Factors Influencing the Retention of Ophthalmic Solutions on the Eye Surface

  • M. M. Van Ooteghem
Part of the FIDIA Research Series book series (FIDIA, volume 11)


The instillation of an ophthalmic solution generally initiates reflex tears and reflex blinking, which attempt to remove quickly the instilled solution from the eye surface. Reflex tears and reflex blinking are often elicited by different properties of the instilled solutions, such as the instilled volume, the osmolality, the pH and viscosity of the solution, and also by the physical and chemical properties of the drugs and the adjuvants present.


Ophthalmic Solution Foreign Matter Lens Wear Keratoconjunctivitis Sicca Reflex Blink 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • M. M. Van Ooteghem
    • 1
  1. 1.Department of Pharmaceutical SciencesUniversity of AntwerpWilrijkBelgium

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