Abstract
Nuclear medicine offers imaging methods to assess regional pulmonary blood flow and ventilation, gas and fluid transport across the alveolar-capillary membrane, mucociliary clearance, pulmonary aspiration, and parenchymal diseases.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Alavi A. Scintigraphic demonstration of acute gastrointestinal bleeding. Gastorintest Radiol 1980; 5:205–208
Alavi A, Dann RW, Baum S, Biery DN. Scintigraphic detection of acute gastrointestinal bleeding. Radiology 1977;124:753–756
Alberts C, Van Der Schoot J, Van Datselaar J, Braat M, Roos CM. GA-67 scintigraphy, serum lysozyme and angiotensin-converting enzyme in pulmonary sarcoidosis. Eur J Respir Dis 1983;64:38–46
Alderson PO, Secker WR, Strominger DB, et al. Quantitative assessment of regional ventilation and perfusion in children with cystic fibrosis. Radiology 1974;111:151–155
Amis TC, Crawford AB, Davison A, Engel LA. Distribution of inhaled 99m technetium labelled ultrafine carbon particle aerosol (Technegas) in human lungs. Eur Respir J 1990;3:679–685
Arborelius M. Influence of moderate hypoxemia in one lung on the distribution of the pulmonary circulation and ventilation. Scand J Clin Lab Invest 1965;17:257–259
Baghdassarian OM, Avery ME, Neuhauser E. A form of pulmonary insufficiency in premature infants: pulmonary dismaturity? AJR 1963;89: 1020–1031
Barry J, Alazraki NP, Heaphy JH. Scintigraphic detection of intrapulmonary bleeding using TC-99m sulfur colloid. J Nucl Med 1981 ;22:777–780
Bateman J, Newman SP, Daunt KM, Pavia D, Clarke SW. Regional lung clearance of excessive bronchial secretions during chest physiotherapy in patients with stable chronic airways obstruction. Lancet 1979,294–297
Bates DV, Macklem PT, Christie RV. Respiratory function in disease. In: An Introduction to the Integrated Study of the Lung. Philadelphia: Saunders, 1971
Bell WR, Simon TL. Current status of pulmonary thromboembolic disease: pathophysiology, diagnosis, prevention and treatment. Am Heart J 1982;103:239–262
Bell WR, Simon TL, DeMets DL. The clinical features of submassive and massive pulmonary emboli. Am J Med 1977;62:355–360
Bentivoglio LG, Beerel F, Bryan AC, et al. Regional pulmonary function studied with xenon-133 in patients with bronchial asthma. J Clin Invest 1963;42:1193–1200
Bohm N, Keller KM, Kloke WD. Pulmonary and systemic cerebellar tissue embolism due to birth injury. Virchows Arch [Pathol Anat] 1982;398: 229–235
Buchanan D, Mason JK. Occurrence of pulmonary fat and bone marrow embolism. Am J Forensic Med Pathol 1982;3:73–78
Buck JR, Connors RH, Coon WW, et al. Pulmonary embolism in children. J Pediatr Surg 1981; 16:385–391
Burch WM, Sullivan PJ, Lomas FE, et al. Lung ventilation studies with technetium-99m pseudogas. J Nucl Med 1986;27:842–846
Burch WM, Sullivan PJ, McLaren CJ. Technegas: a new ventilation agent for lung scanning. Nucl Med Commun 1986;7:865–871
Chandler AB. The anatomy of a thrombus. In Sherry SBK, Genton E, Stengle JM (eds): Thrombus. Washington, DC: National Academy of Science, 1969.
Chen J, Robinson AE, Goodrich JK. Uneven distribution of pulmonary blood flow between left and right lungs in isolated valvular pulmonic stenosis. AJR 1969;107:343–350
Coates G, O’Brodovich H. Extrapulmonary radioactivity in lung permeability measurements. J Nucl Med 1987;28:903–906
Coates G, O’Brodovich H. Measurement of pulmonary epithelial permeability with 99mTc -DTPA aerosol. Sem in NuclMed 1986;16:275–284
Coel NM, Durger G. Radionuclide detection of the site of hemoptysis. Chest 1982;81:242–243
Cone RB. A review of Boeck’s sarcoid with analysis of twelve cases occurring in children. J Pediatr 1948;32:629–640
Cook G, Clarke SE. An evaluation of Technegas as a ventilation agent compared with krypton-8 lm in the scintigraphic diagnosis of pulmonary embolism. Eur J Nucl Med 1992;19:770–774
Coon WW. Risk factors in pulmonary embolism in childhood. Surg Gynecol Obstet 1976;143:385–390
Cummings GR, MacPherson RI, Chernick V. Unilateral hyperlucent lung syndrome in children. J Pediatr 1971;78:250–260
Danigelis JA, Markarian B. Pulmonary alveolar proteinosis including pulmonary electron microscopy. Am J Dis Child 1969;118:871–875
Davies G, Reid L. Growth of the alveoli and pulmonary arteries in childhood. Thorax 1970; 25:669–681
DeCesare JA, Babchyck BM, Colten HR, Treves S. Radionuclide assessment of the effects of chest physical therapy on ventilation in cystic fibrosis. Phys Ther 1982;62:820–827
Di Sant’Agnese PA, Davis PB. Research in cystic fibrosis [in three parts]. N Engl J Med 1976;295:481–485
Dunne EF. Cardiac Radiology. Philadelphia: Lea & Febiger, 1967
Dusser DJ, Collignon MA, Stanislas-Leugern G, et al. Respiratory clearance of 99mTc -DTPA and pulmonary involvement in sarcoidosis. Am Respir Dis 1986;134:493–497
Emery JL. Pulmonary embolism in children. Arch Dis Child 1962;37:591–595
Emery JL, Mithal A. The number of alveoli in the terminal respiratory unit of man during late intrauterine life and childhood. Arch Dis Child 1960;35:544–547
Epstein J, Taylor A, Alazraki N. Acute pulmonary embolus associated with transient ventilatory defect. JNuclMed 1975;16:1017–1020
Espinola D, Rupani H, Camargo EE, Wagner HN. Ventilation-perfusion imaging in pulmonary papillomatosis. J Nucl Med 1981;22:975–977
Esposito A, Gleckman RA. A diagnostic approach to the adult with fever of unknown origin. Arch Intern Med 1979;139:575–579
Fazio F, Jones T. Assessment of regional ventilation by continuous inhalation of radioactive krypton-81m. BMJ 1975;3:673–676
Felson B. Chest Roentgenology. Philadelphia: Saunders, 1973
Firor HV. Pulmonary embolization complicating total intravenous alimentation. J Pediatr Surg 1972;7:81–83
Fleming HA. Differential lung function in atrial septal defect. Circulation 1959;19:856–862
Fletcher BD, Outerbridge EW, Youssef S, Bolande RP. Pulmonary interstitial emphysema in a newborn infant treated by lobectomy. Pediatrics 1974; 54:808–811
Fraser RG, Pare J, et al. Diagnosis of Diseases of the Chest. Philadelphia: Saunders, 1977
Freiman DB, Sureymoto J, Wessler S. Frequency of pulmonary thromboembolism in man. N Engl J Med 1965;272:1270
Gandillo SB, Transwell AK, Mackie KW. Pulmonary vascular air embolism in hyaline membrane disease. J Can Assoc Radiol 1977;28: 294–296
Gittman JE, Buchanan TA, Fisher BJ, Bergeson PS, Palmer PE. Fatal pulmonary embolism after spinal fusion for scoliosis. JAMA 1983;249:779–781
Gooneratne N, Conway JJ. Radionuclide angiographic diagnosis of bronchopulmonary sequestration. J Nucl Med 1976;17:1035–1037
Grossman H, Berdon WE, Misrahi A, Baker DH. Neonatal focal hyperaeration of the lungs (Wilson-Mikity syndrome). Radiology 1965;85:409–417
Gupta RG, Beckerman C, Sicilian L, et al. Gallium-67 citrate scanning and serum angiotensin-converting enzyme levels in sarcoidosis. Radiology 1982;144:895–899
Gyepes MT, Bennett LR, Hassakis PC. Regional pulmonary blood flow in cystic fibrosis. AJR 1969;106:567–575
Hall RT, Rhodes PG. Pneumothorax and pneumomediastinum in infants with idiopathic respiratory distress syndrome receiving continuous positive airway pressure. Pediatrics 1975;55:493–496
Harker LA, Slichter SJ, Scott CR, Ross R. Homocystinemia: vascular injury and arterial thrombosis. N Engl J Med 1974;291:537–543
Harrod JR, L’Heureux P, Wagenstun OD, Hunt CE. Long-term foliowup of severe respiratory distress syndrome treated with IPPB. J Pediatr 1974;84: 277–285
Heyman S. Toxicity and safety factors associated with lung perfusion studies with radiolabeled particles [letter to the editor]. J Nucl Med 1979;20: 1098–1099
Higgins CB, Wexler L. Clinical and angiographic features of pulmonary arteriovenous fistulas in children. Radiology 1976;119:171–175
Hislop A, Reid L. New pathological findings in emphysema. Thorax 1970;25:682–690
Hughes JMB, Glazier JB, Maloney JE, West JB. Effect of interstitial pressure on pulmonary blood flow. Lancet 1967;1:192–193
Isawa T, Teshima T, Anazawa Y, Miki M, Motomiya M. Technegas for inhalation lung imaging. Nucl Med Commun 1991;12:47–55
James DG, Turiaf J, Hosoda Y, et al. Description of sarcoidosis: report of the subcommittee on classification and definition. Ann NY Acad Sci. 1976
James JM, Lloyd JJ, Leahy BC, et al. The incidence and severity of hypoxia associated with 99mTc Technegas ventilation scintigraphy and 99mTc MAA perfusion scintigraphy. Br J Radiol 1992; 65:403–408
Jefferies AL, Coates G, O’Brodovich H. Pulmonary epithelial permeability in hyaline membrane disease. N Engl J Med 1984;25:1075–1080
Jones DRB, MacIntyre IMC. Venous thromboembolism in infancy and childhood. Arch Dis Child 1975;50:153–155
Jones RH, Sabiston DC. Pulmonary embolism in childhood. Monogr Surg Sci 1966;3:35–51
Kelley MJ, Elliott LP. The radiologic evaluation of the patient with suspected pulmonary thromboembolic disease. Med Clin North Am 1975;59:3–36
Kessler RM, McNeil BJ. Impaired ventilation in a patient with angiographically demonstrated pulmonary emboli. Radiology 1975;114:111–112
Kim EE, DeLand FH. V/Q mismatch without pulmonary embolism in children with histoplasmosis. Clin Nucl Med 1978;3:328–330
Kimball AM, Hallum AV, Cates W. Deaths caused by pulmonary thromboembolism after legally induced abortion. Am J Obstet Gynecol 1978; 239:948–950
Kjellman B. Regional lung function studied with Xe-133 in children with pneumonia. Acta Paediatr Scand 1967;56:467–476
Klech H, Kohn H, Kummer F, Mostbeck A. Assessment of activity in sarcoidosis: sensitivity and spacificity of Ga-67 scintigraphy, serum ACE levels, chest roentgenography and blood lymphocyte subpopulations. Chest 1982;82:732–738
Kropp J, Burr W, Biersack HJ. Lung inhalation scintigraphy in newborns: a study with the new tracer Technegas. J Nucl Med 1989;30:1989
Kropp J, Overbeck B, Klumpp J, Hotze A, Biersack HJ. Inhalation scintigraphy with an ultrafine aerosol in infants with functional bronchial stenoses. Clin NuclMed 1993;18:223–226
Lassen NA. Assessment of tissue radiation dose in clinical use of radioactive inert gases with examples of absorbed dose from 3H, 85Kr, and 133Xe. Radioakt Isot Klin Fortschr 1965;6:37–47
Lee HK, Granada M. Swyer-James syndrome: diagnostic application of combined radionuclide ventilation and perfusion scanning. Clin Nucl Med 1977;2:100–102
Leonidas JC, Hall RT, Rhodes PG. Conservative management of unilateral pulmonary emphysema under tension. J Pediatr 1975;87:776–778
Leonidas JC, Moylan FM, Kahn PC, Ramenofsky ML. Ventilation-perfusion scans in neonatal regional pulmonary emphysema complicating ventilatory assistance. AJR 1978; 131:243–246
Li DK, Treves S, Heyman S, et al. Krypton-81m: a better radiopharmaceutical for the assessment of regional lung function in children. Radiology 1979;130:741–747
Li DL, Seltzer SE, McNeil BJ. V/Q mismatches unassociated with pulmonary embolism: case report and review of the literature. J Nucl Med 1978;19:1331–1333
Liebow AA, Steer A, Billingsley JG. Desquamative interstitial pneumonia. Am J Med 1965;39:369–404
Macklin MT, Macklin CC. Malignant interstitial emphysema of the lungs and mediastinum as an important occult complication in many respiratory disease and other conditions: an interpretation of the clinical literature in the light of laboratory experiment. Medicine (Baltimore) 1944;23:281–358
Makler PT, Malmud LS, Charkes ND. Diminished perfusion to an entire lung due to mucous plug. Clin Nucl Med 1977;2:160–162
McGoldrick PJ, Rudd TG, Figley MM, Wilheim JP. What becomes of pulmonary infarcts? AJR 1979;133:1039–1045
Medina JR, L’Heureux P, Lillehei JP, Loken MK. Regional ventilation in the differential diagnosis of pulmonary embolism. Circulation 1969;39:831–835
Meignan M, Rosso J, Leveau J, et al. Exercise increases the lung clearance of inhaled technetium-99m DTPA. J Nucl Med 1985;27:274–280
Merten DF, Kirks DR, Grossman H. Pulmonary sarcoidosis in childhood. AJR 1980;135:673–679
Miller T, Tanaka T. Nuclear scan of pulmonary hemorrhage in idiopathic pulmonary hemosiderosis. AJR 1979;132:120–121
Miorner G. 133Xe-radiospirometry: a clinical method for studying regional lung function. Scand J Respir Dis Suppl 1968;64:1–84
Mishkin F, Knote J. Radioisotope scanning of the lungs in patients with systemic-pulmonary anastomosis. AJR 1968;102:267–273
Mishkin F, Wagner HN. Regional abnormalities in pulmonary arterial blood flow during acute asthmatic attacks. Radiology 1967;88:142–144
Monaghan P, Provan I. Murray C, et al. An improved radionuclide technique for the detection of altered pulmonary permeability. J Nucl Med 1991 ;32: 1945–1949
Moore P, James O, Saltos N. Fat embolism syndrome: incidence, significance and early features. AustNZ JSurg 1981;51:546–551
Moses DC, Silver TM, Bookstein JT. The complementary roles of chest radiography, lung scanning, and selective pulmonary angiography in the diagnosis of pulmonary embolism. Circulation 1974; 49:179–188
Moyer JH, Glantz G, Brest AN. Pulmonary arteriovenous fistulas: physiologic and clinical considerations. Am J Med 1962;32:417–435
Nichols MM, Tyson KR. Saddle embolus occluding pulmonary arteries. Am J Dis Child 1978; 132:926
O’Brodovich H, Coates G. Pulmonary clearance of 99mTc -DTPA in infants who subsequently developed bronchopulmonary dysplasia. Am Rev Respir Dis 1988;137:210–212
O’Dell CW, Taylor A, Higgins CB, et al. Ventilation-perfusion lung images in the Swyer-James syndrome. Radiology 1976;121:423–426
Peltier P, DeFaucal P, Chetanneau A, Chatal JF. Comparison of technetium-99m aerosol and kryp-ton-81m in ventilation studies for the diagnosis of pulmonary embolism. Nucl Med Commun 1990;11:631–638
Piepsz A, Decostre P, Baran D. Scintigraphic study of pulmonary blood flow distribution in cystic fibrosis. J Nucl Med 1978;14:326–330
Pillay SV. Pulmonary embolism of cerebral tissue in a neonate: a case report. S Afr Med J 1980;20:498
Plenck HP, Swift SA, Chambers WL, Peltzer WE. Pulmonary alveolar proteinosis: a new disease? Radiology 1960;74:928–938
Rao M, Steiner P, Victoria MS, et al. Regional lung functions in children with asthma. J Asthma Res 1977;14:107–110
Rosen SH, Castleman B, Liebow AA. Pulmonary alveolar proteinosis. N Engl J Med 1958; 258:1123–1142
Rosso J, Guillon JM, Parrot A, et al. Technetium-99m aerosol and gallium-67 scanning in pulmonary complications of human immunodeficiency virus infection. J Nucl Med 1992;33:81–87
Sade RM, Williams RG, Castaneda AR, Treves S. Abnormalities of regional lung function associated with ventricular septal defect and pulmonary artery band. J Thorac Cardiovasc Surg 1976;71:572–580
Salzman EW, Harris WH, DeSanctis RW. Anticoagulation for prevention of thromboembolism following fracture of the hip. N Engl J Med 1966;275:122–130
Sasahara AA, Cannilia JE, Morse RL, Sidd JJ, Tremblay GM. Clinical and physiologic studies in pulmonary thromboembolism. Am J Cardiol 1967;20:10–20
Scalzetti EM, Grossman ZD, Gagne GM. Experimentally produced arterial occlusion in the dog: identification with pertechnegas inhalation. Radiology 1993;186:423–426
Schiff RG, Kabt L, Kamani N. Gallium scanning in lymphoid interstitial pneumonitis in children with AIDS. J Nucl Med 1987;28:1915–1919
Schor RA, Shames DM, Weber PM, and Dos Remedios LV. Regional ventilation studies with Kr-81m and Xe-133: a comparative analysis. J Nucl Med 1978;19:348–353
Shannon DC, Riseborough EJ, Valenca LM, Kazemi H. The distribution of abnormal lung function in kyphoscoliosis. J Bone Joint Surg [Am] 1970;52:131–144
Shwachman H, Kulczych LL, Khan KT. A report of 65 patients over 16 years of age. Pediatrics 1965;36:689–699
Stinnett RG, Hietala S, Fratkin MJ. Reversible unilateral pulmonary hypoperfusion secondary to mucous plugs. Clin Nucl Med 1977;2:157–159
Stocker JT, Drake RM, Madewell JE. Cystic and congenital lung disease in the newborn. Perspect Pediatr Pathol 1978;4:93–154
Sullivan PJ, Burke WM, Burch WM, Lomas FE. A clinical comparison of Technegas and xenon-133 in 50 patients with suspected pulmonary embolus. Chest 1988;94:300–304
Tan KL, Hwang WS. Neonatal brain tissue embolism in the lung. Aust NZ J Med 1976; 76:146–149
Tang TT, Chambers CH, Gallen WJ, McCready SR. Pulmonary fiber embolism and granuloma. JAMA 1978;239:948–950
Thurlbeck WM. Postnatal growth and development of the lung. In Murray JF (ed): Lung Disease. State of the Art (1974–1975). New York: American Lung Association, 1976
Treves S, Ahnberg DS, Laguarda R, Streider DJ. Radionuclide evaluation of regional lung function in children. J Nucl Med 1974;15:582–587
Treves S, Fogel R, Lang P. Radionuclide angiography in congenital heart disease. Am J Cardiol 1980;46:1247–1255
Treves S, Strieder DJ, Adelstein SJ. Scintillation camera radiospirometry. Prog Nucl Med 1973; 3:149–165
Treves ST, Harris CBC. Lung. In Treves ST (ed): Pediatric Nuclear Medicine. New York: Springer-Verlag, 1985;289–330
Utzon F, Bradrup F. Pulmonary arteriovenous fistulas in children: a review with special reference to the disperse telangiectatic type. Acta Paediatr Scand 1973;62:422–432
Vandevivere J, Spehl M, Dab J, Baran D, Piepsz A. Bronchiectasis in childhood: comparison of chest roentgenograms, bronchography and lung scintigraphy. Pediatr Radiol 1980;9:193–198
Wagner HNJ, Sabiston DC, Iio M, et al. Regional pulmonary blood flow in man by radioisotope scanning. JAMA 1964;187:601–603
Walker BK, Ballas SK, Burka ER. The diagnosis of pulmonary thromboembolism in sickle cell disease. Am JHematol 1979;7:219–232
Wartak J, Overton TR, Friedenberg LW, Sproule BJ. Computer-aided evaluation of regional pulmonary function. Comput Biomed Res 1972;5:429–439
Wesley JR, Keens TG, Miller SW, Platzker AC. Pulmonary embolism in the neonate: occurrence during the course of total parenteral nutrition. J Pediatr 1978;93:113–115
Wilkinson RH, Blanc WA, Hagstrom JWC. Pulmonary alveolar proteinosis in three infants. Pediatrics 1968;451:510–515
Wilson AF, Surprenant EL, Beall GN, et al. The significance of regional pulmonary function changes in bronchial asthma. Am J Med 1970;48:416–423
Wilson MG, Mikity VG. A new form of respiratory disease in premature infants. Am J Dis Child 1960;99:489–499
Winzelberg GG, Wholey MH, Sachs M. Scintigraphic localization of pulmonary bleeding using Tc-99m sulfur colloid: a preliminary report. Radiology 1982;143:757–762
Wohl M, Griscom NT, Streider DJ, et al. The lung following repair of congenital diaphragmatic hernia. J Pediatr 1977;90:405–414
Wood RE, Boat TF, Doershuk CF. Cystic fibrosis. Am Rev Respir Dis 1976;113:833–878
Zeiger LS, Moss EG. Ventilation and perfusion imaging in the Swyer-James syndrome. Clin Nucl Med 1977;2:103–105
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Treves, S.T., Packard, A.B. (1995). Lungs. In: Treves, S.T. (eds) Pediatric Nuclear Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4205-3_11
Download citation
DOI: https://doi.org/10.1007/978-1-4757-4205-3_11
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4757-4207-7
Online ISBN: 978-1-4757-4205-3
eBook Packages: Springer Book Archive