Trophoblastic Neoplasms

  • Kurt Benirschke
  • Peter Kaufmann


Choriocarcinoma is a malignant neoplasm composed exclusively of cytotrophoblast and syncytiotrophoblast. If villi are associated with such invasive tumors, the lesion is referred to as “invasive mole” or chorioadenoma destruens (see Chapter 22). In this discussion, only the truly neoplastic lesions of the gestational trophoblastic diseases (GTDs) are covered. The various classifications of GTDs have been alluded to in the previous chapter, and Soper et al. (1994), who evaluated 454 tumors according to three classifications, found the prognostic aspects to be fairly similar among these otherwise divergent classifications. Perhaps the clinical staging provided the best prognostication. An excellent and concise review of chorionic tumors has summarized recent progress in understanding and therapy of these lesions (Berkowitz & Goldstein, 1996).


Hydatidiform Mole Gestational Trophoblastic Disease Trophoblastic Tumor Gestational Trophoblastic Neoplasia Complete Hydatidiform Mole 
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© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Kurt Benirschke
    • 1
  • Peter Kaufmann
    • 2
  1. 1.University Medical CenterUniversity of California, San DiegoSan DiegoUSA
  2. 2.Institut für Anatomie der Medizinischen FakultätRheinisch-Westfälische Technische Hochschule AachenAachenGermany

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