Abstract
Lactoferrin (Lf), an 80-kD glycoprotein, is a major whey protein in human milk (HM). The structure of Lf is similar to that of transferrin and ovotransferrin. Lactoferrin binds iron tightly and releases it at a pH less than 3.0 (Lonnerdal & Iyer 1995), has anti-inflammatory and antibacterial properties (Goldman et al. 1990), and has antioxidant properties (Huang et al. 1999).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Conneely OM. Antiinflammatory activities of lactoferrin. J Am Coll Nutr 2001;20:389S–395S; discussion 396S–397S.
Goldman AS, Goldblum RM, Hanson LA. Anti-inflammatory systems in human milk. Adv Exp Med Biol 1990;262:69–76.
Huang SW, Satue-Gracia MT, Frankel EN, German JB. Effect of lactoferrin on oxidative stability of corn oil emulsions and liposomes. J Agric Food Chem 1999;47:1356–1361.
Lonnerdal B, Forsum E, Hambraeus L. A longitudinal study of the protein, nitrogen, and lactose contents of human milk from Swedish well-nourished mothers. Am J Clin Nutr 1976;29:1127–1133.
Lonnerdal B, Iyer S. Lactoferrin: molecular structure and biological function. Annu Rev Nutr 1995;15:93–110.
Montagne P, Cuillière M, Molé C, Béné M, Faure G. Dynamics of the Main Immunologically and Nutritionally Available Proteins of Human Milk during Lactation. J Food Comp Anal 2000;13:127–137.
Nagasawa T, Kiyosawa I, Kuwahara K. Amounts of lactoferrin in human colostrum and milk. J Dairy Sci 1972;55:1651–1659.
Ronayne de Ferrer PA, Baroni A, Sambucetti ME, Lopez NE, Ceriani Cernadas JM. Lactoferrin levels in term and preterm milk. J Am Coll Nutr 2000;19:370–373.
Sanchez-Pozo A, Lopez J, Pita ML, Izquierdo A, Guerrero E, Sanchez-Medina F, Martinez Valverde A, Gil A. Changes in the protein fractions of human milk during lactation. Ann Nutr Metab 1986;30:15–20.
Zavaleta N, Nombera J, Rojas R, Hambraeus L, Gislason J, Lönnerdal B. Iron and lactoferrin in milk of anemic mothers given iron supplements Nutr Res. 1995; 15:681–690.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Springer Science+Business Media New York
About this paper
Cite this paper
Lien, E., Jackson, J., Kuhlman, C., Pramuk, K., Lönnerdal, B., Janszen, D. (2004). Variations in Concentrations of Lactoferrin in Human Milk: A Nine Country Survey. In: Pickering, L.K., Morrow, A.L., Ruiz-Palacios, G.M., Schanler, R.J. (eds) Protecting Infants through Human Milk. Advances in Experimental Medicine and Biology, vol 554. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4242-8_55
Download citation
DOI: https://doi.org/10.1007/978-1-4757-4242-8_55
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-3461-1
Online ISBN: 978-1-4757-4242-8
eBook Packages: Springer Book Archive