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Advances in Neurochemistry pp 1–49Cite as

Possible Roles of Prostaglandins in the Nervous System

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Abstract

Few would question that one of the most exciting and important developments in biochemistry and physiology in recent years has been the emergence of prostaglandins as a new class of molecules mediating and modulating hormonal, neurohormonal, or other stimuli on most mammalian tissues. In just over ten years the literature on prostaglandins has expanded to over 5000 references, from basic chemistry, metabolism, and pharmacology to clinical trials of natural prostaglandins and synthetic analogues. Although the subject is recent, one can look back at the work of others over the 30 years before the announcement of the structures of the six primary prostaglandins by Bergström and coworkers (Bergström et al., 1962, 1963; review, 1968) and identify principles with biological activities that we now know are mainly due to prostaglandins. Foremost among these were the independent observations of Kurzrok and Lieb (), Goldblatt (1933, 1935), and von Euler (1934, 1935a) that human semen and extracts of sheep vesicular glands contained factors that stimulated intestinal and uterine muscle and lowered arteral blood prossure. Von Euler (1935b) showed that these activities were due to acidic lidic lipids and proposed the name “prostaglandin”.

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  1. Donner Laboratory of Experimental Neurochemistry, Montreal Neurological Institute, McGill University, H3A 2B4, Montreal, Quebec, Canada

    Leonhard S. Wolfe

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  1. Leonhard S. Wolfe
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  1. Mental Health Research Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA

    B. W. Agranoff

  2. Institute of Psychiatric Research and Department of Psychiatry and Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana, USA

    M. H. Aprison

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Wolfe, L.S. (1975). Possible Roles of Prostaglandins in the Nervous System. In: Agranoff, B.W., Aprison, M.H. (eds) Advances in Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4395-1_1

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