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Aging and Neurological Disease

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Abstract

The emerging discipline of gerontology is receiving increasing attention. Aging can be thought of as a natural progressive deterioration that may be genetically programmed. The question is, when does “aging” begin? There are genetic syndromes in humans with many features of accelerated aging, such as Downs syndrome and progeria (1). In this context, it is thought that motoneuron aging is programmed genetically, but that secondary factors may influence the time course (e.g., exhaustion of motoneurons following increased metabolic demands).

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References

  1. Giaquinto S: Aging and the Nervous System. New York, John Wiley & Sons, 1988.

    Google Scholar 

  2. McComas AJ, Lipton ARM, Sica REP: Motoneuron disease and aging. Lancet 1973;2:1477–1480.

    Article  PubMed  CAS  Google Scholar 

  3. Groher ME, Bukatman R: The prevalence of swallowing disorders in two teaching hospitals. Dysphagia 1986;1:3–6.

    Article  Google Scholar 

  4. Malmgren LT: Aging related changes in peripheral nerves in the head and neck, in Goldstein JC, Kashima HK, Koopmann CF (eds): Geriatric Otorhinolaryngology. Toronto, Brian C. Decker Inc, 1989.

    Google Scholar 

  5. Pontoppidan H, Beecher HK: Progressive loss of protective reflexes in the airway with the advance of age. JAMA 1960;174:2209–2213.

    Article  PubMed  CAS  Google Scholar 

  6. Kashima HK: Presbyphagia, introduction, in Goldstein JC, Kashima HK, Koopmann CF (eds): Geriatric Otorhinolaryngology. Toronto, Brian C. Decker Inc, 1989.

    Google Scholar 

  7. Rosenheimer JL, Smith DO: Differential changes in the end-plate architecture of functionally diverse muscles during aging. J Neurophysiol 1985;53:1567–1581.

    PubMed  CAS  Google Scholar 

  8. Baum BJ, Bodner L: Aging and oral motor function: Evidence for altered performance among older persons. J Dental Res l983;62(1):2–6.

    Article  Google Scholar 

  9. Osterberg T, Carlsson G: Symptoms and signs of mandibular dysfunction in 70-year old men and women in Gothenburg, Sweden. Community Dent Oral Epidemiol 1979;7:315–321.

    Article  PubMed  CAS  Google Scholar 

  10. Rolls BJ: Regulation of food and fluid intake in the elderly: Nutrition and the chemical senses, in Aging: Recent Advances and Current Research Needs, publ no. 561. New York, The New York Academy of Sciences, 1989, pp 217–225.

    Google Scholar 

  11. Kaplan H: The oral cavity in geriatrics. Geriatrics 1971;26:96–102.

    PubMed  CAS  Google Scholar 

  12. Tracy JF, Logemann JA, Kahrilas PJ, Kobara M, Krugler C: Preliminary observations on the effects of age on oropharyngeal deglutition. Dysphagia 1989;4:90–94.

    Article  PubMed  CAS  Google Scholar 

  13. Feldman RS, Kapur KK, Alman JE, et al: Aging and mastication changes in performance and in the swallowing threshold with natural dentition. J Am Geriatr Soc 1980;28(3):96–102.

    Google Scholar 

  14. Shaker R, Dodds WJ, Hogan WJ, Stemper AK: Effect of aging on swallow induced lingual palatal closure pressure. Gastroenterology 1989;96:A464.

    Google Scholar 

  15. Buchholz DW, Donner MW, Bosma JF: Adaption, compensation and decompensation of the pharyngeal swallow. Gastrointest Radiol 1985;10:235–239.

    Article  PubMed  CAS  Google Scholar 

  16. Ferreri G: Senescence of the larynx. Ital Gen Rev Otorhinolaryngol 1959;1:640–709.

    Google Scholar 

  17. Kahane JC: Postnatal development and aging of the human larynx. Semin Speech Lang 1983;4:189–203.

    Google Scholar 

  18. Borgstrom PS, Ekberg O: Pharyngeal dysfunction in the elderly. J Med Imaging 1988;2:74–81.

    Google Scholar 

  19. Sonies BC, Stone, M, Shawker T: Speech and swallowing in the elderly. Gerodontology 1984;3:115–123.

    Article  PubMed  CAS  Google Scholar 

  20. Borgstrom PS, Ekberg O: Speed of peristalsis in pharyngeal constrictor musculature: Correlations to age. Dysphagia 1988;2:140–144.

    Article  PubMed  CAS  Google Scholar 

  21. Hellemans J, Vantrappen G: Presbyesophagus, in Diseases of the Esophagus. Berlin, SpringerVerlag, 1974, pp 372–378.

    Chapter  Google Scholar 

  22. Zboralske FF, Amberg JR, Soergel KH: Presbyesophagus: Cine-radiographic manifestations. Radiology 1964;82:463–467.

    PubMed  CAS  Google Scholar 

  23. Mandelstam P, Lieber A: Cineradiographic evaluation of the esophagus in normal adults. Gastroenterology 1970;58:32–39.

    PubMed  CAS  Google Scholar 

  24. Geokas MC, Conteas CN, Majundar APN: The aging gastrointestinal tract, liver, and pancreas. Clin Geriatr Med 1985;1:177–205.

    PubMed  CAS  Google Scholar 

  25. Eckardt VF, LeCompte PM: Histology of esophageal smooth muscle and Auerbach’s plexus in elderly persons. Gastroenterology 1977;72:1055.

    Google Scholar 

  26. Hollis JB, Castell DO: Esophageal function in elderly men: A new look at presbyesophagus. Ann Intern Med 1974;80:371.

    PubMed  CAS  Google Scholar 

  27. Khan TA, Shragge RW, Crispin JS, Lind JF: Esophageal motility in the elderly. Am J Dig Dis 1977;22:1049–1054.

    Article  PubMed  CAS  Google Scholar 

  28. Soergel KH, Zboralske FF, Auberg JR: Presbyesophagus: Esophageal motility in nonagenarians. J Clin Invest 1964;43:1472–1479.

    Article  PubMed  CAS  Google Scholar 

  29. Buchholz D: Neurologic causes of dysphagia. Dysphagia 1987;1:152–156.

    Article  Google Scholar 

  30. Kirshner S: Causes of neurogenic dysphagia. Dysphagia 1989;3:184–188.

    Article  PubMed  CAS  Google Scholar 

  31. Silbiger ML, Pikheney R, Donner MW: Neuromuscular disorders affecting the pharynx: Cineradiographic analysis. Invest Radiol 1967;2:442–448.

    Article  PubMed  CAS  Google Scholar 

  32. Veis SL, Logemann JA: Swallowing disorders in persons with cerebrovascular accident. Arch Phys Med Rehabil 1985;66:372–375.

    PubMed  CAS  Google Scholar 

  33. Gordon C, Hewer RL, Wade DT: Dysphagia in acute stroke. Br Med J 1987;295:411–414.

    Article  CAS  Google Scholar 

  34. Robbins JA, Levine RL: Swallowing after unilateral stroke of the cerebral cortex: Preliminary experience. Dysphagia 1988;3:11–17.

    Article  PubMed  CAS  Google Scholar 

  35. Daly DD, Code CF, Anderson HA: Disturbances of swallowing and esophageal motility in patients with multiple sclerosis. Neurology 1962;59:250–256.

    Article  Google Scholar 

  36. Lieberman AN, Horowitz L, Redmond P, Pachter L, Lieberman I, Leibowitz M: Dysphagia in Parkinson’s disease. Am J Gastroenterol 1980;74:157–160.

    PubMed  CAS  Google Scholar 

  37. Leopold NA, Kagel MC: Dysphagia in Huntington’s disease. Neurology 1985;42:57–60.

    CAS  Google Scholar 

  38. Dalakas MC, Elder G, Hallett M, Ravits J, Baker M, Papadopoulos N, Albrecht P, Sever J: A longterm follow-up study of patients with post-poliomyelitis neuromuscular symptoms. N Engl J Med 1986;314:959–963.

    Article  PubMed  CAS  Google Scholar 

  39. Cashman NR, Maselli R, Wollmann RL, Roos R, Simon R, Antel JP: Late denervation in patients with antecedent paralytic poliomyelitis. N Engl J Med 1987;317:7–12.

    Article  PubMed  CAS  Google Scholar 

  40. McQuillen MP, Cantor HE, O’Rourke JR Jr: Myasthenic syndrome associated with antibiotics. Arch Neurol 1968;18:402–415.

    Article  PubMed  CAS  Google Scholar 

  41. Pittinger CB, Eryase Y, Adamson R: Antibiotic induced paralysis. Anesth Analg 1970;49:487.

    PubMed  CAS  Google Scholar 

  42. Swift TR: Disorders of neuromuscular transmission other than myasthenia gravis. Muscle Nerve 1981;4:334.

    Article  PubMed  CAS  Google Scholar 

  43. Adams RD, Victor M: Principles of Neurology, ed 4. New York, McGraw-Hill, 1989.

    Google Scholar 

  44. Murray JP: Deglutition in myasthenia gravis. Br J Radiol 1962;35:43–52.

    Article  PubMed  CAS  Google Scholar 

  45. Eaton LM, Lambert EH: Electromyography and electric stimulation of nerves and diseases of motor unit: Observations on myasthenia syndrome associated with malignant tumors. JAMA 1957;163:1117.

    Article  CAS  Google Scholar 

  46. Jacob H, Berkowitz D, McDonald E, Bernstein L, Beneventano T: The esophageal motility disorder of polymyositis: A prospective study. Arch Intern Med 1983;143:2262–2264.

    Article  PubMed  CAS  Google Scholar 

  47. Merieux P, Verity M, Clements P, Paulus H: Esophageal abnormalities and dysphagia in polymyositis and dermamyositis: Clinical, radiographic, and pathologic features. Arthritis Rheum 1983;26:961–968.

    Article  PubMed  Google Scholar 

  48. Hertzman PA, Blevins WL, Mayer J, Greenfield B, Ting M, Gleich GJ: Association of the eosinophilia-myalgia syndrome with the ingestion of tryptohan. N Engl J Med 1990;322:869–873.

    Article  PubMed  CAS  Google Scholar 

  49. Siegel Cl, Hendrix TR, Harvey JC: The swallowing disorder in myotonia dystrophica. Gastroenterology 1966;50:541–550.

    PubMed  CAS  Google Scholar 

  50. Duranceau A, Jamieson G, Clermont RJ: Oropharyngeal dysphagia in patients with oculopharyngeal muscular dystrophy. Can J Surg 1978;21:326–329.

    PubMed  CAS  Google Scholar 

Suggested Reading

  • Bartlett JG, Gorbach SL: The triple threat of aspiration pneumonia. Chest 1975;68:560–566.

    Article  PubMed  CAS  Google Scholar 

  • Braman SS, Davis SM: Wheezing in the elderly. Respiratory diseases. Geriatr Clin North Am 1986;2:269–283.

    CAS  Google Scholar 

  • Branchine JR, Brys DA, Schwarz RD, Enianya DT, Duran DO, Greenwald JE, Andresen BD: Clinical correlates of changes in receptors during aging, in Adelman RC, Roberts J, Baker GT III, Baskin SI, Cristofalo VJ (eds): Neural Regulatory Mechanisms during Aging. Modern Aging Series, Vol. I. New York, Alan R. Liss, Inc, 1980, pp 129–141.

    Google Scholar 

  • Elliott JL: Swallowing disorders in the elderly: A guide to diagnosis and treatment. Geriatrics 1988;43:95–100.

    PubMed  CAS  Google Scholar 

  • Margulies SI, Brunt PW, Donner MW, Silbiger ML: Familial dysautonomia: A cineradiographic study of the swallowing mechanism. Radiology 1968;90:107–112.

    PubMed  CAS  Google Scholar 

  • Patel GK, Diner WC, Texter EC Jr: Swallowing and pharyngoesophageal function in the aging patient, in Texter EC Jr (ed): The Aging Gut. Paris, Masson Publishers USA, Inc, 1983.

    Google Scholar 

  • Sheth N, Diner WC: Swallowing problems in the elderly. Dysphagia 1988;2:209–215.

    Article  PubMed  CAS  Google Scholar 

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© 1991 Springer Science+Business Media New York

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Donner, M.W., Jones, B. (1991). Aging and Neurological Disease. In: Jones, B., Donner, M.W. (eds) Normal and Abnormal Swallowing. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4150-6_12

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  • DOI: https://doi.org/10.1007/978-1-4757-4150-6_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4757-4152-0

  • Online ISBN: 978-1-4757-4150-6

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