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Choriocarcinoma

  • Chapter
Pathology of the Human Placenta

Abstract

Choriocarcinoma is a malignant neoplasm composed exclusively of cytotrophoblast and syncytiotrophoblast. If villi are associated with such invasive tumors, the lesion is referred to as invasive mole or chorioadenoma destruens (see Chapter 22). In this discussion, only the choriocarcinoma of gestational trophoblastic neoplasia is covered. The nature of this tumor was first correctly identified by Marchand (1895). Teacher’s detailed observations (1903) followed Marchand’s description. The early history of this tumor, the deciduoma as it was first known, has been admirably recounted by Ober and Fass (1961). Until the neoplastic elements of choriocarcinoma were ultimately shown to be derived from the embryonic cells, not the maternal cells, their derivation had been in dispute. Ewing (1910) was the first investigator to differentiate between the various types of trophoblastic neoplasm. He introduced or used the terms invasive mole, syncytial endometritis, and syncytioma. Some of these terms are still in usage even though some should now be replaced as greater knowledge of their biology has been accumulating.

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  1. University Medical Center, University of California, San Diego, 92103-8321, San Diego, California, USA

    Kurt Benirschke MD (Professor of Pathology and Reproductive Medicine)

  2. Institut für Anatomie der Medizinischen Fakultät, Rheinisch-Westfälische Technische Hochschule Aachen, 52057, Aachen, Germany

    Professor Dr. med. Peter Kaufmann

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Benirschke, K., Kaufmann, P. (1995). Choriocarcinoma. In: Pathology of the Human Placenta. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4196-4_23

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