• Kurt Benirschke
  • Peter Kaufmann


Choriocarcinoma is a malignant neoplasm composed exclusively of cytotrophoblast and syncytio-trophoblast. In this discussion, only the choriocarcinoma of “gestational trophoblastic neoplasia” is covered. The nature of this tumor was first correctly identified by Marchand (1895). Teacher’s detailed observations (1903) followed Marchanda description. The early history of this tumor, the “deciduoma” as it was first known, has been admirably recounted by Ober and Fass (1961). Until the neoplastic elements of choriocarcinoma were ultimately shown to be derived from the embryo, their derivation had been in dispute. Ewing (1910) was the first investigator to differentiate between the various types of trophoblastic neoplasm. He introduced the terms invasive mole, syncytial endometritis, and syncytioma.


Ectopic Pregnancy Normal Pregnancy Hydatidiform Mole Gestational Trophoblastic Disease Trophoblastic Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Kurt Benirschke
    • 1
    • 2
  • Peter Kaufmann
    • 3
  1. 1.Pathology and Reproductive MedicineUniversity of CaliforniaSan DiegoUSA
  2. 2.University Medical CenterSan DiegoUSA
  3. 3.Institut für Anatomie der Medizinischen Fakultät, Rheinisch-Westfälische TechnischeHochschule AachenAachenGermany

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