• G. Wernovsky
  • R. A. Hurwitz
  • S. N. Weindling
  • A. Kuruc
  • S. T. Treves


Application of radionuclides to the study of the cardiovascular system was first investigated by Blumgart and Yens13 and by Blumgart and Weiss12 in 1927 when they used radium C and a primitive radiation detector in studies on the velocity of blood flow. In 1948 and 1949 Prinzmetal et al.99,100 described radiocardiograms of three patients with congenital heart disease using iodine-131 (131I), sodium iodide, and a Geiger-Mueller counter. With dramatic improvements in technology (radiopharmaceuticals and imaging instrumentation), nuclear medicine now offers a broad scope of methods applicable to the diagnosis and assessment of pediatric cardiac disorders: first-pass radionuclide angiocardiography, radionuclide ventriculography (gated blood pool scan), myocardial perfusion scintigraphy, venography, and pulmonary scintigraphy.


Myocardial Perfusion Kawasaki Disease Superior Vena Cava Great Artery Right Atrium 
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  1. 1.
    Agata Y, Hiraishi S. Hitoshi M, Takanashi S, Yashiro K. Two-dimensional echocardiography determinants of interventricular septal configurations in right or left ventricular overload. Am Heart J 1985;110:819–825PubMedCrossRefGoogle Scholar
  2. 2.
    Akagi T, Benson LN, Gilday DL, et al. Influence of ventricular morphology on diastolic filling performance in double-inlet ventricle after the Fontan procedure. J Am Coll Cardiol 1993;22:1948–1952PubMedCrossRefGoogle Scholar
  3. 3.
    Akagi T, Benson LN, Green M, et al. Ventricular performance before and after Fontan repair for uni-ventricular atrioventricular connection: angiographic and radionuclide assessment. J Am Coll Cardiol 1992;20:920–926PubMedCrossRefGoogle Scholar
  4. 4.
    Alderson PO, Douglass KH, Mendenhall KG, et al. Deconvolution analysis in radionuclide quantitation of left to right cardiac shunts. J Nucl Med 1979;20:502–506PubMedGoogle Scholar
  5. 5.
    Alderson PO, Gaudiani VA, Watson DC. Quantitation radionuclide angiocardiography in animals with experimental atrial septal defects. J Nucl Med 1978;19:364–369PubMedGoogle Scholar
  6. 6.
    Alderson PO, Jost RG, Strauss AW, Boonvisut S, Markham J. Detection and quantitation of left-to-right cardiac shunts in children: a clinical comparison of count ratio and area ratio techniques. J Nucl Med 1975;16:511Google Scholar
  7. 7.
    Arensman FW, Sievers H, Lange PE, et al. Assessment of coronary and aortic anastomoses after anatomic correction of transposition of the great arteries. J Thorac Cardiovasc Surg 1985; 90:597–604PubMedGoogle Scholar
  8. 8.
    Askenasi J, Ahnberg DS, Korngold E, et al. Quantitative radionuclide angiocardiograph: detection and quantitation of left-to-right shunts. Am J Cardiol 1976;37:382–387CrossRefGoogle Scholar
  9. 9.
    Baker EJ, Shubao C, Clarke S, et al. Radionuclide measurement of right ventricular function in atrial septal defect, ventricular septal defect and complete transposition of the great arteries. Am J Cardiol 1986;57:1142–1146PubMedCrossRefGoogle Scholar
  10. 10.
    Bassingthwaihte JB. Circulatory transport and the convolution integral. Mayo Clin Proc 1967; 42:137–154Google Scholar
  11. 11.
    Berman DS, Salel AF, De Nardo GL, Bogren GH, Mason DT. Clinical assessment of left ventricular regional contraction patterns and ejection fraction by high resolution gated scintigraphy. J Nucl Med 1975;16:865–874PubMedGoogle Scholar
  12. 12.
    Blumgart HL, Weiss S. Studies on the velocity of blood flow. VII. The pulmonary circulation time in normal resting individuals. J Clin Invest 1927; 4:399–425PubMedCrossRefGoogle Scholar
  13. 13.
    Blumgart HL, Yens OC. Studies on the velocity of blood flow. I. The method utilized. J Clin Invest 1927;4:1–13PubMedCrossRefGoogle Scholar
  14. 14.
    Borow KM, Keane JF, Castaneda AR, Freed MD. Systemic ventricular function in patients with tetralogy of Fallot, ventricular septal defect and transposition of the great arteries repaired during infancy. Circulation 1981;64:878–885PubMedCrossRefGoogle Scholar
  15. 15.
    Bosnjakovic VB, Bennett LR. Dynamic isotope studies in cardiology. AEC Symp Series 1972; 27:562Google Scholar
  16. 16.
    Bough EW, Gandsman EF, North DL, Shulman RS. Gated radionuclide angiographic evaluation of valve regurgitation. Am J Cardiol 1980;46:423–428PubMedCrossRefGoogle Scholar
  17. 17.
    Bourguignon MH, Links JM, Douglass KH, et al. Quantitation of left-to-right shunts by multiple deconvolution analysis. Am J Cardiol 1981; 48:1086–1092PubMedCrossRefGoogle Scholar
  18. 18.
    Braunwald E, Long RTL, Morrow AG. Injections of radioactive krypton (Kr85) solutions in the detection of cardiac shunts. J Clin Invest 1959;38:990Google Scholar
  19. 19.
    Bull C, DeLeval MR, Mercanti C, Macartney FJ, Anderson RH. Pulmonary atresia and intact ventricular septum: a revised classification. Circulation 1982;66:266–272PubMedCrossRefGoogle Scholar
  20. 20.
    Bunton R, Jonas RA, Lang P, Rein AJJT, Castaneda AR. Anomalous origin of left coronary artery from pulmonary artery. J Thorac Cardiovasc Surg 1987;93:103–108PubMedGoogle Scholar
  21. 21.
    Caplin JL, Dymond DS, O’Keefe JC, et al. Relation between exercise: a study using first-pass radionuclide angiography with gold-195m. Br Heart J 1986;55:120–128PubMedCrossRefGoogle Scholar
  22. 22.
    Castaneda AR, Mayer JE, Jonas RA. The neonate with critical congenital heart disease: repair—a surgical challenge. J Thorac Cardiovasc Surg 1989;98:869PubMedGoogle Scholar
  23. 23.
    Castaneda AR, Mayer JE Jr, Jonas RA, Wernovsky G, Di Donato RM. Transposition of the great arteries: the arterial switch operation. Cardiol Clin 1989;7:369–376PubMedGoogle Scholar
  24. 24.
    Chang AC, Hanley FL, Lock JE, Wessel DL, Castaneda AR. Management and outcome of low birth weight neonates with congenital heart disease. Pediatrics 1993 (in press)Google Scholar
  25. 25.
    Cohen HA, Baird MG, Rouleau JR, et al. Thallium 201 myocardial imaging in patients with pulmonary hypertension. Circulation 1976;54:790–795PubMedCrossRefGoogle Scholar
  26. 26.
    Colan SD, Borow KM, Neumann A. Left ventricular end-systolic wall stress-velocity of fiber shortening relation: a load-independent index of myocardial contractility. J Am Coll Cardiol 1984;4:715–724PubMedCrossRefGoogle Scholar
  27. 27.
    Day RW, Laks H, Drinkwater DC. The influence of coronary anatomy on the arterial switch operation in neonates. J Thorac Cardiovasc Surg 1992; 104: 706–712PubMedGoogle Scholar
  28. 28.
    De Levai MR, Kilner P, Gewillig M, Bull C. Total cavopulmonary connection: a logical alternative to atriopulmonary connection for complex Fontan operations. J Thorac Cardiovasc Surg 1988; 96:682–695Google Scholar
  29. 29.
    Del Torso S, Milanesi O, Bui F, et al. Radionuclide evaluation of lung perfusion after the Fontan procedure. Int J Cardiol 1988;20:107–116PubMedCrossRefGoogle Scholar
  30. 30.
    Driscoll DJ, Hesslein PS, Mullins CE. Congenital stenosis of individual pulmonary veins: clinical spectrum and unsuccessful treatment by transve-nous balloon dilation. Am J Cardiol 1982; 49:1767–1772PubMedCrossRefGoogle Scholar
  31. 31.
    Flynn B, Wernovsky G, Summerville DA, Castaneda AR, Treves ST. Comparison of tech-netium-99m MIBI and thallium-201 chloride myocardial scintigraphy in infants. J Nucl Med 1989;30:1176–1181PubMedGoogle Scholar
  32. 32.
    Fontan F, Kirklin JW, Fernandez G, et al. Outcome after a “perfect” Fontan operation. Circulation 1990;81:1520–1536PubMedCrossRefGoogle Scholar
  33. 33.
    Franken PR, Dobbeleir AA, Ham HR, et al. Clinical usefulness of ultrashort-lived tiridium-191 from a carbon based generator system for the evaluation of left ventricular function. J Nucl Med 1989; 30:1025–1031PubMedGoogle Scholar
  34. 34.
    Fyler DC. Report of the New England Regional Infant Cardiac Program. Pediatrics 1980;65 (suppl):377Google Scholar
  35. 35.
    Gamel J, Rousseau WF, Katholi CR, Mesel E. Pitfalls in digital computation of the impulse response of vascular beds from indicator-dilution. Circ Res 1973;32:516–523PubMedCrossRefGoogle Scholar
  36. 36.
    Gates GF, Orme HW, Dore EK. Measurement of cardiac shunting with technetium labeled albumin aggregates. J Nucl Med 1971;12:746–749PubMedGoogle Scholar
  37. 37.
    Gehring PJ, Hammond PB. The interrelationship between thallium and potassium in animals. J Pharmacol Exp Ther 1967;155:187–201PubMedGoogle Scholar
  38. 38.
    Gentles TL, Colan SD, Giglia TM, et al. Right ventricular decompression and left ventricular function in pulmonary atresia with intact ventricular septum: the influence of less extensive coronary anomalies. Circulation 1993;88:183–188Google Scholar
  39. 39.
    Gentles TL, Lock JE, Perry SB. High pressure balloon angioplasty for branch pulmonary artery stenosis; early experience. J Am Coll Cardiol 1993; 22:867–872PubMedCrossRefGoogle Scholar
  40. 40.
    Giglia TM, Mandell VS, Connor AR, Mayer JE Jr, Lock JE. Diagnosis and management of right ventricle-dependent coronary circulation in pulmonary atresia with intact ventricular septum. Circulation 1922;86:1516–1628CrossRefGoogle Scholar
  41. 41.
    Goor DA, Shem-Tov A, Neufeld HN. Impeded coronary flow in anatomic correction of transposition of the great arteries: prevention, detection, and management. J Thorac Cardiovasc Surg 1982;83: 747–754PubMedGoogle Scholar
  42. 42.
    Graham TP Jr, Jarmakani JM, Canent RV Jr, Norrow MN. Left heart volume estimation in infancy and childhood: reevaluation of methodology and normal values. Circulation 1971;43:895–904PubMedCrossRefGoogle Scholar
  43. 43.
    Ham HR, Dobbeleir A, Viart P, Piepz A, Lenaers A. Radionuclide quantitation of left-to-right cardiac shunts using deconvolution analysis: concise communication. J Nucl Med 1981 ;22:688–692PubMedGoogle Scholar
  44. 44.
    Hanely FL, Sade RM, Blackstone EH, et al. Outcomes in neonatal pulmonary atresia with intact ventricular septum—a multiinstitutional study. J Thorac Cardiovasc Surg 1993;105:406–427Google Scholar
  45. 45.
    Hegge FN, Hamilton GW, Larson SM, Ritchie JL, Richards P. Cardiac chamber imaging: a comparison of red blood cells labeled with Tc-99m in vitro and in vivo. J Nucl Med 1978; 19:129–134PubMedGoogle Scholar
  46. 46.
    Heller GV, Treves ST, Parker JA, et al. Comparison of ultrashort-lived iridium-191m with technetium-99m for first pass radionuclide angiocardiographic evaluation of right and left ventricular function in adults. J Am Coll Cardiol 1982;7:1295–1302CrossRefGoogle Scholar
  47. 47.
    Hellman C, Zafrir N, Shimoni A, et al. Evaluation of ventricular function with first-pass iridium-191m radionuclide angiography. J Nucl Med 1989; 30:450–457PubMedGoogle Scholar
  48. 48.
    Hurley PJ, Poulose KP, Wagner HN Jr. Radionuclide angiocardiography for detecting right-to-left intracardiac shunts [abstract]. J Nucl Med 1969; 10:344Google Scholar
  49. 49.
    Hurwitz RA, Caldwell RL, Girod DA, et al. Ventricular function in transposition of the great arteries: evaluation by radionuclide angiocardiography. Am Heart J 1985;110:600–604PubMedCrossRefGoogle Scholar
  50. 50.
    Hurwitz RA, Randall LC, Girod DA, Brown J, King H. Clinical and hemodynamic course of infants and children with anomalous left coronary artery. Am Heart J 1989;118:1176–1181PubMedCrossRefGoogle Scholar
  51. 51.
    Hurwitz RA, Siddiqui A, Caldwell RL, Weetman RM, Girod DA. Assessment of ventricular function in infants and children: response to dobutamine infusion. Clin Nucl Med 1990;15:556–559PubMedCrossRefGoogle Scholar
  52. 52.
    Hurwitz RA, Treves S, Keane JF, Girod DA, Caldwell RL. Current value of radionuclide angiocardiography for shunt quantification and management in patients with secundum atrial septal defect. AmHeart J 1982;103:421–125Google Scholar
  53. 53.
    Hurwitz RA, Treves S, Kuruc A. Right ventricular and left ventricular ejection fraction in pediatric patients with normal hearts: first-pass radionuclide angiocardiography. Am Heart J 1984; 107:726–732PubMedCrossRefGoogle Scholar
  54. 54.
    Jatene AD, Fontes VF, Souza LCB, et al. Anatomic correction of transposition of the great arteries. J Thorac Cardiovasc Surg 1982;83:20–26PubMedGoogle Scholar
  55. 55.
    Kawana N, Krizeh H, Porter J,et al. UseofTl-201 as a potassium analog in scanning [abstract]. J Nucl Med 1970; 11:333Google Scholar
  56. 56.
    Khaja F, Alam M, Goldstein S, Anbe DT, Marks DS. Diagnostic value of visualization of the right ventricle using thallium-201 myocardial imaging. Circulation 1979;59:182–188PubMedCrossRefGoogle Scholar
  57. 57.
    Kipper SL, Ashburn WL, Norris SL, Rimkus DS, Dillon WA. Gold-195m first-pass radionuclide ventriculography, thallium-201 single-photon emission CT, and 12-lead ECG stress testing as a combined procedure. Radiology 1985;156:817–821PubMedGoogle Scholar
  58. 58.
    Kondo C, Hiroe M, Nakanishi T, Takao A. Detection of coronary artery stenosis in children with Kawasaki disease: usefulness of pharmacologic stress 201T1 myocardial tomography [abstract]. Circulation 1989;80:615–624PubMedCrossRefGoogle Scholar
  59. 59.
    Kondo C., Nakanishi T, Sonobe T, et al. Scintigraphic monitoring of coronary artery occlusion due to Kawasaki disease. Am J Cardiol 1993;71:681–685PubMedCrossRefGoogle Scholar
  60. 60.
    Kondo M. Thallium-201 myocardial imaging in patients with various heart diseases. Nippon Igaku Hoshasen Gakkai Zasshi 1979;39:942–945PubMedGoogle Scholar
  61. 61.
    Kondo M, Kubo A, Yamazaki H, et al. Thallium-201 myocardial imaging for evaluation of right ventricular overloading. J Nucl Med 1978; 19:1197–1203Google Scholar
  62. 62.
    Kurtz D, Ahnberg DS, Freed M, LaFarge CG, Treves S. Quantitative radionuclide angiocardiography: determination of left ventricular ejection fraction in children. Br Heart J 1976;38:966–973PubMedCrossRefGoogle Scholar
  63. 63.
    Kuruc A, Treves S, Parker JA. Accuracy of deconvolution algorithm assessed by simulation studies: concise communication. J Nucl Med 1983; 24:258–263PubMedGoogle Scholar
  64. 64.
    Kuruc A, Treves S, Parker JA, Cheng C, Sawan A. An improved deconvolution technique for correcting radionuclide angiography for suboptimal bolus injection: experimental results in dogs with and without atrial septal defects. Radiology 1983; 148:233–238PubMedGoogle Scholar
  65. 65.
    Kuruc A, Treves S, Smith W, Fujii A. An automated algorithm for the radionuclide quantitation of circulatory shunting. Comp Biomed Res 1984; 17: 481–493CrossRefGoogle Scholar
  66. 66.
    Kveder M, Bajzer Z, Nosil J. A mathematical model for the quantitative study of left to right cardiac shunts. Phys Med Biol 1985;30:207–215PubMedCrossRefGoogle Scholar
  67. 67.
    Kveder M, Bajzer Z, Zadro M. Theoretical aspects of multiple deconvolution analysis for quantification of left to right cardiac shunts. Phys Med Biol 1987;32:1237–1243PubMedCrossRefGoogle Scholar
  68. 68.
    Lacy JL, Layne WW, Guidry GW, Verani MS, Roberts R. Developmental and clinical performance of an automated, portable tungsten-178/tantalum-178 generator. J Nucl Med 1991;32:2158–2161PubMedGoogle Scholar
  69. 69.
    Lacy JL, Verani MS, Ball ME, et al. First-pass radionuclide angiography using a multiwire gamma camera and tantalum-178. J Nucl Med 1988; 29:293–301PubMedGoogle Scholar
  70. 70.
    Lacy JL, Verani MS, Ball ME, Robert R. Clinical applications of a pressurized xenon wire chamber gamma camera utilizing the short lived agent 178Ta. Nucl Inst Meth 1988;A269:369–376Google Scholar
  71. 71.
    Lahiri A, Zanelli GD, O’Hara MJ, et al. Simultaneous measurement of left ventricular function and myocardial perfusion during a single exercise test: dual isotope imaging with gold-195 and thallium-201. Eur Heart J 1986;7:493–500PubMedGoogle Scholar
  72. 72.
    Lam W, Pavel D, Byron E, et al. Radionuclide regurgitant index: value and limitations. Am J Cardiol 1981;47:292–298PubMedCrossRefGoogle Scholar
  73. 73.
    Lebowitz E, Green MW, Fairchild R, et al. Thallium-201 for medical use I. J Nucl Med 1975;16:151–155PubMedGoogle Scholar
  74. 74.
    Liberthson RR, Pohost GM, Dinsmore RE. Atrial septal defect: pre-and postoperative evaluation by gated cardiac scanning [abstract]. J Nucl Med 1979;19:750Google Scholar
  75. 75.
    Lin CY. Lung scan in cardiopulmonary disease. I. Tetralogy of Fallot. J Thorac Cardiovasc Surg 1971;61:370–379PubMedGoogle Scholar
  76. 76.
    Long RTL, Braunwald E, Morrow AG. Intracardiac injection of radioactive krypton: clinical applications of new methods for characterization of circulatory shunts. Circulation 1960;21:1126–1133PubMedCrossRefGoogle Scholar
  77. 77.
    Long RTL, Waldhausen JA, Cornell WP, Sanders RJ. Detection of right-to-left circulatory shunts: a new method utilizing injections of krypton85. Proc Soc Exp Biol Med 1959;102:456–458PubMedGoogle Scholar
  78. 78.
    Louie EK, Rich S, Brundage BH. Doppler echocar-diographic assessment of impaired left ventricular filling in patients with right ventricular pressure overload due to primary pulmonary hypertension. J Am Coll Cardiol 1986;8:1298–1306PubMedCrossRefGoogle Scholar
  79. 79.
    Madsen MT, Argenyi E, Preslar J, Grover-McKay M, Kirchner PT. An improved method for the quantification of left-to-right cardiac shunts. J Nucl Med 1991;32:1808–1812PubMedGoogle Scholar
  80. 80.
    Magrina J, Bosch X, Garcia A. Diagnostic value of technetium-99m-MIBI as a myocardial perfusion imaging agent: comparison of long and short intervals between rest and stress injections. Clin Cardiol 1992;15:497–503PubMedCrossRefGoogle Scholar
  81. 81.
    Mair DD, Hagler DJ, Julsrud PR, et al. Early and late results of the modified Fontan procedure for double-inlet left ventricle: the Mayo Clinic experience. J Am Coll Cardiol 1991;18:1727–1732PubMedCrossRefGoogle Scholar
  82. 82.
    Maltz DL, Treves S. Quantitative radionuclide angiocardiography: determination of QpQs in children. Circulation 1973;47:1049–1056PubMedCrossRefGoogle Scholar
  83. 83.
    Martine M, Stanley P, Chartrand C, et al. Postoperative evaluation after end-to-end subcla-vian-left coronary artery anastomosis in anomalous left coronary artery. J Thorac Cardiovasc Surg 1990;100:270–273Google Scholar
  84. 84.
    Mayer JE Jr, Jonas RA, Castaneda AR. Arterial switch operation for transposition of the great arteries with intact ventricular septum. J Cardiac Surg 1986;1:97–104CrossRefGoogle Scholar
  85. 85.
    Mayer JE Jr, Sanders SP, Jonas RA, Castaneda AR, Wernovsky G. Coronary artery pattern and outcome of arterial switch operation for transposition of the great arteries. Circulation 1990;82(suppl IV): 139–145Google Scholar
  86. 86.
    Miller DD, Gill JB, Fischman AJ, et al. New radionuclides for cardiac imaging. Prog Cardiovasc Dis 1986;28:419–434PubMedCrossRefGoogle Scholar
  87. 87.
    Nakamura M, Suzuki Y, Nagasawa T, Sugehara M, Takahashi T. Detection and quantitation of left-to-right shunts from radionuclide angiocardiography using the homomorphic deconvolution technique. IEEE Trans Biomed Eng 1982;29:192–201PubMedCrossRefGoogle Scholar
  88. 88.
    Nakanishi T, Takao A, Kondo C, et al. ECG findings after myocardial infarction in children after Kawasaki disease [abstract]. Am Heart J 1988;116:1028–1033PubMedCrossRefGoogle Scholar
  89. 89.
    Nienaber CA, Speilmann RP, Hausdorf G. Dipyridamole-thallium-201 tomography documenting improved myocardial perfusion with therapy in Kawasaki disease [abstract]. Am Heart J 1988;116:1575–1579PubMedCrossRefGoogle Scholar
  90. 90.
    O’Laughlin MP, Perry SB, Lock JE, Mullins CE. Use of endovascular stents in congenital heart disease. Circulation 1991;83:1923–1939PubMedCrossRefGoogle Scholar
  91. 91.
    O’Laughlin MP, Slack MC, Grifka RG, et al. Implantation and intermediate-term follow-up of stents in congenital heart disease. Circulation 1993;88:605–614PubMedCrossRefGoogle Scholar
  92. 92.
    Paras T, Thiessen JW. Single-photon ultrashort-lived radionuclides. USDOE Symp Ser 1985;57Google Scholar
  93. 93.
    Parikh SR, Hurwitz RA, Caldwell RL, Girod DA. Ventricular function in the single ventricle before and after Fontan surgery. Am J Cardiol 1991; 67:1390–1395PubMedCrossRefGoogle Scholar
  94. 94.
    Parker JA, Secker-Walker R, Hill R, Siegel BA, Potchen EJ. A new technique for the calculation of left ventricular ejection fraction. J Nucl Med 1972;13:649–651PubMedGoogle Scholar
  95. 95.
    Parker JA, Treves S. Radionuclide detection localization and quantitation of intracardiac shunts and shunts between the great arteries. Prog Cardiovasc Dis 1977;20:121–150PubMedCrossRefGoogle Scholar
  96. 96.
    Parrish MD, Graham TP, Bender HW, et al. Radionuclide angiographic evaluation of right and left ventricular function during exercise after repair of transposition of the great arteries. Circulation 1983;67:178–183PubMedCrossRefGoogle Scholar
  97. 97.
    Pavel DG, Zimmer AM, Patterson VN. In vivo labelling of red cells with Tc-99m: a new approach to blood pool visualization. J Nucl Med 1977; 18:305–308PubMedGoogle Scholar
  98. 98.
    Pohost GM, Fallon JT, Strauss HW. Radionuclide techniques in cardiomyopathy. In Strauss HW, Pitt B (eds): Cardiovascular Nuclear Medicine (2nd ed.) St. Louis: Mosby, 1979Google Scholar
  99. 99.
    Prinzmetal M, Corday E, Bergman HC, Schwartz L, Spritzler RJ. Radiocardiography: a new method for studying the blood flow through the chambers of the heart in human beings. Science 1948;108:340–341PubMedCrossRefGoogle Scholar
  100. 100.
    Prinzmetal M, Corday E, Spritzler RJ, Flieg W Radiocardiography and its clinical applications. JAMA 1949;149:617–622CrossRefGoogle Scholar
  101. 101.
    Rabinovitch M, Fischer KC, Gamble W, Reid L, Treves S. Thallium-201: quantitation of right ventricular hypertrophy in chronically hypoxic rats. Radiology 1979;130:223–225PubMedGoogle Scholar
  102. 102.
    Rabinovitch M, Fischer KC, Treves S. Quantitative thallium-201 myocardial imaging in assessment of right ventricular pressure in patients with congenital heart defects. Br Heart J 1981 ;45:198–205PubMedCrossRefGoogle Scholar
  103. 103.
    Rees S, Somerville J, Warnes CA, et al. Comparison of magnetic resonance imaging with echocardiography and radionuclide angiography in assessing cardiac function and anatomy following Mustard’s operation for transposition of the great arteries. Am JCardiol 1988;61:1316–1322CrossRefGoogle Scholar
  104. 104.
    Rein AJJT, Colan SD, Parness IA, Sanders SP. Regional and global left ventricular function in infants with anomalous origin of the left coronary artery from the pulmonary trunk: preoperative and postoperative assessment. Circulation 1987;75: 115–123PubMedCrossRefGoogle Scholar
  105. 105.
    Rigo P, Alderson PO, Robertson RM, Becker LC, Wagner HN. Measurement of aortic and mitral regurgitation by gated cardiac pool scans. Circulation 1979;60:306–312PubMedCrossRefGoogle Scholar
  106. 106.
    Riihimaki E, Heiskanen A, Tahti E. Theory of quantitative determination of intracardiac shunts by external detection. Ann Clin Res 1974;6:45–49PubMedGoogle Scholar
  107. 107.
    Rothman A, Perry SB, Keane JF, Lock JE. Balloon dilation of branch pulmonary artery stenosis. Semin Thorac Cardiovasc Surg 1990;2:46–54PubMedGoogle Scholar
  108. 108.
    Rothman A, Perry SB, Keane JF, Lock JE. Early results and follow-up of balloon angioplasty for branch pulmonary artery stenoses. J Am Coll Cardiol 1990;15:1109–1117PubMedCrossRefGoogle Scholar
  109. 109.
    Sanders SP. Echocardiography and related techniques in the diagnosis of congenital heart defects. III. Conotruncus and great arteries. Echocardiography 1984; 1:443–493CrossRefGoogle Scholar
  110. 110.
    Sauer U, Stern H, Meisner H, Buhlmeyer K, Sebening F. Risk factors for perioperative mortality in children with anomalous origin of the left coronary artery from the pulmonary artery. J Thorac Cardiovasc Surg 1992;104:696–705PubMedGoogle Scholar
  111. 111.
    Sholler GF, Colan SD, Sanders SP. Effect of isolated right ventricular outflow obstruction on left ventricular function in infants. Am J Cardiol 1988; 62:778–784PubMedCrossRefGoogle Scholar
  112. 112.
    Sluysmans T, Sanders SP, van der Veide M, et al. Natural history and patterns of recovery of contractile function in single left ventricle after Fontan operation. Cardiovasc Intervent Radiol 1992; 86:1753–1761Google Scholar
  113. 113.
    Sorenson SG, O’Rourke RA, Chaudhuri TK. Noninvasive quantitation of valvar regurgitation by gated equilibrium radionuclide angiography. Circulation 1980;62:1089–1098CrossRefGoogle Scholar
  114. 114.
    Starmer CF, Clark DO. Computer computation of cardiac output using the gamma function. J Appl Physiol 1970;28:216–220Google Scholar
  115. 115.
    Stevens RM, Baird MG, Fuhrmann CF, et al. Detection of right ventricular hypertrophy by thallium 201 myocardial perfusion imaging [abstract]. Circulation 1975;51/52 (suppl II):243Google Scholar
  116. 116.
    Steward JA, Silimperi D, Harris P, et al. Echocardiographic documentation of vegetative lesions in infective endocarditis: clinical implications. Circulation 1980;61:374–380CrossRefGoogle Scholar
  117. 117.
    Stone DL, Barber RW, Ormerod OJ, Petch MC, Wraight EP. Quantification of intracardiac shunts by gold-195m, a new radionuclide with a short half life. Br Heart J 1985;54:495–500PubMedCrossRefGoogle Scholar
  118. 118.
    Strauer BE, Burger S, Bull U. Multifactorial determination of thallium-201 uptake of the heart: an experimental study concerning the influence of ventricular mass, perfusion and oxygen consumption. Basic Res Cardiol 1978;73:298–306PubMedCrossRefGoogle Scholar
  119. 119.
    Strauss HW, Harrison K, Tanjan JK, Lebowitz E, Pitt B. Thallium-201 for myocardial imaging. Circulation 1975;51:641–645PubMedCrossRefGoogle Scholar
  120. 120.
    Strauss HW, Zaret BL, Hurley PH, Natarajan TK, Pitt B. A scintiphotographic method for measuring left ventricular ejection fraction in man without cardiac catheterization. Am J Cardiol 1971;28: 575–580PubMedCrossRefGoogle Scholar
  121. 121.
    Striner H, Buell U, Kleinhans E, Bares R, Grosse W. Myocardial kinetics of 99mTc hexakis-(2-methoxy-isobutyl-isonitrile) (HMIBI) in patients with coronary heart disease: a comparative study versus TI-201 with SPECT. Nucl Med Commun 1988;9:15–23Google Scholar
  122. 122.
    Suzuki A, Kamiya T, Ono Y, Okuno M, Yagihara T. Aortocoronary bypass surgery for coronary arterial lesions resulting from Kawasaki disease [abstract]. J Pediatr 1990;116:567–573PubMedCrossRefGoogle Scholar
  123. 123.
    Tamir A, Melloul M, Berant M, et al. Lung perfusion scans in patients with congenital heart defects. J Am Coll Cardiol 1992;19:383–388PubMedCrossRefGoogle Scholar
  124. 124.
    Tatara K, Kusakawa S, Itoh K, et al. Collateral circulation in Kawasaki disease with coronary occlusion or severe stenosis [abstract]. Am Heart J 1991;121:797–802PubMedCrossRefGoogle Scholar
  125. 125.
    Treves S. Detection and quantitation of cardiovascular shunts with commonly available radionuclides. Semin Nucl Med 1980;10:16–26PubMedCrossRefGoogle Scholar
  126. 126.
    Treves S, Cheng C, Samuel A, Fujii A, Lambrecht R. Detection and quantitation of left-right shunting by iridium-191m angiography. In Medical Radionuclide Imaging (2nd ed). Vienna: IAEA, 1981:231–241Google Scholar
  127. 127.
    Treves S, Cheng C, Samuel A, et al. Iridium-191m angiocardiography for the detection and quantitation of left-to-right shunting. J Nucl Med 1980;21:1151–1157PubMedGoogle Scholar
  128. 128.
    Treves S, Fyler D., Fujii A. Low radiation radionuclide angiography: detection and quantitation of left-to-right shunts. JPediatr 1982;101:210–213CrossRefGoogle Scholar
  129. 129.
    Treves S, Maltz DL. Radionuclide angiocardiography. Postgrad Med 1974;56:99–197PubMedGoogle Scholar
  130. 130.
    Treves S, Maltz DL., Adelstein SJ. Intracardiac shunts. In James AE, Wagner HN Jr, Cooke RE (eds). Pediatric Nuclear Medicine. Philadelphia: Saunders, 1974Google Scholar
  131. 131.
    Treves ST, Newburger JW, Hurwitz RA. Radionuclide angiocardiography in children. J Am Coll Cardiol 1985;5:120S-127SPubMedCrossRefGoogle Scholar
  132. 132.
    Trowitzsch E, Colan SD, Sanders SP. Two-dimensional echocardiographic estimation of right ventricular area change and ejection fraction in infants with systemic right ventricle (transposition of the great arteries or hypoplastic left heart syndrome). Am J Cardiol 1985;55:1153–1157PubMedCrossRefGoogle Scholar
  133. 133.
    Tsuda E, Imakita M, Yagihara T, et al. Late death after arterial switch operation for transposition of the great arteries. Am Heart J 1992; 124:1551–1557PubMedCrossRefGoogle Scholar
  134. 134.
    Urquhart J, Patterson RE, Pacer M, et al. Quantitation of valve regurgitation by radionuclide angiography before and after valve replacement. Am JCardiol 1981;47:287–291CrossRefGoogle Scholar
  135. 135.
    Van der Wall EE, van Lingen A, den Hollander W, et al. Short-lived 95mAu for evaluation of left ventricular function by first-pass radionuclide angiography. Nuclearmedizin 1985;21:191–192Google Scholar
  136. 136.
    Verani MS, Guidry GW, Mahmarian JJ, et al. Effects of acute, transient coronary occlusion on global and regional right ventricular function in humans. J Am Coll Cardiol 1992;20:1490–1497PubMedCrossRefGoogle Scholar
  137. 137.
    Verani MS, Lacy JL, Ball ME, et al. Simultaneous assessment of regional ventricular function and perfusion utilizing iridium-191m and thallium-201 during a single exercise test. Am J Cardiol Imag 1988;2:206–213Google Scholar
  138. 138.
    Verani MS, Lacy JL, Guidry GW, et al. Quantification of left ventricular performance during transient coronary occlusion at various anatomic sites in humans: a study using tantalum-178 and a multiwire gamma camera. J Am Coll Cardiol 1992;19:297–306PubMedCrossRefGoogle Scholar
  139. 139.
    Vogel M, Ash J, Rowe RD, Trusler GA, Rabinovitch M. Congenital unilateral pulmonary vein stenosis complicating transposition of the great arteries. Am JCardiol 1984;54:166–171CrossRefGoogle Scholar
  140. 140.
    Vogel M, Smallhorn JF, Gilday D, et al. Assessment of myocardial perfusion in patients after the arterial switch operation. J Nucl Med 1991;32:237–241PubMedGoogle Scholar
  141. 141.
    Vogel M, Smallhorn JF, Trusler GA, Freedom RM. Echocardiographic analysis of regional left ventricular wall motion in children after the arterial switch operation for complete transposition of the great arteries. J Am Coll Cardiol 1990;15:1417–1423PubMedCrossRefGoogle Scholar
  142. 142.
    Vouhe PR, Tamisier D, Sidi D, et al. Anomalous left coronary artery from the pulmonary artery: results of isolated aortic reimplantation. Ann Thorac Surg 1992;54:621–627PubMedCrossRefGoogle Scholar
  143. 143.
    Weber PM, Dos Remedios LV, Jasko IA. Quantitative radioisotopic angiocardiography. J Nucl Med 1972;13:815–822PubMedGoogle Scholar
  144. 144.
    Weindling SN, Wernovsky G, Colan SD, et al. Myocardial perfusion, function and exercise tolerance after the arterial switch operation. J Am Coll Cardiol 1994; 19:219AGoogle Scholar
  145. 145.
    Yano Y, Anger HO. Ultrashort-lived radioisotopes for visualizing blood vessels and organs. J Nucl Med 1968;9:1–6Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • G. Wernovsky
  • R. A. Hurwitz
  • S. N. Weindling
  • A. Kuruc
  • S. T. Treves

There are no affiliations available

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