Islet Transplantation

  • Bernhard J. Hering
  • Martin Wijkstrom
  • Peter M. Eckman


Type 1 diabetes continues to represent a therapeutic challenge and consequently remains a substantial burden for patients and their families. Secondary diabetes complications, observed in 30% to 50% of patients affected by type 1 diabetes, result in poor quality of life, premature death, and considerable healthcare costs.1 The principal determinant of the risk of devastating diabetes complications is the total lifetime exposure to elevated blood glucose levels.2 Therefore, establishing safe and effective methods of achieving and maintaining normoglycemia will have substantial implications for the health and quality of life of individuals with diabetes. The Diabetes Control and Complications Trial (DCCT) demonstrated that, given a qualified diabetes care team and intensive insulin treatment control, near-normalization of glycemia could be achieved and sustained for several years. However, such a near-perfect level of treatment would increase a patients burden of day-to-day diabetes management, be difficult to implement for many patients, require more attention and medical services than are routinely available in clinical practice,3 and be accompanied by an increased frequency of severe hypoglycemia2 (chapter 3).


Human Islet Islet Transplant Islet Graft Islet Isolation Mixed Chimerism 
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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Bernhard J. Hering
  • Martin Wijkstrom
  • Peter M. Eckman

There are no affiliations available

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