Microglial Ion Channels
In all living cells, ion channels are required to regulate the membrane potential and intracellular ion concentrations. Functional ion channels allow movements of cations or anions across the membrane, which subsequently may influence a variety of cellular processes, such as proliferation, excitability, migration, apoptosis, secretion and others. Ion channels are specialized membrane proteins that span the plasma membrane. They form hydrophilic pores through which ions flow from one side of the membrane to the other down their electrochemical gradient.
KeywordsMicroglial Cell Regulatory Volume Decrease Proton Channel Flufenamic Acid Human Microglia
Unable to display preview. Download preview PDF.
- DeCoursey TE, Grinstein S (1999). Ion channels and carriers in leukocytes. In: Inflammation: Basic principles and clinical correlates. JI Gallin and R Snyderman, eds. Lippincott Williams & Wilkins, New York, pp. 639–659.Google Scholar
- Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG (1994). Pharmacological characterization of five cloned voltage-gated K+ channels, types Kvl.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol Pharmacol 45:1227–1234.PubMedGoogle Scholar
- Heinemann U, Eder C (1997). Control of neuronal excitability. In: Epilepsy: A comprehensive textbook. (Eds.: Engel J Jr., Pedley TA), pp. 237–250, Lippincott-Raven Publishers, Philadelphia.Google Scholar
- Heinemann U, Konnerth A, Pumain R, Wadman WJ (1986). Extracellular calcium and potassium concentration changes in chronic epileptic brain tissue. In: Advances in Neurology/Basic mechanism of the epilepsies (Eds.: Delgado-Escueta AV, Ward AA, Woodbury DM, Porter RJ), pp. 641–661, Raven Press, New York.Google Scholar
- Schilling T, Quandt FN, Cherny VV, Zhou W, Heinemann U, DeCoursey TE, Eder C (2000). Upregulation of Kvl.3 K+ channels in microglia deactivated by TGF-β. Am J Physiol (Cell Physiol) 279:C1123–C1134.Google Scholar