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Microglia in the Regenerating and Degenerating Central Nervous System pp 275–305Cite as

Microglia and Aging in the Brain

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Abstract

Microglial activation during normal aging in the CNS is puzzling. In general, microglial activation is associated with neuron death, blood-brain barrier disruption, or invading lymphocytes, whereas, as we shall discuss, there is little evidence for such changes during normal aging. Microglial age changes may also interact with Alzheimer’s disease, which increases markedly during aging, as well as with inflammatory processes of aging in peripheral tissues.

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Authors
  1. Caleb E. Finch
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  2. Todd E. Morgan
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  3. Irina Rozovsky
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  4. Zhong Xie
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  5. Richard Weindruch
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  6. Tomas Prolla
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Editors and Affiliations

  1. Department of Neuroscience, University of Florida College of Medicine, 100 Newell Drive, 32611, Gainesville, FL, USA

    Wolfgang J. Streit

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Finch, C.E., Morgan, T.E., Rozovsky, I., Xie, Z., Weindruch, R., Prolla, T. (2002). Microglia and Aging in the Brain. In: Streit, W.J. (eds) Microglia in the Regenerating and Degenerating Central Nervous System. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-4139-1_13

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  • DOI: https://doi.org/10.1007/978-1-4757-4139-1_13

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