, Neurosciences Res. Prog. Bull. 8: 117–122.

    Google Scholar 

  • Soto, E. F., 1964, Induction of experimental allergic encephalomyelitis with a myelin fraction obtained from bovine white matter. Neurology 14: 938–948.

    Article  PubMed  CAS  Google Scholar 

  • Steck, A. J., and Appel. S. H., 1974, Phosphorylation of myelin basic protein, J. Biol. Chem. 249: 5416–5420.

    PubMed  CAS  Google Scholar 

  • Sundarraj, N., and Pfeiffer, S. E., 1973, Myelin basic protein arginine methyl transferase: Wide distribution among both neurogenic and non-neurogenic tissues, Biochem. Biophys. Res. Commun. 52: 1039–1045.

    Article  PubMed  CAS  Google Scholar 

  • Tomasi, L., and Kornguth, S. E., 1967, Purification and partial characterization of a basic protein from pig brain, J. Biol. Chem. 242: 4933–4938.

    PubMed  CAS  Google Scholar 

  • Uyemura, K., Tobari, C, and Hirano, S., 1970, Purifications and properties of basic proteins in pig spinal cord and peripheral nerve, Biochim. Biophys. Acta 214: 190–197.

    Article  PubMed  CAS  Google Scholar 

  • Uyemura, K., Tobari, C, Hirano, S., and Tsukada, Y., 1972, Comparative studies on the myelin proteins of bovine peripheral nerve and spinal cord, J. Neurochem. 19: 2607–2614.

    Article  PubMed  CAS  Google Scholar 

  • Uyemura, K., Kitamura, K., and Ogawa, Y., 1975, Studies on the antigenic protein to induce experimental allergic neuritis (EAN), Acta Neuropathologica (in press).

    Google Scholar 

  • Westall, F. C, 1972, Solid phase peptide synthesis as applied to experimental allergic encephalomyelitis, in Multiple Sclerosis (E. J. Field, T. M. Bell, and P. R. Carnegie, eds.), pp. 72–79, North-Holland Publ. Co., Amsterdam.

    Google Scholar 

  • Westall, F. C, 1973, An explanation for the determination of “self and “non-self proteins, J. Theoret. Biol. 38: 139–141.

    Article  CAS  Google Scholar 

  • Westall, F. C, 1974, Released myelin basic protein: The immunogenic factor? Immunochemistry. 11: 513–515.

    Article  PubMed  CAS  Google Scholar 

  • Westall, F. C, Robinson, A. B., Caccam, J., Jackson, J., and Eylar, E. H., 1971, Essential chemical requirements for induction of allergic encephalomyelitis, Nature (London) 229: 22–24.

    Article  CAS  Google Scholar 

  • White, S. R., White, F. P., Barnes, C. D., and Albright, J. F., 1973, Increased shock sensitivity in rats with experimental allergic encephalomyelitis and reversal by 5-hydroxytryptophan, Brain Res. 58: 251–254.

    Article  PubMed  CAS  Google Scholar 

  • Whittingham, S., Bencina, B., Carnegie, P. R., and McPherson, T. A., 1972, Properties of antibodies produced in rabbits to human myelin and myelin basic protein, Int. Arch. Allergy Appl. Immunol. 42: 250–263.

    Article  PubMed  CAS  Google Scholar 

  • Wolman, M., 1971, Distribution of various protein fractions in central and peripheral myelin, Exptl. Neurol. 30: 309–323.

    Article  CAS  Google Scholar 

  • Wood, J. G., and Dawson, R. M. C, 1973a, A major myelin glycoprotein of sciatic nerve, J. Neurochem. 21: 717–719.

    Article  PubMed  CAS  Google Scholar 

  • Wood, J. G., and Dawson, R. M. C, 19736, The effect of trypsin on the proteins and lipids of myelin, in “Abstracts Fourth Meeting International Society for Neurochemistry,” Tokyo, p.187.

    Google Scholar 

  • Wood, J. G., and King, N., 1971, Turnover of basic protein of rat brain, Nature (London) 229: 56–58.

    Article  CAS  Google Scholar 

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  1. The Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Australia

    Patrick R. Carnegie & Peter R. Dunkley

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  1. Patrick R. Carnegie
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  1. Mental Health Research Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA

    B. W. Agranoff

  2. Institute of Psychiatric Research and Department of Psychiatry and Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana, USA

    M. H. Aprison

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Carnegie, P.R., Dunkley, P.R. (1975). Basic Proteins of Central and Peripheral Nervous System Myelin. In: Agranoff, B.W., Aprison, M.H. (eds) Advances in Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4395-1_3

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