Diabetes Mellitus: Pathogenesis and Natural History

  • Jay S. Skyler


Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia arising as a consequence of a relative or absolute deficiency of insulin secretion, resistance to insulin action, or both.1,2 Although diabetes mellitus is recognized by its characteristic hyperglycemia, the metabolic derangements are more pervasive, involving altered metabolism of carbohydrates, fats, and proteins. As a function of time and consequent to the metabolic disruption, diabetic patients may suffer the tragic ravages of long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels.


Glycemic Control Diabetic Nephropathy Diabetic Retinopathy Autonomic Neuropathy Diabetic Macular Edema 
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© Springer Science+Business Media New York 2004

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  • Jay S. Skyler

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