The Importance of Optimizing Corneal Penetration

  • R. D. Schoenwald
Part of the FIDIA Research Series book series (FIDIA, volume 11)


The extent of absorption occurring from the instillation of drugs topically to the eye is severely limited by physiological constraints. Consequently, it is important to consider optimizing corneal penetration in the development of a new ophthalmic drug. For some drugs an increase in the penetration rate results in a dramatic increase in effect. However, for certain drugs other pharmacokinetic processes, i.e. distribution, may be more critical to increased effectiveness. Examples are presented.


Aqueous Humor Rabbit Cornea Corneal Layer Diffusional Path Length Ophthalmic Drug 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • R. D. Schoenwald
    • 1
  1. 1.College of PharmacyUniversity of IowaIowa CityUSA

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