Surfactant Pharmacokinetics in the Eye

  • K. Green
  • L. Cheeks
  • J. M. Chapman
Part of the FIDIA Research Series book series (FIDIA, volume 11)


The ocular pharmacokinetics of benzalkonium chloride (BAK) and sodium lauryl sulfate (SLS) have been determined in neonatal, young, and adult rabbits. BAK is confined to the cornea and conjunctiva, while SLS distributes widely. After single- or multiple-drop administration, the order of accumulation is neonatal > young > adult eye. Multiple-drop administration leads to accumulation to a tissue dependent steady state. BAK and SLS alter membrane permeability and can alter protein profiles of neonatal cells in culture. Such changes may alter tissue growth and differentiation.


Aqueous Humor Sodium Lauryl Sulfate Corneal Epithelium Benzalkonium Chloride Adult Rabbit 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • K. Green
    • 1
    • 2
  • L. Cheeks
    • 1
  • J. M. Chapman
    • 1
  1. 1.Department of OphthalmologyMedical College of GeorgiaAugustaUSA
  2. 2.Department of Physiology and EndocrinologyMedical College of GeorgiaAugustaUSA

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