Kinetics of Topically Applied Ophthalmic Drugs

  • D. M. Maurice
Part of the FIDIA Research Series book series (FIDIA, volume 11)


The more important aspects of the behavior of drugs in the tear film and after penetration into the eye are described. The kinetics of lipophilic molecules is differentiated from that of hydrophilic. The importance of the lens as a reservoir is suggested.


Anterior Chamber Prednisolone Acetate Pulse Delivery Ophthalmic Drug Adenine Arabinoside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Adler CA, Maurice DM, Paterson ME (1971) The effect of viscosity of the vehicle on the penetration of fluorescein into the human eye. Exp Eye Res 11: 34–42.PubMedCrossRefGoogle Scholar
  2. Anderson JA, Chen CC, Vita JB, Shackleton Pi (1982) Disposition of topical flurbiprofen in normal and aphakic rabbit eyes. Arch Ophthalmol 100: 642–645.PubMedCrossRefGoogle Scholar
  3. Beasley H, Boltralik JJ, Baldwin HA (1975) Chloramphenicol in aqueous humor after topical application. Arch Ophthalmol 93: 184–185.PubMedCrossRefGoogle Scholar
  4. Ellerhorst B, Golden B, Nabil J (1975) Ocular penetration of topically applied gentamicin. Arch Ophthalmol 93: 371–379.CrossRefGoogle Scholar
  5. Guss R, Johnson F, Maurice D (1984) Rhodamine B as a test molecule in intraocular dynamics. Invest Ophthalmol Vis Sci 25: 758–762.PubMedGoogle Scholar
  6. Hamard H, Schmitt C, Plazonnet B, LeDouarec JS (1975) etude de la penetration oculaire de la dexaméthasone. In: DeMailly P, Hamard H, Luton JP (eds): Oeil et cortisone. Masson and Cie, Paris; pp. 3–81.Google Scholar
  7. Kaiser RJ, Maurice DM (1964) The diffusion of fluorescein in the lens. Exp Eye Res 3: 156–165.PubMedCrossRefGoogle Scholar
  8. Krohn DL (1978) Flux of topical pilocarpine to the human aqueous. Trans Am Soc Ophthalmol 76: 502–527.Google Scholar
  9. Leibowitz HM, Berrospi AR, Kupferman A, Restropo GV, Galvis V, Alvarez JA (1977) Penetration of topically administered prednisolone acetate into the human aqueous humor. Am J Ophthalmol 83: 402–406.PubMedGoogle Scholar
  10. Makoid MC, Robinson JR (1979) Pharmacokinetics of topically applied pilocarpine in the albino rabbit eye. J Pharm Sci 68: 435–443.PubMedCrossRefGoogle Scholar
  11. Maurice DM, Mishima S (1984) Ocular pharmacokinetics. In: Sears ML Handbook of experimental pharmacokinetics. Springer Verlag, Berlin; pp. 19–116.Google Scholar
  12. Maurice DM (1973) The dynamics and drainage of tears. Intl Ophthalmol Clin 13: 103–116.CrossRefGoogle Scholar
  13. Pavan-Langston D, Nelson DJ (1979) Intraocular penetration of trifluridine. Am J Ophthalmol 87: 814–818.PubMedGoogle Scholar
  14. Phillips CI, Bartholomew RS, Ghulamqadir K, Schmitt CJ, Vogen R (1981) Penetration of timolol eye drops into human aqueous humour. Br J Ophthalmol 65: 593–595.PubMedCrossRefGoogle Scholar
  15. Poirier RH, Kinkel AW, Ellison AC, Lewis R (1975) Intraocular penetration of topical 3% adenine arabinoside. In: Pavan-Langston D, Buchanan RA, Alford, CA (eds): Adenine arabinoside: an antiviral agent. Raven Press, New York: pp. 307–312.Google Scholar
  16. Sanders DR, Goldstick B, Kraff C, Hutchins R, Bernstein MS, Evasn MA (1983) Aqueous penetration of oral and topical indomethacin in humans. Arch Ophthalmol 101: 1614–1616.PubMedCrossRefGoogle Scholar
  17. Sieg JW, Robinson JR (1976) Mechanistic studies on transcorneal permeation of pilocarpine. J Pharm Sci 65: 1816–1822.PubMedCrossRefGoogle Scholar
  18. Sugar J, Burde RM, Sugar A, Waltman SR, Kripalani KJ, Weliky I, Becker B (1972) Tetrahydrotriamcinolone and triamcinolone I. Ocular penetration. Invest Ophthalmol 11: 890–893.PubMedGoogle Scholar
  19. Urtti A, Salminen, L (1986) Concentration-dependent precorneal loss of pilocarpine in rabbit eyes. Acta Ophthalmol (in press).Google Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • D. M. Maurice
    • 1
  1. 1.Division of OphthalmologyStanford UniversityStanfordUSA

Personalised recommendations