Skip to main content

Prevention of Aneurysmal Subarachnoid Hemorrhage

  • Chapter
Prevention of Stroke
  • 161 Accesses

Abstract

Approximately 1 to 20% of the general adult population harbor a saccular cerebral aneurysm, which is an acquired lesion resulting from prolonged hemodynamic stress at unsupported bifurcations and angles in major cerebral arteries traversing the subarachnoid space. A more liberal application of computerized tomography (CT) in the investigation of unusual headaches could facilitate recognition of minor hemorrhages that frequently precede major, devastating aneurysm ruptures. Rebleeding is a major cause of death and disability in survivors of aneurysm rupture, and the rate of rebleeding is highest on the first 2 days following the initial hemorrhage. If treated with bed rest alone, approximately 20% of patients will rebleed within 14 days, 30% in 30 days, 40% in 180 days, and thereafter patients will continue to rebleed at the rate of about 3% per year.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Torner JC. Epidemiology of subarachnoid hemorrhage. Sem Neurol. 1984;4:354–369.

    Article  Google Scholar 

  2. Sahs AL, Nibbelink DW, Torner JC, eds. Aneurysmal Subarachnoid Hemorrhage. Baltimore, MD: Urban and Schwarzenberg; 1981.

    Google Scholar 

  3. Gillingham FJ. The management of ruptured intracranial aneurysms. Scott Med J. 1967;12:377–383.

    PubMed  CAS  Google Scholar 

  4. Okawara S. Warning signs prior to rupture of an intracranial aneurysm. J Neurosurg. 1973;38:575–580.

    Article  PubMed  CAS  Google Scholar 

  5. Waga S, Ohtsubo K, Handa H. Warning signs in intracranial aneurysms. Surg Neurol. 1975;3:5–20.

    Google Scholar 

  6. Leblanc R. The minor leak preceding subarachnoid hemorrhage. J Neurosurg. 1987;66:35–39.

    Article  PubMed  CAS  Google Scholar 

  7. Kassell NF, Kongable GL, Torner JC, et al. Delay in referral of patients with ruptured aneurysms to neurosurgical attention. Stroke. 1985;16:587–590.

    Article  PubMed  CAS  Google Scholar 

  8. Verweij RD, Wijdicks FM, Van Gijn J. Warning Headache in Aneurysmal Subarachnoid Hemorrhage. Arch Neurol. 1988;45:1019–1021.

    Article  PubMed  CAS  Google Scholar 

  9. Drake CG. Management of cerebral aneurysm. Stroke. 1981;12:273–283.

    Article  PubMed  CAS  Google Scholar 

  10. Adams HP Jr, Kassell NF, Torner JC. Usefulness of computed tomography in predicting outcome after aneurysmal subarachnoid hemorrhage: a preliminary report of the Cooperative Aneurysm Study. Neurology. 1985;35:1263–1267.

    Article  PubMed  Google Scholar 

  11. Kistler JP, Crowell RM, Davis KR, et al. The relation of cerebral vasospasm to the extent and location of subarachnoid blood visualized by CT scan: a prospective study. Neurology. 1983;33:424–436.

    Article  PubMed  CAS  Google Scholar 

  12. Duffy GP. Lumbar puncture in spontaneous subarachnoid hemorrhage. Br M J. 1982;285:1163–1164.

    Article  CAS  Google Scholar 

  13. Jenkins A, Hadley DM, Teasdale GM, et al. Magnetic resonance imaging of acute subarachnoid hemorrhage. J Neurosurg. 1988;68:731–736.

    Article  PubMed  CAS  Google Scholar 

  14. Di Chiro G, Brooks RA, Girton ME, et al. Sequential MR studies of intracerebral hematomas in monkeys. AJNR. 1986;7:193–199.

    PubMed  Google Scholar 

  15. Stone JL, Crowell RM, Gandhi YN, et al. Multiple intracranial aneurysms: Magnetic resonance imaging for determination of the site of rupture. Report of a case. Neurosurgery. 1988;23:97–100.

    Article  PubMed  CAS  Google Scholar 

  16. Pakarinen S. Incidence, aetiology, and prognosis of primary subarachnoid hemorrhage. A study based on 589 cases diagnosed in a defined urban population during a defined period. Acta Neurol Scand. 1967;43(suppl 29): 1–128.

    PubMed  Google Scholar 

  17. Suzuki J, Hori S. Prediction of reattacks following rupture of intracranial aneurysms. Neurol Med Chir. 1975;15(part 1):35–39.

    Article  Google Scholar 

  18. Kassell NF, Torner JC. Aneurysmal rebleeding: a preliminary report from the Cooperative Aneurysm Study. Neurosurgery. 1983;13:479–481.

    Article  PubMed  CAS  Google Scholar 

  19. Jane JA, Kassell NF, Torner JC, et al. The natural history of aneurysms in arteriovenous malformations. J Neurosurg. 1985;62:321–323.

    Article  PubMed  CAS  Google Scholar 

  20. Hillman J, von Essen C, Leszniewski W, et al. Significance of “ultra-early” rebleeding in subarachnoid hemorrhage. J Neurosurg. 1988;68:901–907.

    Article  PubMed  CAS  Google Scholar 

  21. Rosenorn J, Eskesen V, Schmidt K, et al. The risk of rebleeding from ruptured intracranial aneurysms. J Neurosurg 1987;67:329–332.

    Article  PubMed  CAS  Google Scholar 

  22. Nishioka H, Torner JC, Graf CJ, et al. Cooperative study of intracranial aneurysms in subarachnoid hemorrhage: a long term prognostic study: II. Ruptured intracranial aneurysms managed conservatively. Arch Neurol. 1984;41:1142–1146.

    Article  PubMed  CAS  Google Scholar 

  23. Torner JC, Kassell NF, Wallace RB, et al. Preoperative prognostic factors for rebleeding and survival in aneurysm patients receiving antifibrinolytic therapy: report of the Cooperative Aneurysm study. Neurosurgery 1981;9:506–513.

    Article  PubMed  CAS  Google Scholar 

  24. O’Neill P, West CR, Chadwick DW, et al. Recurrent aneurysmal subarachnoid hemorrhage: incidence, timing and effects. A re-appraisal in a surgical series. Br J Neurosurg. 1988;2:43–48.

    Article  PubMed  Google Scholar 

  25. Flamm ES. The timing of aneurysm surgery 1985. Clin Neurosurg. 1985;33:147–158.

    Google Scholar 

  26. Kassell NF, Drake CG. Timing of aneurysm surgery. Neurosurgery. 1982;10:514–519.

    Article  PubMed  CAS  Google Scholar 

  27. Mizukami M, Usami T, Tazawa T, et al. Prevention of vasospasm by removal of subarachnoid blood in early operation. Neurol Med Chir. 1981;21:1069–1077.

    Article  CAS  Google Scholar 

  28. Taneda M. Effect of early operation for ruptured aneurysms on prevention of delayed ischemic symptoms. J Neurosurg. 1982;57:622–628.

    Article  PubMed  CAS  Google Scholar 

  29. Kassell NF, Peerless SG, Durward QJ, et al. Treatment of ischemic deficits from vasospasm with intravascular volume expansion and induced arterial hypertension. Neurosurgery. 1982;11:337–343.

    Article  PubMed  CAS  Google Scholar 

  30. Ljunggren B, Brandt L. Timing of aneurysm surgery. Clin Neurosurg. 1985;33:159–175.

    Google Scholar 

  31. Hunt WE. Timing of surgery for intracranial aneurysm. In: Wilkins RH, ed. Cerebral Arterial Spasm. Baltimore: Williams & Wilkins; 1980.

    Google Scholar 

  32. Lougheed WM. Selection, timing and technique of aneurysm surgery of the anterior circle of Willis. Clin Neurosurg. 1968;16:95–113.

    Google Scholar 

  33. Kassell NF, Boarini DJ, Adams HP Jr, et al. Overall management of ruptured aneurysm: Comparison of early and late operation. Neurosurgery. 1981;9:120–128.

    Article  PubMed  CAS  Google Scholar 

  34. Weir B, Aronyk K. Management mortality and the timing of surgery for supratentorial aneurysms. J Neurosurg. 1981;54:146–150.

    Article  PubMed  CAS  Google Scholar 

  35. Saito I, Sano K. Timing and indication of surgery for ruptured cerebral aneurysms. Neurol Med Chir. 1981;21:261–267.

    Article  CAS  Google Scholar 

  36. Suzuki K, Kodama N, Yoshimoto T, et al. Ultraearly surgery of intracranial aneurysms. Acta Neurochir (Wien) 1982;63:185–191.

    Article  CAS  Google Scholar 

  37. Ljunggren B, Brandt L, Sundbarg G, et al. Early management of aneurysmal subarachnoid hemorrhage. Neurosurgery. 1982;11:412–418.

    Article  PubMed  CAS  Google Scholar 

  38. Ljunggren B, Saveland H, Brandt L, et al. Early operation and overall outcome in aneurysmal subarachnoid hemorrhage. J Neurosurg 1985;62:547–551.

    Article  PubMed  CAS  Google Scholar 

  39. Kassell NF, Tornor JC, Haley EC, Jr., et al. The International Coopeative Study on the Timing of Aneurysm Surgery. Part 1: Overall management results. J Neurosurg. 1990;73:18–36.

    Article  PubMed  CAS  Google Scholar 

  40. Kassell NF, Torner JC, Jane JA, et al. The International Cooperative Study on the Timing of Aneurysm Surgery. Part 2: Surgical results. J Neurosurg. 1990;73:37–47.

    Article  PubMed  CAS  Google Scholar 

  41. Chyatte D, Fode NC, Sundt TM Jr. Early versus late intracranial aneurysm surgery in subarachnoid hemorrhage. J Neurosurg. 1988;69:326–331.

    Article  PubMed  CAS  Google Scholar 

  42. Ohman J, Heiskanen O. Timing of operation for ruptured supratentorial aneurysms: a prospective randomized study. J Neurosurg. 1989;70:55–60.

    Article  PubMed  CAS  Google Scholar 

  43. Disney L, Weir B, Petruk K. Effect on management mortality as a deliberated policy of early operation on supratentorial aneurysms. Neurosurgery. 1987; 20:695–701.

    Article  PubMed  CAS  Google Scholar 

  44. Kassel! NF, Torner JC, Adams HP Jr. Antifibrinolytic therapy in the acute period following aneurysmal subarachnoid hemorrhage: preliminary observations from the Cooperative Aneurysm study. J Neurosurg. 1984;61:225–230.

    Article  Google Scholar 

  45. Vermeulen M, Lindsay KW, Murray GD, et al. Antifibrinolytic treatment in subarachnoid hemorrhage. N Engl J Med. 1984;311:432–437.

    Article  PubMed  CAS  Google Scholar 

  46. Drake CG, Vanderlinden RG. The late consequences of incomplete surgical treatment of cerebral aneurysms. J Neurosurg. 1967;27:226–238.

    Article  PubMed  CAS  Google Scholar 

  47. Drake CG, Allcock JM. Postoperative angiography and the “slipped” clip. J Neurosurg. 1973;39:683–689.

    Article  PubMed  CAS  Google Scholar 

  48. Lin T, Fox AJ, Drake CG. Regrowth of aneurysm sacs from residual neck following aneurysm clipping. J Neurosurg. 1989;70:556–560.

    Article  PubMed  CAS  Google Scholar 

  49. Feuerberg I, Lindquist C, Lindqvist M, et al. Natural history of postoperative aneurysm rests. J Neurosurg. 1987;66:30–34.

    Article  PubMed  CAS  Google Scholar 

  50. Yasargil MG. Microneurosurgery. Vol. 2. Stuttgart: Georg Thieme Verlag; 1984.

    Google Scholar 

  51. Kak VK, Taylor AR, Gordon DS. Proximal carotid ligation for internal carotid aneurysms. A long-term follow-up study. J Neurosurg. 1973;39:503–513.

    Article  PubMed  CAS  Google Scholar 

  52. Miller JD, Jawa DK, Jennett B. Safety of carotid ligation and its role in the management of intracranial aneurysms. J Neurol Neurosurg Psychiatry. 1977;40:64–72.

    Article  PubMed  CAS  Google Scholar 

  53. Fox AJ, Vinuela F, Pelz DM, et al. Use of detachable balloons for proximal artery occlusion in the treatment of unclippable cerebral aneurysms. J Neurosurg. 1987;66:40–46.

    Article  PubMed  CAS  Google Scholar 

  54. Peerless SJ, Hampf CR. Extracranial to intracranial bypass in the treatment of aneurysms. Clin Neurosurg. 1984;32:114–154.

    Google Scholar 

  55. Diste GN, Beck D. De novo aneurysm formation following carotid ligation: case report and review of the literature. Neurosurgery. 1989;24: 88–92.

    Article  Google Scholar 

  56. Sahs AL, Perret GE, Locksley HB, et al. Intracranial aneurysms in subarachnoid hemorrhage. A cooperative study. Philadelphia: Lippincott; 1969.

    Google Scholar 

  57. Nehls DG, Flom RA, Carter LP, et al. Multiple intracranial aneurysms: determining the site of rupture. J Neurosurg. 1985;63:342–348.

    Article  PubMed  CAS  Google Scholar 

  58. Wood EH. Angiographic identification of the ruptured lesion in patients with multiple cerebral aneurysms. J Neurosurg. 1964;21:182–198.

    Article  PubMed  CAS  Google Scholar 

  59. Stehbens WE. The pathology of intracranial arterial aneurysms and their complications. In: Fox JL, ed. Intracranial Aneurysms. Vol. 1. New York, NY: Springer-Verlag; 1983: pp 272–357.

    Chapter  Google Scholar 

  60. Atkinson JLD, Sundt TM Jr, Houser OW, et al. Angiographic frequency of anterior circulation intracranial aneurysms. J Neurosurg. 1989;70:551–555.

    Article  PubMed  CAS  Google Scholar 

  61. Heiskanen O. Risk of rebleeding from unruptured aneurysms in cases with multiple intracranial aneurysms. J Neurosurg. 1981;55:524–526.

    Article  PubMed  CAS  Google Scholar 

  62. Locksley HB. Report on the cooperative study of intracranial aneurysms and subarachnoid hemorrhage: Section V, part II. Natural history of subarachnoid hemorrhage, intracranial aneurysms and arteriovenous malformations. Based on 6368 cases in the Cooperative Study. J Neurosurg. 1966;25: 219–239.

    Article  PubMed  CAS  Google Scholar 

  63. Wiebers DO, Whisnant JP, Sundt TM Jr, et al. The significance of unruptured intracranial saccular aneurysms. J Neurosurg. 1987;66:23–29.

    Article  PubMed  CAS  Google Scholar 

  64. Weir B. Intracranial aneurysms and subarachnoid hemorrhage: An overview. In: Wilkins RH, Rengachary SS, eds. Neurosurgery. New York: McGrawHill; 1985.

    Google Scholar 

  65. Wirth FP, Laws ER Jr, Piepgras D, et al. Surgical treatment of incidental intracranial aneurysms. Neurosurgery. 1983;12:507–511.

    Article  PubMed  CAS  Google Scholar 

  66. Hyland HH, Barnett HJM. The pathogenesis of cranial nerve palsies associated with intracranial aneurysms. Proc R Soc Med. 1954;47:141–146.

    PubMed  CAS  Google Scholar 

  67. Fisher M, Davidson RI, Marcos EM. Transient focal cerebral ischemia as a presenting manifestation of unruptured cerebral aneurysms. Annals Neurol. 1980;8:367–372.

    Article  CAS  Google Scholar 

  68. Stewart RM, Sampson DL, Diehl J, et al. Unruptured cerebral aneurysms presenting as recurrent transient neurologic deficits. Neurology. 1980;30: 47–51.

    Article  PubMed  CAS  Google Scholar 

  69. Hassler O, Saltzman G-F. Angiographic and histologic changes in infundibular widening of the posterior communicating artery. Acta Radiol. 1963; 1:321–327.

    Article  Google Scholar 

  70. Archer CR, Silbert S. Infundibula may be clinically significant. Neuroradiology. 1978;15:247–251.

    Article  PubMed  CAS  Google Scholar 

  71. Itakura T, Ozaki F, Nakai E, et al. Bilateral aneurysm formation developing from junctional dilatation (infundibulum) of the posterior communicating arteries: case report. J Neurosurg. 1983; 58:117–119.

    Article  PubMed  CAS  Google Scholar 

  72. Misra BK, Whittle IR, Steers AJ, et al. De novo saccular aneurysms. Neurosurgery. 1988;23:10–15.

    Article  PubMed  CAS  Google Scholar 

  73. Weir B. Aneurysms Affecting the Nervous System. Baltimore: Williams & Wilkins; 1987:54–74.

    Google Scholar 

  74. George B, Mourier KL, Galbert F, et al. Vascular abnormalities in the neck associated with intracranial aneurysms. Neurosurgery. 1989;24:499–508.

    Article  PubMed  CAS  Google Scholar 

  75. Stehbens WE. Hypertension and cerebral aneurysms. Med J Aust. 1962;2:8–10.

    Google Scholar 

  76. Weil STM, Olivi A, Greiner AL, et al. Multiple intracranial aneurysms in identical twins. Acta Neurochir (Wien) 1988;95:121–125.

    Article  CAS  Google Scholar 

  77. Lozano AM, Leblanc R. Familial intracranial aneurysms. J Neurosurg. 1987;66:522–528.

    Article  PubMed  CAS  Google Scholar 

  78. Neil-Dwyer G, Barlett JR, Nicholls AC, et al. Collagen deficiency in ruptured cerebral aneurysm. A clinical and biochemical study. J Neurosurg. 1983;59:16–20.

    Article  PubMed  CAS  Google Scholar 

  79. Ostergaard JR, Oxlund H. Collagen type III deficiency in patients with rupture of intracranial saccular aneurysms. J Neurosurg. 1987;67:690–696.

    Article  PubMed  CAS  Google Scholar 

  80. Leblanc R, Lozano AM, Vanderest M, et al. Absence of collagen deficiency in familial cerebral aneurysms. J Neurosurg. 1989;70:837–840.

    Article  PubMed  CAS  Google Scholar 

  81. Stehbens WE. Etiology of intracranial berry aneurysms. J Neurosurg. 1989;70: 823–831.

    Article  PubMed  CAS  Google Scholar 

  82. McCormick WF, Schmalstieg EJ. The relationship of arterial hypertension to intracranial aneurysms. Arch Neurol. 1977;34:285–287.

    Article  PubMed  CAS  Google Scholar 

  83. Schmid UD, Steiger HJ, Huber P. Accuracy of high resolution computed tomography in direct diagnosis of cerebral aneurysms. Neuroradiology. 1987;29: 152–159.

    Article  PubMed  CAS  Google Scholar 

  84. Ross JS, Masaryk TJ, Modic MT, et al. Intracranial Aneurysms: Evaluation by MR Angiography. AJNR 1990;11:449–456.

    PubMed  CAS  Google Scholar 

  85. Pernicone JR, Siebert JE, Potchen EJ, et al. Threedimensional phase-contrast MR angiography in head and neck: preliminary report. AJNR 1990;11: 457–466.

    PubMed  CAS  Google Scholar 

  86. Weir BKA. The management of intracranial aneurysms —prospects for improvement. Clin Neurosurg 1986;34:154–160.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Findlay, J.M., Weir, B.K.A. (1991). Prevention of Aneurysmal Subarachnoid Hemorrhage. In: Norris, J.W., Hachinski, V.C. (eds) Prevention of Stroke. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4226-8_20

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-4226-8_20

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-4228-2

  • Online ISBN: 978-1-4757-4226-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics