Multiple New Isoforms of the Human Prolactin Receptor Gene
Prolactin (PRL) is a polypeptide hormone with a clear role in promoting mammary gland growth, differentiation, and lactogenesis. In addition, endocrine and/or autocrine/ paracrine PRL (Clevenger et al. 1995; Ginsburg & Vonderhaar 1995) promotes mammary carcinogenesis in rodents (Wennbo et al. 1997) and also may contribute to the initiation and progression of human breast cancer (Hankinson et al. 1999).
KeywordsCorrespond Author Chloramphenicol Acetyl Transferase Prolactin Receptor Short Isoforms Dominant Negative
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- Bignon C, Binart N, Ormandy C, Schuler LA, Kelly PA, Djiane J. Long and short forms of the ovine prolactin receptor: cDNA cloning and genomic analysis reveal that the two forms arise by different alternative splicing mechanisms in ruminants and in rodents. J Mol Endocrinol 1997;19:109–120.PubMedCrossRefGoogle Scholar
- Ginsburg E, Vonderhaar BK. Prolactin synthesis and secretion by human breast cancer cells. Cancer Res 1995;55:2591–2595.Google Scholar