Calcium Signaling in Microglial Cells
Receptor-mediated changes in the free cytoplasmic Ca2+ concentration ([Ca2+]c) represent one of the major signal transduction pathways by which information from extracellular signals is transferred to intracellular sites. The signal is conveyed by the magnitude, duration and location of the changes in [Ca2+]c, and is usually initiated by the binding of an extracellular signaling molecule / ligand to its plasma membrane receptor. This chapter will provide a brief overview of the basic mechanisms of Ca2+ signaling, describe the available data about microglial [Ca2+]c signals, and discuss current challenges and future directions of this emerging field.
KeywordsMicroglial Cell Calcium Signaling Internal Store Endoplasmic Reticu Human Microglia
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