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Fetal Storage Disorders

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Pathology of the Human Placenta

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Abstract

Many of the so-called errors in metabolism, the storage diseases, produce inclusions or vacuoles in the tissues of affected individuals. The placenta is often similarly involved, and chorionic villous biopsy (CVS) is now often employed to make the diagnosis prenatally, as for instance when diagnosing lipofuscinosis (Rapola et al., 1990). Electron microscopy and special enzyme studies may be necessary for the precise diagnosis of the defect involved. Thus appropriate fixation is needed and must be anticipated at the time of CVS, as many of the inclusions are highly water- and lipid-solvent-soluble. An excellent ultrastructural study of 11 cases has been reported by Jones et al. (1990) that details procedures and findings. It also depicts the findings in admirable detail and provides additional literature.

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Authors and Affiliations

  1. University Medical Center, University of California, San Diego, 92103-8321, San Diego, California, USA

    Kurt Benirschke MD (Professor of Pathology and Reproductive Medicine)

  2. Institut für Anatomie der Medizinischen Fakultät, Rheinisch-Westfälische Technische Hochschule Aachen, 52057, Aachen, Germany

    Professor Dr. med. Peter Kaufmann

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  1. Kurt Benirschke MD
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  2. Professor Dr. med. Peter Kaufmann
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© 1995 Springer Science+Business Media New York

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Benirschke, K., Kaufmann, P. (1995). Fetal Storage Disorders. In: Pathology of the Human Placenta. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4196-4_18

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  • DOI: https://doi.org/10.1007/978-1-4757-4196-4_18

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-4198-8

  • Online ISBN: 978-1-4757-4196-4

  • eBook Packages: Springer Book Archive

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