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Prevention of Stroke pp 19–36Cite as

Cellular Basis of Atherosclerosis

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Abstract

Atherosclerosis, involving the large extracranial arteries, is a common substrate for the development of ischemic stroke in the anterior or posterior cerebral circulations. Additionally, intracranial atherosclerosis may also be causally related to ischemic stroke, especially in non-white populations.1 Many patients with large-vessel cerebral atherosclerosis harbor such lesions in other critical vessels, such as the coronary arteries, aorta, and lower extremity vessels. 2 Atherosclerosis is a ubiq- uitous problem in industrialized society, and although mortality secondary to acute myocardial infarction (MI) and ischemic stroke have declined, these twin scourges still cause over 600,000 deaths annually in the United States. 3,4 Atherogenesis is an insidious process that develops over decades and may go undetected or unrecognized until the appearance of a devastating MI or stroke. Much has been learned about the nature and pathogenesis of atherosclerosis.5

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  1. Marc Fisher
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Editors and Affiliations

  1. Department of Neurology, Sunnybrook Health Science Centre, University of Toronto, Toronto, Ontario, M4N 3M5, Canada

    John W. Norris M.D.

  2. Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, N6A 5A5, Canada

    Vladimir C. Hachinski M.D.

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Fisher, M. (1991). Cellular Basis of Atherosclerosis. In: Norris, J.W., Hachinski, V.C. (eds) Prevention of Stroke. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4226-8_2

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  • DOI: https://doi.org/10.1007/978-1-4757-4226-8_2

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