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Aspirin in Stroke Prevention

  • Chapter
Prevention of Stroke

Abstract

Aspirin is now standard preventive therapy in patients at risk for stroke, but many questions remain about its efficacy and use. No single trial has clearly demonstrated the efficacy of aspirin for prevention of stroke after transient ischemic attack (TIA). However, almost all studies showed some benefit in the aspirin group. Recently, metaanalysis, integrating and analyzing data from multiple studies, has attempted to clarify the picture. One such analysis1 showed no significant benefit for aspirin alone. Another analysis was carried out in collaboration with the principal investigators of all studies of platelet antiaggregate drugs for prevention of vascular disease, and weighted the studies according to the numbers of patients in each. This represented 25 completed studies enrolling 29 000 patients with angina, myocardial infarction, TIA, or stroke.

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Authors
  1. James C. Grotta
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Editor information

Editors and Affiliations

  1. Department of Neurology, Sunnybrook Health Science Centre, University of Toronto, Toronto, Ontario, M4N 3M5, Canada

    John W. Norris M.D.

  2. Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, N6A 5A5, Canada

    Vladimir C. Hachinski M.D.

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© 1991 Springer Science+Business Media New York

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Grotta, J.C. (1991). Aspirin in Stroke Prevention. In: Norris, J.W., Hachinski, V.C. (eds) Prevention of Stroke. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4226-8_9

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  • DOI: https://doi.org/10.1007/978-1-4757-4226-8_9

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-4228-2

  • Online ISBN: 978-1-4757-4226-8

  • eBook Packages: Springer Book Archive

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