Pilocarpine Inserts: Experimental and Clinical Experiences
During the last 15 years about ten pilocarpine ocular inserts — most of soluble hydrophilic polymers — have been presented. In vitro studies demonstrated prolongation of pilocarpine release from these systems as compared to pilocarpine solutions. In in vivo studies in rabbits the hydrophilic inserts gelled in minutes and dissolved in hours. The magnitude of maximum pupil size constriction was enhanced, with duration of miosis significantly increased over that of liquid dosage systems. Few pilocarpine inserts have been tested in human eyes and in clinical use is only one type (Maichuk, 1976).
KeywordsAlbino Rabbit Ocular Drug Delivery Pigment Rabbit Ocular Insert Pilocarpine Hydrochloride
Unable to display preview. Download preview PDF.
- Katz IM, Blackman WM (1977) A soluble sustained-release ophthalmic delivery unit. Amer J Ophthalmol 83: 728–734.Google Scholar
- Lerman S (1970) Simulated sustained release pilocarpine therapy. Ann Ophthalmol 2: 435–439.Google Scholar
- Maichuk YF (1976) Polymeric drug delivery systems in ophthalmology. In: Leopold IH, Burns RP (eds): Ocular therapy. John Wiley and Sons, New York; pp. 1–16.Google Scholar
- Maichuk YF, Erichev VP (1981) Soluble ophthalmic drug inserts with pilocarpine: experimental and clinical study. Glaucoma 3: 239–242.Google Scholar
- Maichuk YF (1985) Medicated eye films. Medexport, Moscow;pp.l-66.Google Scholar
- Maurice DM, Mishima S (1984) Ocular pharmacokinetics. In: Sears ML (ed): Handbook of experimental pharmacology, Vol. 69. Springer-Verlag, Berlin-Heidelberg; pp. 19–116.Google Scholar
- Urtti A, Juslin M, Miinalainen 0 (1985b) Pilocarpine release from hydroxypropylcellulose-polyvinylpirrolidone matrices. Int J Pharm 25: 165–178.Google Scholar
- Urtti A (1985d) Deliverial and pharmacokinetic aspects of ocular pilocarpine administration. University of Kuopio, Kuopio; pp. 1–94.Google Scholar
- Urtti A, Salminen L, Miinalainen 0 (1985e) Systemic absorption of ocular pilocarpine is modified by polymer matrices. Int J Pharm 23: 147–161.Google Scholar
- Yoshida S, Mishima S (1975) A pharmacokinetic analysis of the pupil response to topical pilocarpine and tropicamide. Jpn J Ophthalmol 19: 121–138.Google Scholar