• Kurt Benirschke
  • Peter Kaufmann


Choriocarcinoma is a malignant neoplasm composed exclusively of cytotrophoblast and syncytiotrophoblast. If villi are associated with such invasive tumors, the lesion is referred to as invasive mole or chorioadenoma destruens (see Chapter 22). In this discussion, only the choriocarcinoma of gestational trophoblastic neoplasia is covered. The nature of this tumor was first correctly identified by Marchand (1895). Teacher’s detailed observations (1903) followed Marchand’s description. The early history of this tumor, the deciduoma as it was first known, has been admirably recounted by Ober and Fass (1961). Until the neoplastic elements of choriocarcinoma were ultimately shown to be derived from the embryonic cells, not the maternal cells, their derivation had been in dispute. Ewing (1910) was the first investigator to differentiate between the various types of trophoblastic neoplasm. He introduced or used the terms invasive mole, syncytial endometritis, and syncytioma. Some of these terms are still in usage even though some should now be replaced as greater knowledge of their biology has been accumulating.


Ectopic Pregnancy Hydatidiform Mole Gestational Trophoblastic Disease Trophoblastic Tumor Gestational Trophoblastic Neoplasia 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Kurt Benirschke
    • 1
  • Peter Kaufmann
    • 2
  1. 1.University Medical CenterUniversity of California, San DiegoSan DiegoUSA
  2. 2.Institut für Anatomie der Medizinischen FakultätRheinisch-Westfälische Technische Hochschule AachenAachenGermany

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