Abstract
Thyroid scintigraphy plays an important role in the evaluation of the thyroid gland owing to the functional and anatomic information it simultaneously provides. Both iodine-123 (123I) and tech-netium-99m (99mTc) may be used for diagnostic evaluation of the pediatric thyroid gland. The major indications for thyroid scintigraphy in children include neck masses, hypothyroidism, and hyperthyroidism.35 Iodine-131 (131I) has limited application in pediatric thyroid scintigraphy owing to its high radiation absorbed dose. Iodine-131 is employed in the treatment of hyperthyroidism in patients who do not respond to medical therapy or who are not compliant or who refuse surgery. Iodine-131 is used in patients with metastatic papillary carcinoma of the thyroid for the measurement of radioiodine turnover in metastases prior to 131I therapy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Attie JN. Thyroid carcinoma in children and adolescents. In Lifshitz F (ed): Pediatric Endocrinology. New York: Marcel Dekker, 1990:513–525
Attie JN, Khafif RA. Preservation of parathyroid glands during total thyroidectomy: improved technique utilizing microsurgery. Am J Surg 1975; 130:339–404
Balon HR, Fink-Bennett D, Stoffer SS. Technetium-99m-sestamibi uptake by recurrent Hurthle cell carcinoma of the thyroid. J Nucl Med 1992;33: 1393–1395
Beierwaltes WH, Nishiyama RH, Thompson NW, Copp JE, Kubo A. Survival time and “cure” in papillary and follicular carcinoma with distant metastases: statistics following University of Michigan therapy. J Nucl Med 1982;23:561–568
Bleichrodt RP, Vermey A, Piers DA, de Langen ZG. Early and delayed thallium 201 imaging: diagnosis of patients with cold thyroid nodules. Cancer 1987; 60:2621–2623
Brennan MF, Bloomer WD. Cancer of the endocrine system. In De Vita VT Jr, Hellman S, Rosenberg SA (eds): Cancer: Principles and Practice of Oncology. Philadelphia: Lippincott, 1982:971–973
Brincker H, Hansen HS, Andersen AP. Induction of leukemia by 131I treatment of thyroid carcinoma. Br J Cancer 1973;28:232–237
Buckwalter JA, Thomas CG, Freeman JB. Is childhood thyroid cancer a lethal disease? Ann Surg 1975;181:632–638
Cady B, Sedgwick CE, Meissner WA, et al. Changing clinical, pathologic, therapeutic, and survival patterns in differentiated thyroid carcinoma. Ann Surg 1976;184:541–552
Corstens F, Huysmans D, Kloppenborg P. Thallium-201 scintigraphy of the suppressed thyroid: an alternative for iodine-123 scanning after TSH stimulation. J Nucl Med 1988;29:1360–1363
Eisenberg BL, Hensley SD. Thyroid cancer with coexistent Hashimoto’s thyroiditis: clinical assessment and management. Arch Surg 1989; 124: 1045–1047
Emmertsen K. Medullary thyroid carcinoma and calcitonin. Dan Med Bull 1985;32:1–28
Favus MJ, Schneider AB, Stachura ME, et al. Thyroid cancer occurring as a late consequence of head-and-neck irradiation: evaluation of 1056 patients. N Engl J Med 1976;294:1019–1025
Fisher DA, Burrow GN, Dussault JH, et al. Recommendations for screening programs for congenital hypothyroidism: committee of the American Thyroid Association. J Pediatr 1976;89:692–694
Frankenthaler RA, Sellin RV, Cangir A, Goepfert H. Lymph node metastasis from papillary-follicular thyroid carcinoma in young patients. Am J Surg 1990;160:341–343
Fuks Z, Glatstein E, Marsa GW, Bagshaw MA, Kaplan HS. Long-term effects of external radiation on the pituitary and thyroid glands. Cancer 1976; 37:1152–1161
Gharib H, McConahey WM, Tiegs RD, et al. Medullary thyroid carcinoma: clinicopathologic features and long-term follow-up of 65 patients treated during 1946 through 1970. Mayo Clin Proc 1992; 67:934–940
Goepfert H, Dichtel WJ, Samaan NA. Thyroid cancer in children and teenagers. Arch Otolaryngol 1984; 110:72–75
Hamburger JI, Miller JM, Garcia M, et al. Is thyroid imaging an overutilized diagnostic procedure? In Hamburger JG, Miller JM (eds): Controversies in Clinical Thyroidology. New York: Springer 1981:1–20
Holm L-E, Blomgren H, Löwhagen T. Cancer risks in patients with chronic lymphocytic thyroiditis. N Engl JMed 1985;312:601–604
Hopwood NJ, Carroll RG, Kenny FM, Foley TP Jr. Functioning thyroid masses in childhood and adolescence: clinical, surgical, and pathologic correlations. J Pediatr 1976;89:701–708
Hung W, Anderson KD, Chandra RS, et al. Solitary thyroid nodules in 71 children and adolescents. J Pediatr Surg 1992;27:1407–1409
Kao CH, Lin WY, Wang SJ, Yeh SH. Visualization of suppressed thyroid tissue by Tc-99m MIBI. Clin Nucl Med 1991;16;812–814
Kay C, Abrahams S, McClain P. The weight of normal thyroid glands in children. Arch Pathol 1966; 82:349–352
Kirkland RT, Kirkland JL, Rosenberg HS, et al. Solitary thyroid nodules in 30 children and report of a child with a thyroid abscess. Pediatrics 1973; 51:85–90
Kusic Z, Becker DV, Saenger EL, et al. Comparison of technetium-99m and iodine-123 imaging of thyroid nodules: correlation with pathologic findings. J Nucl Med 1990;31:393–399
Maxon HR, Saenger EL, Thomas SR, et al. Clinically important radiation-associated thyroid disease: a controlled study. JAMA 1980;244:1802–1805
Maxon HR, Thomas SR, Hertzberg VS, et al. Relation between effective radiation dose and outcome of radioiodine therapy in thyroid cancer. N Engl JMed 1983;309:937–941
Mazzaferri EL, Young RL, Oertel JE, Kemmerer WT, Page CP. Papillary thyroid carcinoma: the impact of therapy in 576 patients. Medicine (Baltimore) 1977;56:171–196
Mochizuki Y, Mowafy R, Pasternack B. Weights of human thyroids in New York City. Health Phys 1963;9:1299–1301
Mueller S, Guth-Tougelides B, Creutzig H. Imaging of malignant tumors with Tc-99m-MIBI SPECT [abstract]. J Nucl Med 1989;30:845
NCRP Report No. 37. Precautions in the management of patients who have received therapeutic amounts of radionuclides. Washington, DC: NCRP Publications, 1973:6–23
Ochi H, Sawa H, Fukuda T, et al. Thallium-201-chloride thyroid scintigraphy to evaluate benign and/or malignant nodules: usefulness of the delayed scan. Cancer 1982;50:236–240
Ott RA, McCall AR, McHenry C, et al. The incidence of thyroid carcinoma in Hashimoto’s thyroiditis. Am Surg 1987;53:442–445
Paltiel HJ, Summerville DA, Treves ST. Iodine-123 scintigraphy in the evaluation of pediatric thyroid disorders: a ten year experience. Pediatr Radiol 1992;22:251–256
Pankow BG, Michalak J, McGee MK. Adult human thyroid weight. Health Phys 1985;49:1097–1103
Pincus RA, Reichlin S, Hempelmann LH. Thyroid abnormalities after radiation exposure in infancy. Ann Intern Med 1967;66:1154–1164
Pochin EE. The occurrence of leukaemia following radioiodine therapy. In Pitt-Rivers R (ed): Advances in Thyroid Research. New York: Pergamon Press, 1961;392–397
Rall JE, Alpers JB, Lewallen CG, et al. Radiation pneumonitis and fibrosis: a complication of radioiodine treatment of pulmonary metastases from cancer of the thyroid. J Clin Endocrinol 1957;17:1263–1276
Rallison ML, Dobyns BM, Keating FR, Rall JE, Tyler FH. Thyroid nodularity in children. JAMA 1975;233:1069–1072
Ramanathan P, Patel RB, Subrahmanyam N, et al. Visualization of suppressed thyroid tissue by tech-netium-99m-tertiary butyl isonitrile: an alternative to post-TSH stimulation scanning. J Nucl Med 1990;31:1163–1165
Reasner CA Jr, Reasner CA, Isley WL. Thyroid scanning in patients with suspected thyroid disease. Ann InternMed 1985;102:209–210
Ron E, Modan B, Preston D, et al. Thyroid neoplasia following low-dose radiation in childhood. Radiat Res 1989;120:516–531
Saad MF, Ordonez NG, Rashid RK, et al. Medullary carcinoma of the thyroid: a study of the clinical features and prognostic factors in 161 patients. Medicine (Baltimore) 1984;63:319–342
Safa AM, Schumacher OP. Follow-up of children treated with 1–131 [letter]. N Engl J Med 1976;294:54
Safa AM, Schumacher OP, Rodriguez-Antunez A. Long-term follow-up results in children and adolescents treated with radioactive iodine[131I] for hyperthyroidism. N Engl J Med 1975;292:167–171
Samaan NA, Maheshwari YK, Nader S, et al. Impact of therapy for differentiated carcinoma of the thyroid: an analysis of 706 cases. J Clin Endocrinol Metab 1983;56:1131–1138
Samaan NA, Schultz PN, Hickey RC. Medullary thyroid carcinoma: prognosis of familial versus sporadic disease and the role of radiotherapy. J Clin Endocrinol Metab 1988;67:801–805
Sampson RJ. Prevalance and significance of occult thyroid cancer. In DeGroot LJ (ed): Radiation-Associated Thyroid Carcinoma. Orlando, FL: Grune & Stratton, 1977:137–153
Sarkar SD, Beierwaltes WH, Gill SP, Cowley BJ. Subsequent fertility and birth histories of children and adolescents treated with 131–1 for thyroid cancer. J Nucl Med 1976;17:460–464
Schlumberger M, De Vathaire F, Travagli JP, et al. Differentiated thyroid carcinoma in childhood: long term follow-up of 72 patients. J Clin Endocrinol Metab 1987;65:1088–1094
Scott MD, Crawford JD. Solitary thyroid nodules in childhood: is the incidence of thyroid carcinoma declining? Pediatrics 1976;58:521–525
Silverman SH, Nussbaum M, Rausen AR. Thyroid nodules in children: a ten year experience at one institution. Mt Sinai J Med 1979;46:460–463
Sisson JC. Applying the radioactive eraser: 1–131 to ablate normal thyroid tissue in patients from whom thyroid cancer has been resected [editorial]. J Nucl Med 1983;24:743–745
Snyder J, Gorman C, Scanlon P. Thyroid remnant ablation: questionable pursuit of an ill-defined goal. J Nucl Med 1983;24:659–665
Surks MI, Chopra IJ, Mariash CN, Nicoloff JT, Solomon DH. American Thyroid Association guidelines for use of laboratory tests in thyroid disorders. JAMA 1990;263:1529–1532
Szabo SM, Allen DB. Thyroiditis: differentiation of acute suppurative and subacute; case report and review of the literature. Clin Pediatr 1989; 28:171–174
Tucker MA, Morris Jones PH, Boice JD Jr, et al. Therapeutic radiation at a young age is linked to secondary thyroid cancer. Cancer Res 1991;51: 2885–2888
Webster EW, Alpert NM, Brownell GL. Radiation doses in pediatric nuclear medicine and diagnostic x-ray procedures. In James AE, Wagner HN, Cooke RE (eds): Pediatric Nuclear Medicine. Philadelphia: Saunders, 1974:34–58
Wells SA Jr, Dilley WG, Farndon JA, Leight GS, Baylin SB. Early diagnosis and treatment of medullary thyroid carcinoma. Arch Intern Med 1985;145:1248–1252
Winship T, Rosvall RV. Thyroid carcinoma in childhood: final report on a 20 year study. Clin Proc Child Hosp Natl Med Cent 1970;26:327–348
Wolfstein RS. Enigma of the “hyperfunctioning” thyroid carcinoma resolved [letter]? J Nucl Med 1978;19:441–442
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Paltiel, H.J., Larsen, R., Treves, S.T. (1995). Thyroid. In: Treves, S.T. (eds) Pediatric Nuclear Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4205-3_9
Download citation
DOI: https://doi.org/10.1007/978-1-4757-4205-3_9
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4757-4207-7
Online ISBN: 978-1-4757-4205-3
eBook Packages: Springer Book Archive