Abstract
The ocular pharmacokinetics of benzalkonium chloride (BAK) and sodium lauryl sulfate (SLS) have been determined in neonatal, young, and adult rabbits. BAK is confined to the cornea and conjunctiva, while SLS distributes widely. After single- or multiple-drop administration, the order of accumulation is neonatal > young > adult eye. Multiple-drop administration leads to accumulation to a tissue dependent steady state. BAK and SLS alter membrane permeability and can alter protein profiles of neonatal cells in culture. Such changes may alter tissue growth and differentiation.
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References
Araie M, Tabase M, Sakai Y, Ishii Y, Yokoyama Y, and Kitagawa M (1982) Beta adrenergic blockers: Ocular penetration and binding to uveal pigment. Jap J Ophthalmol. 26: 248–263.
Clayton RM, Green K, Wilson M, Zehir A, Jack J and Searle L (1985) The penetration of detergents into adult and infant eyes: Possible hazards of additives to ophthalmic preparations. Fd Chem Tox 23: 239–246.
Godbey REW, Green K and Hull DS (1979) Influence of cetylpyridinium chloride on corneal permeability to penicillin. J Pharm Sci 68: 1176–1180.
Green K (1976) Electrophysiological and anatomical effects of cetylpyridinium chloride on the rabbit cornea. Acta Ophthalmol (Kbh) 54: 145–159.
Green K and Chapman JM (1986) Benzalkonium chloride kinetics in young and adult albino and pigmented rabbit eyes. J Toxicol Cutan Ocular Toxicol 5: 132–142.
Green K and Downs S (1974) Prednisolone phosphate penetration into and through the cornea. Invest Ophthalmol 13: 316–319.
Green K and Downs S (1975) Ocular penetration of pilocarpine in rabbits. Arch Ophthalmol 93: 1165–1168.
Green K, Hull DS, Vaughn E, Malizia A and Bowman K (1977) Rabbit endothelial response to ophthalmic preservatives. Arch Ophthalmol 95: 2218–2221.
Green K and Tonjum AM (1975) The effect of benzalkonium chloride on the electropotential of the rabbit cornea. Acta Ophthalmol (Kbh) 53: 348–357.
Marsh RJ and Maurice DM (1971) Influence of non-ionic detergents and other surfactants on human corneal permeability. Exp Eye Res 11: 43–48.
Miller SC and Patton TF (1981) Age-related differences in ophthalmic drug disposition: I. Effect of size on the intraocular tissue distribution in albino rabbits. Biopharm Drug Dispos 2: 215–233.
O’Brien CS and Swan KC (1942) Carbaminoylcholine chloride in the treatment of glaucoma simplex. Arch Ophthalmol 27: 253–263.
Patton TF (1977) Pediatric dosing considerations in ophthalmology: dosage adjustments based on aqueous humor volume ratio. J Ped Ophthalmol 14: 254–256.
Tonjum AM (1975) Effects of benzalkonium chloride upon the corneal epithelium studied with scanning electron microscopy. Acta Ophthalmol (Kbh) 53: 358–366.
Tonjum AM (1977) Permeability of the rabbit corneal epithelium to horseradish peroxidase after the influence of benzalkonium chloride. Acta Ophthalmol (Kbh) 54: 335–347.
Wei C, Anderson JA and Leopold I (1978) Ocular absorption and metabolism of topically applied epinephrine and a dipivalyl ester of epinephrine. Invest Ophthalmol Vis Sci 17: 315–321.
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© 1987 Springer Science+Business Media New York
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Green, K., Cheeks, L., Chapman, J.M. (1987). Surfactant Pharmacokinetics in the Eye. In: Saettone, M.F., Bucci, M., Speiser, P. (eds) Ophthalmic Drug Delivery. FIDIA Research Series, vol 11. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4175-9_17
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DOI: https://doi.org/10.1007/978-1-4757-4175-9_17
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