Benign Tumors

  • Kurt Benirschke
  • Peter Kaufmann

Abstract

With rare exceptions, vascular tumors are the only benign tumors of the placenta. Tumors designated chorioangiomas, chorangiomas, fibroangiomyxomas, fibromas, and the many other names that have been applied are essentially similar, relatively common neoplasms of the placenta. Two large reviews have been published that bring together most of the literature. Fox (1967), who also reviewed the often confused nomenclature, indicated that Clarke described the first such tumor in 1798. Since then, the review by Siddall (1924) encompassed 130 cases, that by Marchetti (1939) comprised 209 cases, and Fox traced another 127 cases. Fox accounted for 344 published cases and gave incidence figures of 1 in 9,000 to 1 in 50,000. 1 When careful study of placentas is undertaken, the real prevalence may be as high as 1 in 100 pregnancies, according to some authors, although in my experience this number is excessive.

Keywords

Benign Tumor Fetal Distress Cavernous Hemangioma Placenta Previa Villous Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adducci, J.E.: Chorioangioma of the placenta: causing fetal distress. Minn. Med. 58:820–821, 1975.PubMedGoogle Scholar
  2. Altshuler, G.: Chorangiosis: an important placental sign of neonatal morbidity and mortality. Arch. Pathol. Lab. Med. 108:71–74, 1984.PubMedGoogle Scholar
  3. Arodi, J., Auslender, R., Atad, J., and Abramovici, H.: Case report: giant chorioangioma of the placenta. Acta Obstet. Gynecol. Scand. 64:91–92, 1985.PubMedCrossRefGoogle Scholar
  4. Asadourian, L.A., and Taylor, H.B.: Clinical significance of placental hemangiomas. Obstet. Gynecol. 31:551–555, 1968.PubMedGoogle Scholar
  5. Barry, F.E., McCoy, C.P., and Callahan, W. P.: Hemangioma of the umbilical cord. Am. J. Obstet. Gynecol. 62:675–680, 1951.PubMedGoogle Scholar
  6. Battaglia, E.C., and Woolever, C.A.: Fetal and neonatal complications associated with recurrent chorioangi-omas. Pediatrics 41:62–66, 1968.PubMedGoogle Scholar
  7. Benson, R.E., and Joseph, M.C.: Cardiomegaly in a newborn due to placental chorioangioma. Br. Med. J. 1:102–105, 1961.PubMedCrossRefGoogle Scholar
  8. Burrows, S., Gaines, J.L., and Hughes, F.J.: Giant chorioangioma. Am. J. Obstet. Gynecol. 115:579–580,1973.PubMedGoogle Scholar
  9. Caldwell, C., Purohit, D.M., Levkoff, A.H., Garvin, A.J., Williamson, H.O., and Horger, E.O. III: Chorangiosis of the placenta with persistent transitional circulation. Am. J. Obstet. Gynecol. 127:435–436, 1977.PubMedGoogle Scholar
  10. Cary, W.H.: Report of a well-authenticated case of sarcoma of the placenta. Am. J. Obstet. 69:658–664, 1914.Google Scholar
  11. Cash, J.B., and Powell, D.E.: Placental chorioangioma: presentation of a case with electron-microscopic and immunochemical studies. Am. J. Surg. Pathol. 4:87–92, 1980.PubMedGoogle Scholar
  12. Castaldo, E., Guariglia, L., Lanzone, A., Marana, R., and Plotti, G.: Tumori non trofoblastici della placenta. I: Tumori primitivi. Recenti Prog. Med. 70: 445–456, 1981.PubMedGoogle Scholar
  13. Chen, K.T.K., Ma, C.K., and Kassel, S.H.: Hepatocellular adenoma of the placenta. Am. J. Surg. Pathol. 10:436–440, 1986.PubMedCrossRefGoogle Scholar
  14. Cohen, M.I., and Sinclair, J.C.: Neonatal death from congestive heart failure associated with large cutaneous cavernous hemangioma. Pediatrics 32:924–925, 1963.PubMedGoogle Scholar
  15. Cooper, A.G., and Bolande, R.P.: Multiple hemangiomas in an infant with cardiac hypertrophy: postmortem angiographic demonstration of the arteriovenous fistulae. Pediatrics 35:27–35, 1965PubMedGoogle Scholar
  16. Corcoran, C.J., and Murphy, E.C.: Rare bovine placental tumour-a case report. Vet. Rec. 77:1234–1235, 1965.PubMedCrossRefGoogle Scholar
  17. Cox, J.N., and Chavrier, P.: Heterotopic adrenocortical tissue within a placenta. Placenta 1:131–133, 1980.PubMedCrossRefGoogle Scholar
  18. Daniel, S.J., and Cassady, G.: Non-immunologie hydrops fetalis associated with a large hemangioendothelioma. Pediatrics 42:829–833, 1968.Google Scholar
  19. Dao, A.H., Rogers, C.W., and Wong, S.W.: Chorioan-gioma of the placenta: report of 2 cases with ultrasound study in 1. Obstet. Gynecol. 57:46S–49S, 1981.Google Scholar
  20. Dunn, R.I.S.: Haemangioma of the placenta (chorioangioma). J. Obstet. Gynaecol. Br. Emp. 66:51–57, 1959.PubMedCrossRefGoogle Scholar
  21. Earn, A.A., and Penner, D.W.: Five cases of chorio-angioma. J. Obstet. Gynaecol. Br. Emp. 57:442–444, 1950.PubMedCrossRefGoogle Scholar
  22. Eldar-Geva, T., Hochner-Celnikier, D., Ariel, I., Ron, M., and Yagel, S.: Fetal high output cardiac failure and acute hydramnios caused by large placental chor-ioangioma: case report. Br. J. Obstet. Gynaecol. 95: 1200–1203, 1988.PubMedCrossRefGoogle Scholar
  23. Fox, H.: Vascular tumors of the placenta. Obstet. Gynecol. Surv. 22:697–711, 1967.PubMedCrossRefGoogle Scholar
  24. Fox, H.: Pathology of the Placenta. Saunders, London, 1978.Google Scholar
  25. Froehlich, L.A., and Housler, M.: Neonatal thrombocytopenia and chorangioma. J. Pediatr. 78:516–519, 1971.PubMedCrossRefGoogle Scholar
  26. Froehlich, L.A., Fujikura, T., and Fisher, P.: Chorio-angiomas and their clinical implications. Obstet. Gynecol. 37:51–59, 1971.PubMedGoogle Scholar
  27. Greene, E.E., and Lams, J.D.: Chorioangioma: a case presentation. Am. J. Obstet. Gynecol. 148:1146–1148, 1984.PubMedGoogle Scholar
  28. Heggtveit, H.A., de Carvalho R., and Nuyens, A.J.: Chorioangioma and toxemia of pregnancy. Am. J. Obstet. Gynecol. 91:291–292, 1965.PubMedGoogle Scholar
  29. Hörmann, G.: Zur Systematik einer Pathologie der menschlichen Plazenta. Arch. Gynäkol. 191:297–344, 1958.PubMedCrossRefGoogle Scholar
  30. Imakita, M., Yutani, C., Ishibashi-Ueda, H., Murakami, M., and Chiba, Y.: A case of hydrops fetalis due to placental chorioangioma. Acta Pathol. Jpn. 38: 941–945, 1988.PubMedGoogle Scholar
  31. Jauniaux, E., Zucker, M., Meuris, S., Verherst, A., Wilkin, P., and Hustin, J.: Chorangiocarcinoma: an unusual tumour of the placenta: the missing link? Placenta 9:607–613, 1988.PubMedCrossRefGoogle Scholar
  32. Keenan, W.J., and Altshuler, G.: Massive pulmonary hemorrhage in a neonate. J. Pediatr. 86:466–471, 1975.PubMedCrossRefGoogle Scholar
  33. Kim, C.K., Benirschke, K., and Connolly, K.S.: Chorangioma of the placenta: chromosomal and electron microscopic studies. Obstet. Gynecol. 37:372 – 376, 1971.Google Scholar
  34. King, C.R., and Lovrien, E.W.: Chorioangioma of the placenta and intrauterine growth failure. J. Pediatr. 93:1027–1028, 1978.PubMedCrossRefGoogle Scholar
  35. Kirkbride, C.A., Bicknell, E.J., and Robl, M.G.: Hemangioma of a bovine fetus with a chorioangioma of the placenta. Vet. Pathol. 10:238–240, 1073.CrossRefGoogle Scholar
  36. Klaften, E.: Chorionhaemangioma placentae. Z. Geburtshilfe Gynäkol. 95:426–437, 1929.Google Scholar
  37. Knoth, M., Rygaard, J., and Hesseldahl, H.: Chorioangioma with hydramnios and intra-uterine fetal death. Acta Obstet. Gynecol. Scand. 55:279–281, 1976.PubMedCrossRefGoogle Scholar
  38. Kühnel, P.: Placental chorangioma. Acta Obstet. Gynecol. Scand. 13:143–194, 1933.CrossRefGoogle Scholar
  39. Leblanc, A., and Carrier, C.: Chorio-angiome placentaire, angiomes cutanés et cholestase néonatale. Arch. Fr. Pédiatr. 36:484–486, 1979.PubMedGoogle Scholar
  40. Limaye, N.S., and Tchabo, J.-G.: Asymptomatic thrombocytopenia associated with chorioangioma of placenta. Am. J. Obstet. Gynecol. 161:76–77, 1989.PubMedCrossRefGoogle Scholar
  41. Linder, D., and Gartier, S.M.: Glucose-6-phosphate dehydrogenase mosaicism: utilization as a cell marker in the study of leiomyomas. Science 150:67–69, 1965.PubMedCrossRefGoogle Scholar
  42. Lopez, H.B.B., and Kristoffersen, S.E.: Chorioangioma of the placenta. Gynecol. Obstet. Invest. 28:108–110, 1989.PubMedCrossRefGoogle Scholar
  43. Mahmood, K.: Small chorioangiomas and small-for-gestational age baby. Am. J. Obstet. Gynecol. 127: 440–442, 1977.PubMedGoogle Scholar
  44. Majlessi, H.P., Wagner, K.M., and Brooks, J.J.: Atypical cellular chorangioma of the placenta. Int. J. Gynecol. Pathol. 1:403–408, 1983.PubMedCrossRefGoogle Scholar
  45. Mandelbaum, B., Ross, M., and Riddle, C.B.: Hemangioma of the placenta associated with fetal anemia and edema: report of a case. Obstet. Gynecol. 34: 335–338, 1969.PubMedGoogle Scholar
  46. Marchetti, A.A.: A consideration of certain types of benign tumors of the placenta. Surg. Gynecol. Obstet. 68:733–743, 1939.Google Scholar
  47. Meinroy, R.A., and Kelsey, H.A.: Chorio-angioma (haemangioma of placenta) associated with acute hydramnios. J. Pathol. Bacteriol. 68:519–523, 1954.CrossRefGoogle Scholar
  48. Meyenburg, H.v.: Über Hemangiomatosis diffusa placentae. Beitr. Pathol. Anat. Allg. Pathol. 70:510–512, 1922.Google Scholar
  49. Müller, G., and Rieckert, H.: Beitrag zur Frage der Placentarinsuffizienz an Hand eines diffusen Choran-gioms. Arch. Gynäkol. 204:78–88, 1967.PubMedCrossRefGoogle Scholar
  50. Murray, D.E., Meyerowitz, B.R., and Hutter, J.J.: Congenital arteriovenous fistula causing congestive heart failure in the newborn. J.A.M.A. 209:770–771, 1969.PubMedCrossRefGoogle Scholar
  51. Philippe, E., Müller, G., Dehalleux, J.-M., Lefakis, P., and Gandar, R.: Le chorio-angiome et ses complica-tions foeto-maternelles. Rev. Fr. Gynecol. 64:335–341, 1969.Google Scholar
  52. Reiner, L., and Fries, E.: Chorangioma associated with arteriovenous aneurysm. Am. J. Obstet. Gynecol. 93: 58–64, 1965.PubMedGoogle Scholar
  53. Santamaria, M., Benirschke, K., Carpenter, P.M., Baldwin, V.J., and Pritchard, J.A.: Transplacental hemorrhage associated with placental neoplasms. Pediatr. Pathol. 7:601–615, 1987.PubMedCrossRefGoogle Scholar
  54. Schulz-Hetzel, I.: Über das Chorioangiom. Arch. Gynäkol. 225:131–146, 1978.PubMedCrossRefGoogle Scholar
  55. Sen, D.K.: Placental hypertrophy associated with chorio-angioma. Am. J. Obstet. Gynecol. 107:652–654, 1970.PubMedGoogle Scholar
  56. Siddall, R.S.: Chorioangiofibroma (chorioangioma). Am. J. Obstet. Gynecol. 8:430–456; 554–568, 1924.Google Scholar
  57. Sieracki, J.C., Panke, T.W., Horvat, B.L., Perrin, E.V., and Nanda, B.: Chorioangiomas. Obstet. Gynecol. 46:155–159, 1975.PubMedGoogle Scholar
  58. Stiller, A.G., and Skafish, P.R.: Placental chorangioma: a rare cause of fetomaternal transfusion with maternal hemolysis and fetal distress. Obstet. Gynecol. 67: 296–298, 1986.PubMedCrossRefGoogle Scholar
  59. Sulman, F.G., and Sulman, E.: Increased gonadotrophin production in a case of detachment of placenta due to placental haemangioma. J. Obstet. Gynaecol. Br. Emp. 56:1033–1034, 1949.PubMedCrossRefGoogle Scholar
  60. Sweet, L., Reid, W.D., and Robertson, N.R.C.: Hydrops fetalis in association with chorioangioma of the placenta. J. Pediatr. 82:91–94, 1973.PubMedCrossRefGoogle Scholar
  61. Wallenburg, H.C.S.: Chorioangioma of the placenta: thirteen new cases and a review of the literature from 1939–1970 with special reference to the clinical complications. Obstet. Gynecol. Surv. 26:411–425, 1971.PubMedCrossRefGoogle Scholar
  62. Williams, J.T.: Angioma of the placenta: with pathological report and microphotography by Dr. Frank B. Mallory. Surg. Gynecol. Obstet. 32:523–526, 1921.Google Scholar
  63. Wurster, D.H., Hoefnagel, D., Benirschke, K., and Allen, F.H.: Placental chorangiomata and mental deficiency in a child with 2/15 translocation; 46XX; t(2q-; 15q+). Cytogenetics 8:389–399, 1969.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Kurt Benirschke
    • 1
    • 2
  • Peter Kaufmann
    • 3
  1. 1.Pathology and Reproductive MedicineUniversity of CaliforniaSan DiegoUSA
  2. 2.University Medical CenterSan DiegoUSA
  3. 3.Institut für Anatomie der Medizinischen Fakultät, Rheinisch-Westfälische TechnischeHochschule AachenAachenGermany

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